Personal profile

Research interests

Transcription Factors in Human Disease

Role of Runx2 in bone metastasis. Breast and prostate cancers preferentially spread to bone. Bone metastases cause extreme bone pain, fractures, nerve compression, and hypercalcaemia; the average survival time for patients is approximately two years. The development of therapies to combat bone metastasis largely depends on identifying new molecular targets for pharmacological intervention. What causes breast and prostate cancer cells to preferentially colonise the bone is largely unknown. However, work in my laboratory on the transcription factor Runx2 has revealed a fundamental molecular link between breast and bone-specific gene expression (Inman and Shore, 2003; Inman et al, 2005, Shore, 2005). Evidence is now accumulating that Runx2 controls metastatic cell invasion and contributes to tumour growth and osteolytic disease. Our ongoing research is focussed on identifying Runx2-regulated genes in metastatic cancer cells that contribute to invasion and early colonization phases of the bone microenvironment.

Regulation of Runx2 function

The transcription factor Runx2 is essential for development of the skeleton whereas Oct-1 is a ubiquitous transcription factor involved in the regulation of numerous genes. We have recently identified a novel complex formed between these two important transcription factors (Inman et al, 2005). We are using a “ChIP on chip” approach to identify Runx2/Oct-1 target genes. We have also shown that Oct-1 counteracts auto-inhibition of Runx2 DNA-binding to stimulate the formation of the Runx2/Oct-1 complex. Auto-inhibition of DNA-binding is a potent mechanism to repress the activity of a transcription factor and mechanisms to counteract it are often central to the regulation of transcription factor function. We therefore aim to elucidate the molecular mechanism of Runx2 auto-inhibition and establish the extent to which other Runx2-interacting partners modulate auto-inhibition.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Doctor of Philosophy

Award Date: 30 Jun 1993

External positions

External Examiner for UG Programmes in Cancer, Cell and Microbiolgy, University of Bristol

30 Sept 201630 Jun 2020

Associate Editor, Journal of Cellular Physiology

30 Jul 2011 → …

Editorial Advisory Board member , FEBS Journal

30 Sept 2002 → …


Dive into the research topics where Paul Shore is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or