Research output per year
Research output per year
- 1 - 50 out of 58 results
Search results
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2025
Associations between work characteristics and osteoarthritis: A cross-sectional study of 285,947 UK Biobank participants
Hashmi, A., Scott, S., Jung, M., Meng, Q.-J., Tobias, J. H., Beynon, R. A. & Faber, B. G., Mar 2025, In: Osteoarthritis and Cartilage Open. 7, 1, 100565.Research output: Contribution to journal › Article › peer-review
Open Access -
A synthetic chronogenetic gene circuit for programmed circadian drug delivery
Pferdehirt, L., Damato, A. R., Lenz, K. L., Gonzalez-Aponte, M. F., Palmer, D., Meng, Q.-J., Herzog, E. D. & Guilak, F., 7 Feb 2025, In: Nature Communications. 16, 1457 .Research output: Contribution to journal › Article › peer-review
Open Access -
Can we utilise the circadian clock to target cancer stem cells?
Lian, J.-W., Li, S.-Y., Clarke, R. B., Howell, S. J. & Meng, Q.-J., 28 Feb 2025, In: Cancer Letters. 611, 217360.Research output: Contribution to journal › Article › peer-review
Open Access -
Quantitative measures of clock protein dynamics in the mouse suprachiasmatic nucleus extends the circadian time-keeping model
Smyllie, N. J., Koch, A. A., Adamson, A. D., Patton, A. P., Johnson, A., Bagnall, J. S., Johnson, O., Meng, Q.-J., Loudon, A. S. I. & Hastings, M. H., 17 Apr 2025, In: The EMBO Journal.Research output: Contribution to journal › Article › peer-review
Open Access -
The glomerular circadian clock temporally regulates basement membrane dynamics and the podocyte glucocorticoid response
Preston, R., Chrisp, R., Dudek, M., Paiva Teixeira Morais, M., Tian, P., Williams, E., Naylor, R., Davenport, B., Pathiranage, D., Benson, E., Spiller, D., Bagnall, J., Zeef, L., Lawless, C., Baker, S. M., Meng, Q.-J. & Lennon, R., Jan 2025, In: Kidney International. 107, 1, p. 99-115Research output: Contribution to journal › Article › peer-review
Open Access -
2024
Meteorin-like protein/METRNL/Interleukin-41 ameliorates atopic dermatitis-like inflammation
Huang, D., Liu, X., Gao, X., Choi, C. K., Giglio, G., Farah, L., Leung, T.-F., Wong, K.C.-Y., Kan, L.L.-Y., Chong, J.W.-H., Meng, Q.-J., Liao, J., Cheung, P.F.-Y. & Wong, C.-K., 10 May 2024, (E-pub ahead of print) In: Allergy.Research output: Contribution to journal › Article › peer-review
Open Access -
Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in luminal A breast cancer
Li, S.-Y., Hammarlund, J. A., Wu, G., Lian, J.-W., Howell, S. J., Clarke, R. B., Adamson, A. D., Gonçalves, C. F., Hogenesch, J. B., Anafi, R. C. & Meng, Q.-J., 6 Feb 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 7, p. e2311854121Research output: Contribution to journal › Article › peer-review
Open AccessFile55 Downloads (Pure) -
2023
Circadian Disruption Primes Myofibroblasts for Accelerated Activation as a Mechanism Underpinning Fibrotic Progression in Non-Alcoholic Fatty Liver Disease
Jokl, E., Llewellyn, J., Simpson, K., Adegboye, O., Pritchett, J., Zeef, L., Donaldson, I., Athwal, V., Purssell, H., Street, O., Bennett, L., Guha, I. N., Hanley, N. A., Meng, Q.-J. & Hanley, K. P., 8 Jun 2023, In: Cells. 12, 12, 1582.Research output: Contribution to journal › Article › peer-review
Open Access -
Directed differentiation of hPSCs through a simplified lateral plate mesoderm protocol for generation of articular cartilage progenitors
Smith, C. A., Humphreys, P. A., Naven, M. A., Woods, S., Mancini, F. E., O'Flaherty, J., Meng, Q.-J. & Kimber, S. J., 27 Jan 2023, In: PLoS ONE. 18, 1, e0280024.Research output: Contribution to journal › Article › peer-review
Open Access -
Macromolecular condensation buffers intracellular water potential
Watson, J. L., Seinkmane, E., Styles, C. T., Mihut, A., Krüger, L. K., McNally, K. E., Planelles-Herrero, V. J., Dudek, M., McCall, P. M., Barbiero, S., Vanden Oever, M., Peak-Chew, S. Y., Porebski, B. T., Zeng, A., Rzechorzek, N. M., Wong, D. C. S., Beale, A. D., Stangherlin, A., Riggi, M. & Iwasa, J. & 11 others, , 23 Nov 2023, In: Nature . 623, 7988, p. 842-852 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mechanical loading and hyperosmolarity as a daily resetting cue for skeletal circadian clocks
Dudek, M., Pathiranage, D., Bano Otalora, B., Paszek, A., Rogers, N., Gonçalves, C. F., Lawless, C., Wang, D., Luo, Z., Yang, L., Guilak, F., Hoyland, J. & Meng, Q.-J., 14 Nov 2023, In: Nature Communications. 14, 1, 7237.Research output: Contribution to journal › Article › peer-review
Open Access -
Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts
Yeung, C.-Y. C., Garva, R., Pickard, A., Lu, Y., Mallikarjun, V., Swift, J., Taylor, S. H., Rai, J., Eyre, D. R., Chaturvedi, M., Itoh, Y., Meng, Q.-J., Mauch, C., Zigrino, P. & Kadler, K. E., 1 Dec 2023, In: Matrix biology : journal of the International Society for Matrix Biology. 124, p. 8-22 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The circadian clock and extracellular matrix homeostasis in ageing and age-related diseases
Dudek, M., Swift, J. & Meng, Q.-J., 29 May 2023, (E-pub ahead of print) In: American Journal of Physiology-Cell Physiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile268 Downloads (Pure) -
The clock transcription factor BMAL1 is a key regulator of extracellular matrix homeostasis and cell fate in the intervertebral disc
Dudek, M., Morris, H., Rogers, N., Pathiranage, D. R., Raj, S. S., Chan, D., Kadler, K. E., Hoyland, J. & Meng, Q.-J., 1 Sept 2023, In: Matrix biology : journal of the International Society for Matrix Biology. 122, p. 1-9 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Development of human cartilage circadian rhythm in a stem cell-chondrogenesis model
Naven, M., Zeef, L., Li, S., Humphreys, P., Smith, C., Pathiranage, D., Cain, S., Woods, S., Bates, N., Au, M., Wen, C., Kimber, S. & Meng, Q.-J., 1 Jul 2022, In: Theranostics. 12, 8, p. 3963-3976 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock
Koch, A. A., Bagnall, J. S., Smyllie, N. J., Begley, N., Adamson, A. D., Fribourgh, J. L., Spiller, D. G., Meng, Q.-J., Partch, C. L., Strimmer, K., House, T. A., Hastings, M. H. & Loudon Andrew S., I., 14 Mar 2022, In: eLife. 11, 30 p., e73976.Research output: Contribution to journal › Article › peer-review
Open Access -
Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration
Wang, D., Peng, P., Dudek, M., Hu, X., Xu, X., Shang, Q., Wang, D., Jia, H., Wang, H., Gao, B., Zheng, C., Mao, J., Gao, C., He, X., Cheng, P., Wang, H., Zheng, J., Hoyland, J., Meng, Q.-J. & Luo, Z. & 1 others, , 25 Feb 2022, In: Bone Research. 10, 1, 20.Research output: Contribution to journal › Article › peer-review
Open Access -
Synthetic gene circuits for preventing disruption of the circadian clock due to interleukin-1–induced inflammation
Pferdehirt, L., Damato, A. R., Dudek, M., Meng, Q.-J., Herzog, E. D. & Guilak, F., 27 May 2022, In: Science Advances.Research output: Contribution to journal › Article › peer-review
Open Access -
The dynamic kidney matrisome - is the circadian clock in control?
Preston, R., Meng, Q.-J. & Lennon, R., 12 May 2022, In: Matrix Biology. 114, p. 138-155 18 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Circadian time series proteomics reveals daily dynamics in cartilage physiology
Dudek, M., Angelucci, C., Ruckshanthi, J. P. D., Wang, P., Mallikarjun, V., Lawless, C., Swift, J., Kadler, K., Hoyland, J., Lamandé, S. R., Bateman, J. & Meng, Q.-J., 29 Apr 2021, In: Osteoarthritis and Cartilage.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Circadian control of the secretory pathway maintains collagen homeostasis
Chang, J., Garva, R., Pickard, A., Yeung, C.-Y. C., Mallikarjun, V., Swift, J., Holmes, D. F., Calverley, B., Lu, Y., Adamson, A., Raymond-Hayling, H., Jensen, O., Shearer, T., Meng, Q. J. & Kadler, K. E., 6 Jan 2020, In: Nature Cell Biology. 22, 1, p. 74-86 13 p.Research output: Contribution to journal › Article › peer-review
File532 Downloads (Pure) -
Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator
Yang, N., Smyllie, N. J., Morris, H., Gonçalves, C. F., Dudek, M., Pathiranage, D. R. J., Chesham, J. E., Adamson, A., Spiller, D. G., Zindy, E., Bagnall, J., Humphreys, N., Hoyland, J., Loudon, A. S. I., Hastings, M. H., Meng, Q.-J. & Kramer, A. (Editor), 30 Apr 2020, In: PLoS Genetics. 16, 4, p. e1008729Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Influence of the extracellular matrix on cell-intrinsic circadian clocks
Streuli, C. H. & Meng, Q.-J., 1 Feb 2019, In: Journal of Cell Science.Research output: Contribution to journal › Article › peer-review
Open Access -
Knockdown of cytokeratin 8 overcomes chemoresistance of chordoma cells by aggravating endoplasmic reticulum stress through PERK/eIF2α arm of unfolded protein response and blocking autophagy
Wang, D., Zhang, P., Xu, X., Wang, J., Wang, D., Peng, P., Zheng, C., Meng, Q.-J., Yang, L. & Luo, Z., 25 Nov 2019, In: Cell Death and Disease. 10, 887.Research output: Contribution to journal › Article › peer-review
Open Access -
Preservation of circadian rhythms by the protein folding chaperone, BiP
Pickard, A., Chang, J., Alachkar, N., Calverley, B., Garva, R., Arvan, P., Meng, Q.-J. & Kadler, K., 30 May 2019, In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology.Research output: Contribution to journal › Article › peer-review
Open Access -
2018
Disrupted circadian clocks and altered tissue mechanics in primary human breast tumours
Broadberry, E., Mcconnell, J., Williams, J., Yang, N., Zindy, E., Leek, A., Waddington, R., Joseph, L., Howe, M., Meng, Q.-J. & Streuli, C. H., 2018, In: Breast Cancer Research. 20, 1Research output: Contribution to journal › Article › peer-review
Open Access -
Epithelial and stromal circadian clocks are inversely regulated by their mechanomatrix environment
Williams, J., Yang, N., Wood, A., Zindy, E., Meng, Q.-J. & Streuli, C., 6 Mar 2018, In: Journal of Cell Science.Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Cellular mechano-environment regulates the mammary circadian clock
Yang, N., Williams, J., Pekovic-Vaughan, V., Wang, P., Olabi, S., McConnell, J., Gossan, N., Hughes, A., Cheung, J., Streuli, C. H. & Meng, Q.-J., 30 Jan 2017, In: Nature Communications. 8, p. 14287Research output: Contribution to journal › Article › peer-review
Open Access -
Involvement of posttranscriptional regulation of Clock in the emergence of circadian clock oscillation during mouse development
Umemura, Y., Koike, N., Ohashi, M., Tsuchiya, Y., Meng, Q. J., Minami, Y., Hara, M., Hisatomi, M. & Yagita, K., 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 36, p. E7479-E7488Research output: Contribution to journal › Article › peer-review
Open Access -
The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration
Dudek, M., Yang, N., Ruckshanthi, J. P. D., Williams, J., Borysiewicz, E., Wang, P., Adamson, A., Li, J., Bateman, J. F., White, M., Boot-Handford, R., Hoyland, J. & Meng, Q.-J., Mar 2017, In: Annals of the rheumatic diseases. 76, 3, p. 576-584Research output: Contribution to journal › Article › peer-review
Open AccessFile423 Downloads (Pure) -
2016
Circadian clocks and breast cancer
Blakeman, V., Williams, J., Meng, Q.-J. & Streuli, C. H., 2016, In: Breast Cancer Research. 18, 1, 9 p., 89.Research output: Contribution to journal › Article › peer-review
Open Access -
Circadian Clocks in Articular Cartilage and Bone: A Compass in the Sea of Matrices
Yang, N. & Meng, Q.-J., Oct 2016, In: Journal of Biological Rhythms. 31, 5, p. 415-427 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile144 Downloads (Pure) -
The brain-joint axis in osteoarthritis: nerves, circadian clocks and beyond
Berenbaum, F. & Meng, Q.-J., Sept 2016, In: Nature Reviews. Rheumatology. 12, 9, p. 508-516 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile183 Downloads (Pure) -
The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity.
Dudek, M., Gossan, N., Yang, N., Im, H.-J., Ruckshanthi, J. P. D., Yoshitane, H., Li, X., Jin, D., Wang, P., Boudiffa, M., Bellantuono, I., Fukada, Y., Boot-Handford, R. & Meng, Q.-J., 4 Jan 2016, In: Journal of Clinical Investigation. 126, 1, p. 365-376 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Visualizing and Quantifying Intracellular Behavior and Abundance of the Core Circadian Clock Protein PERIOD2
Smyllie, N. J., Pilorz, V., Boyd, J., Meng, Q.-J., Saer, B., Chesham, J. E., Maywood, E. S., Krogager, T. P., Spiller, D., Boot-Handford, R., White, M., Hastings, M. H. & Loudon, A., 25 Jul 2016, In: Current Biology. 26, 14, p. 1880-1886 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2015
Ageing and osteoarthritis: a circadian rhythm connection.
Gossan, N., Boot-Handford, R. & Meng, Q.-J., Apr 2015, In: Biogerontology. 16, 2Research output: Contribution to journal › Article › peer-review
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Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway.
Guo, B., Yang, N., Borysiewicz, E., Dudek, M., Williams, J. L., Li, J., Maywood, E. S., Adamson, A., Hastings, M. H., Bateman, J. F., White, M. R. H., Boot-Handford, R. P. & Meng, Q. J., Nov 2015, In: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 23, 11Research output: Contribution to journal › Article › peer-review
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Environmental disruption of circadian rhythm predisposes mice to osteoarthritis-like changes in knee joint.
Kc, R., Li, X., Voigt, R. M., Ellman, M. B., Summa, K. C., Vitaterna, M. H., Keshavarizian, A., Turek, F. W., Meng, Q.-J., Stein, G. S., van Wijnen, A. J., Chen, D., Forsyth, C. B. & Im, H.-J., Sept 2015, In: Journal of Cellular Physiology. 230, 9Research output: Contribution to journal › Article › peer-review
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Osteoarthritis-like pathologic changes in the knee joint induced by environmental disruption of circadian rhythms is potentiated by a high-fat diet.
Kc, R., Li, X., Forsyth, C. B., Voigt, R. M., Summa, K. C., Vitaterna, M. H., Tryniszewska, B., Keshavarzian, A., Turek, F. W., Meng, Q.-J. & Im, H.-J., 2015, In: Scientific Reports. 5Research output: Contribution to journal › Article › peer-review
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The circadian clock in murine chondrocytes regulates genes controlling key aspects of cartilage homeostasis
Gossan, N., Zeef, L., Hensman, J., Hughes, A., Bateman, J. F., Rowley, L., Little, C. B., Piggins, H. D., Rattray, M., Boot-Handford, R. P. & Meng, Q. J., 2015, In: Arthritis & Rheumatism. 65, 9, p. 2334-2345 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2014
Circadian control of tissue homeostasis and adult stem cells.
Janich, P., Meng, Q.-J. & Benitah, S. A., Dec 2014, In: Current opinion in cell biology. 31Research output: Contribution to journal › Article › peer-review
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Gremlin-2 is a BMP antagonist that is regulated by the circadian clock
Yeung, C.-Y. C., Gossan, N., Lu, Y., Hughes, A., Hensman, J. J., Bayer, M. L., Kjær, M., Kadler, K. & Meng, Q.-J., 2014, In: Scientific Reports. 4, 5183 .Research output: Contribution to journal › Article › peer-review
Open AccessFile73 Downloads (Pure) -
Running on time: the role of circadian clocks in the musculoskeletal system
Dudek, M. & Meng, Q.-J., 1 Oct 2014, In: Biochemical Journal. 463, 1, p. 1-8 8 p.Research output: Contribution to journal › Article › peer-review
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The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis
Pekovic-Vaughan, V., Gibbs, J., Yoshitane, H., Yang, N., Pathiranage, D., Guo, B., Sagami, A., Taguchi, K., Bechtold, D., Loudon, A., Yamamoto, M., Chan, J., van, D. H. G., Fukada, Y. & Meng, Q.-J., 15 Mar 2014, In: Genes & development. 28, 6, p. 548-560 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor
Gossan, N. C., Zhang, F., Guo, B., Jin, D., Yoshitane, H., Yao, A., Glossop, N., Zhang, Y. Q., Fukada, Y. & Meng, Q. J., May 2014, In: Nucleic acids research. 42, 9, p. 5765-5775 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2013
A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin
Liu, W., Zi, M., Tsui, H., Chowdhury, S. K., Zeef, L., Meng, Q. J., Travis, M., Prehar, S., Berry, A., Hanley, N. A., Neyses, L., Xiao, R. P., Oceandy, D., Ke, Y., Solaro, R. J., Cartwright, E. J., Lei, M. & Wang, X., 10 Jun 2013, In: Circulation: Heart Failure. 6, 4, p. 833-844 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile77 Downloads (Pure) -
Shared Ageing Research Models (ShARM): a new facility to support ageing research
Duran, A. L., Potter, P., Wells, S., Kirkwood, T., von Zglinicki, T., McArdle, A., Scudamore, C., Meng, Q.-J., de Haan, G., Corcoran, A. & Bellantuono, I., Dec 2013, In: Biogerontology. 14, 6, p. 789-94 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2012
Lithium impacts on the amplitude and period of the molecular circadian clockwork
Li, J., Lu, W. Q., Beesley, S., Loudon, A. S. I. & Meng, Q. J., 12 Mar 2012, In: PLoS ONE. 7, 3, e33292.Research output: Contribution to journal › Article › peer-review
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2011
GPR50 interacts with TIP60 to modulate glucocorticoid receptor signalling
Li, J., Hand, L. E., Meng, Q. J., Loudon, A. S. I. & Bechtold, D. A., 2011, In: PLoS ONE. 6, 8, e23725.Research output: Contribution to journal › Article › peer-review
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Tuning the period of the mammalian circadian clock: Additive and independent effects of CK1εTau and Fbxl3Afh mutations on mouse circadian behavior and molecular pacemaking
Maywood, E. S., Chesham, J. E., Meng, Q. J., Nolan, P. M., Loudon, A. S. I. & Hastings, M. H., 26 Jan 2011, In: Journal of Neuroscience. 31, 4, p. 1539-1544 5 p.Research output: Contribution to journal › Article › peer-review