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Philip Crosbie, MBChB, FRCP (Edin), PhD


Personal profile


Phil is a Professor of Respiratory Medicine and Honorary Consultant based in the Division of Infection, Immunity and Respiratory Medicine at the Univesity of Manchester and at Wythenshawe Hospital, Manchester University NHS Foundation Trust. His research and clinical focus is the early detection of lung cancer.

Research interests

Lung cancer is the leading cause of cancer mortality in the world and the leading cause of premature death in Manchester. Early detection of lung cancer is critically important to improve survival. My research interests include

1. Early detection of lung cancer: including targeted, community-based, low dose CT screening.

2. The study of lung cancer biomarkers to further understand the biology of early stage disease and develop novel approaches for early detection.

 Current studies include:

1. Yorkshire Lung Screening Trial (YLST) (co-chief investigator); funded by Yorkshire Cancer Research (2017-23).

2. YLST Biomarker Sub-Study (chief investigator); funded by Yorkshire Cancer Research (2018-22).

3. The Community Lung Health Study (PI); funded by Cancer Research UK (2017-18).

4. Manchester Early Detection of Lung Disease Pilot (Research lead / database PI); funded by Macmillan Cancer Support and developed in collaboration with the Macmillan Cancer Improvement Partnership (2016-18).

5. Lung Cancer Indicator Detection: LuCID (local PI). Cambridge University and Owlstone.

6. SPUtNIk: Accuracy and cost effectiveness of dynamic contrast enhanced computed tomography in the characterisation of solitary pulmonary nodules. (local PI); University of Southampton.

7. Tumourigenicity of circulating tumour cells in early stage lung cancer to predict disease recurrence (PI), with Prof Dive, CRUK Manchester Institute (2015-19).

8. TRACERx: TRAcking lung Cancer Evolution through treatment (Rx). (2013-22) (Co-investigator; UCL).

My collaborations

Prof Caroline Dive - Clinical and Experimental Pharmacology Group, CRUK Manchester Institute

Prof Tony Whetton - Stem Cell and Leukaemia Proteomics Laboratory, University of Manchester



Memberships of committees and professional bodies

Member of the Royal College of Physicians (Edinburgh)

British Thoracic Society

Methodological knowledge

Clinical study design and set up (attended ECCO-AACR-EORTC-ESMO Workshop, Jun 2011: "Methods in Clinical Cancer Research" Flims, Switzerland).

Statistical analysis.

Good Clinical Practice trained.

Lung cancer screening.


  • MBChB (Edinburgh University Medical School) 1997
  • PhD (University of Manchester) 2007
  • CCT Respiratory and General Internal Medicine, Oct 2011
  • FRCP (Edinburgh)

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

External positions

Visiting Senior Lecturer, University of Leeds

Mar 2018Mar 2023

Early Detection Theme Lead, CRUK Lung Cancer Centre of Excellence


Lung CSG member, National Cancer Research Institute (NCRI)


Research Beacons, Institutes and Platforms

  • Lydia Becker Institute


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