Rachel Lennon, BMedSci, BMBS, PhD, FRCPCH

Search results

• 2024

  Detection of Alport gene variants in children and young people with persistent haematuria

  Ng, N. S. L., Yamamura, T., Shenoy, M., Stuart, H. M. & Lennon, R., 1 Oct 2024, (E-pub ahead of print) In: Pediatric Nephrology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microhematuria 100%
  • Family History 37%
  • Genetic Screening 25%
  • Proteinuria 12%
  • Exome Sequencing 12%

• Lung basement membranes are compositionally and structurally altered following resolution of acute inflammation.

  Brand, O., Kirkham, S., Jagger, C., Ozols, M., Lennon, R., Hussell, T. & Eckersley, A., 19 Aug 2024, bioRxiv.

  Research output: Other contribution

  • Serositis 100%
  • Basement Membrane 100%
  • Acute Inflammation 100%
  • Laminin 42%
  • Mouse 28%
• 2023

  Lung extracellular matrix modulates KRT5⁺ basal cell activity in pulmonary fibrosis

  Hewitt, R. J., Puttur, F., Gaboriau, D. C. A., Fercoq, F., Fresquet, M., Traves, W. J., Yates, L. L., Walker, S. A., Molyneaux, P. L., Kemp, S. V., Nicholson, A. G., Rice, A., Roberts, E., Lennon, R., Carlin, L. M., Byrne, A. J., Maher, T. M. & Lloyd, C. M., 27 Sept 2023, In: Nature Communications. 14, 1, 6039.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Extracellular Matrix 100%
  • Cell Activity 100%
  • Basal Cell 100%
  • Idiopathic Pulmonary Fibrosis 100%
  • Pulmonary Fibrosis 100%

• Matrikines in kidney ageing and age-related disease

  Eckersley, A., Yamamura, T. & Lennon, R., 1 Nov 2023, In: Current Opinion in Nephrology & Hypertension. 32, 6, p. 551-558 8 p., 10.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Diseases 100%
  • Disease 100%
  • Nephropathy 50%
  • Kidney Disease 50%
  • Extracellular Matrix 25%

• Peptide location fingerprinting identifies structural alterations within basement membrane components in ageing kidney

  Eckersley, A. (Lead), Paiva Teixeira Morais, M., Ozols, M. & Lennon, R. (Corresponding), Aug 2023, In: Matrix Biology. 121, p. 167-178 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Basement Membrane 100%
  • Membrane Component 100%
  • Canstatin 50%
  • Laminin 33%
  • Alpha Oxidation 16%

• Protocol to characterize basement membranes during kidney development using mass spectrometry-based label-free quantitative proteomics

  Morais, M. R. P. T., Tian, P., O'cualain, R., Lawless, C. & Lennon, R., 15 Dec 2023, In: STAR protocols. 4, 4, 102741.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mass Spectrometry 100%
  • Quantitative Proteomics 100%
  • Basement Membrane 100%
  • Kidney Development 100%
  • Mouse 25%
• 2022

  A basement membrane discovery pipeline uncovers network complexity, new regulators, and human disease associations

  Genomics England Research Consortium, 20 May 2022, In: Science Advances. 8, 20, 19 p., eabn2265.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Basement Membrane 100%
  • ADAMTS 12%
  • Gene Network 12%
  • Zebra Fish 12%
  • Caenorhabditis Elegans 12%

• A novel nanoluciferase transgenic reporter measures proteinuria in zebrafish

  Naylor, R. W., Lemarie, E., Jackson-Crawford, A., Davenport, J. B., Mironov, A., Lowe, M. & Lennon, R., 1 Oct 2022, In: Kidney International. 102, 4, p. 815-827

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zebra Fish 100%
  • Transgenics 100%
  • Proteinuria 100%
  • Transgenic Zebrafish 33%
  • Nephropathy 25%

• Basement membrane defects in CD151-associated glomerular disease

  Naylor, R. W., Watson, E., Williamson, S., Preston, R., Davenport, J. B., Thornton, N., Lowe, M., Williams, M. & Lennon, R., 12 Mar 2022, In: Pediatric Nephrology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proteinuria 100%
  • Basement Membrane 100%
  • Glomerulopathy 100%
  • CD151 100%
  • Glomerulus Basement Membrane 60%

• ­­­Kidney organoids recapitulate human basement membrane assembly in health and disease

  Morais, M. R., Tian, P., Lawless, C., Murtuza-baker, S., Hopkinson, L., Woods, S., Mironov, A., Long, D. A., Gale, D. P., Zorn, T. M., Kimber, S. J., Zent, R. & Lennon, R., 25 Jan 2022, In: eLife. 11

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Diseases 100%
  • Organoid 100%
  • Basement Membrane 100%
  • Genetic Variability 12%
  • Human Development 12%

• Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch

  Fresquet, M., Lockhart, M., Rhoden, S., Jowitt, T., Briggs, D., Baldock, C., Brenchley, P. & Lennon, R., 2022, In: Proceedings of the National Academy of Sciences.

  Research output: Contribution to journal › Article › peer-review

  • Membranous Glomerulonephritis 100%
  • Epitope 100%
  • Autoantibodies 60%
  • Cell Surface 40%
  • Cryo-Electron Microscopy 20%

• The dynamic kidney matrisome - is the circadian clock in control?

  Preston, R., Meng, Q.-J. & Lennon, R., 12 May 2022, In: Matrix Biology. 114, p. 138-155 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Circadian Rhythm 100%
  • Extracellular Matrix 100%
  • Disease 100%
  • Kidney Disease 100%
  • Nephropathy 60%
• 2021

  A novel nanoluciferase transgenic reporter to measure proteinuria in zebrafish

  Naylor, R. W., Lemarie, E., Jackson-Crawford, A., Davenport, J. B., Mironov, A., Lowe, M. & Lennon, R., 19 Jul 2021, In: Kidney International. 102, 4

  Research output: Contribution to journal › Article › peer-review

  • Zebra Fish 100%
  • Transgenics 100%
  • Proteinuria 100%
  • Transgenic Zebrafish 33%
  • Nephropathy 25%

• Complexities of the glomerular basement membrane

  Naylor, R. W., Morais, M. R. P. T. & Lennon, R., 24 Feb 2021, In: Nature Reviews Nephrology. 17, 2, p. 112-127 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Glomerulus Basement Membrane 100%
  • Diseases 25%
  • Membrane Component 16%
  • Water-Electrolyte Imbalance 8%
  • Diabetes Mellitus 8%
  802 Downloads (Pure)

• Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease

  Pokhilko, A., Brezzo, G., Handunnetthi, L., Heilig, R., Lennon, R., Smith, C., Allan, S. M., Granata, A., Sinha, S., Wang, T., Markus, H. S., Naba, A., Fischer, R., Van Agtmael, T., Horsburgh, K. & Cader, M. Z., 17 Mar 2021, In: Journal of Cerebral Blood Flow and Metabolism.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proteomics 100%
  • Mouse 100%
  • Extracellular Matrix Proteins 100%
  • Scleroprotein 100%
  • Cerebrovascular Disease 100%

• Identification of an altered matrix signature in kidney ageing and disease

  Randles, M., Lausecker, F., Kong, Q., Suleiman, H., Reid, G., Kolatsi-Joannou, M., Davenport, B., Tian, P., Falcone, S., Potter, P., Agtmael, T. V., Norman, J. T., Long, D. A., Humphries, M. J., Miner, J. H. & Lennon, R., 22 Apr 2021, (Accepted/In press) In: Journal of the American Society of Nephrology.

  Research output: Contribution to journal › Article › peer-review

  • Diseases 100%
  • Nephropathy 100%
  • Basement Membrane 50%
  • Matrix Protein 50%
  • Mass Spectrum 25%

• Ongoing Exposure to Peritoneal Dialysis Fluid Alters Resident Peritoneal Macrophage Phenotype and Activation Propensity.

  Sutherland, T., Shaw, T., Lennon, R., Herrick, S. & Rückerl, D., 27 Jul 2021, In: Frontiers in Immunology. 12, 715209.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Macrophage 100%
  • Liquid 100%
  • Peritoneal Dialysis 100%
  • Hemodialysis 22%
  • Peritonitis 22%
  88 Downloads (Pure)
• 2020

  A point-of-care immunosensor based on quartz crystal microbalance with graphene biointerface for antibody assay

  Hampitak, P., Jowitt, T., Melendrez Armada, D., Fresquet, M., Hamilton, P., Iliut, M., Nie, K., Spencer, B., Lennon, R. & Vijayaraghavan, A., 2 Oct 2020, (Accepted/In press) In: ACS Sensors.

  Research output: Contribution to journal › Article › peer-review

  • Graphene 100%
  • Reduced Graphene Oxide 100%
  • Film 33%
  • Oxide Surface 33%
  • Sensitive Detection 33%

• Autoantigens PLA2R and THSD7A in membranous nephropathy share a common epitope motif in the N-terminal domain

  Fresquet, M., Rhoden, S., Jowitt, T., Mckenzie, E., Roberts, I., Lennon, R. & Brenchley, P., 2020, In: Journal of Autoimmunity. 106, p. 1-12 12 p., 102308.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Membranous Glomerulonephritis 100%
  • Epitope 100%
  • Amino Terminal Sequence 100%
  • Autoantigen 100%
  • B Cell 25%

• Basement membrane ligands initiate distinct signalling networks to direct cell shape

  Randles, M. J., Lausecker, F., Humphries, J. D., Byron, A., Clark, S. J., Miner, J. H., Zent, R., Humphries, M. J. & Lennon, R., 6 Mar 2020, In: Matrix Biology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Basement Membrane 100%
  • Cell Shape 100%
  • Type IV Collagen 50%
  • Proteomics 50%
  • Laminin 50%

• Bilateral native nephrectomies for severe hypertension in children with stage 5 chronic kidney disease leads to improved BP control following transplantation

  Pickles, C., Kaur, A., Wallace, D., Brix, C., Lennon, R., Plant, N. & Shenoy, M., 1 Dec 2020, In: Pediatric Nephrology. 35, 12, p. 2373-2376

  Research output: Contribution to journal › Article › peer-review

  • Kidney Transplantation 100%
  • Blood Pressure 100%
  • Pressure Control 100%
  • Chronic Kidney Disease 100%
  • Nephrectomy 100%

• Clinical trial recommendations for potential Alport syndrome therapies

  Weinstock, B. A., Feldman, D. L., Fornoni, A., Gross, O., Kashtan, C. E., Lagas, S., Lennon, R., Miner, J. H., Rheault, M. N., Simon, J. F., Bonebrake, L., Dunleavy, M., Kumnick, P., Lagas, S., Parziale, G., Reed, J., Weinstock, A., Gear, S., Binaso, K. & Manuel, R. & 38 others, Simon, J., Appel, G., Blank, M., Tang, W., Thompson, A., Torra, R., Lieberman, K., Licht, C., Dahan, K., Nozu, K., Kai, H., Ricardo, S., Pariser, A., Feldman, D., Cook, H., Chin, M., Goldsberry, A., Meyer, C., Melia, L. A., Komers, R., Markels, M., Mercer, A., Prunotto, M., Morgenstern, B., Hariri, A., Modur, V., Turner, N., Gross, O., Fornoni, A., Kashtan, C., Rheault, M., Baigent, C., Desacco, S., Perin, L., Barua, M., Nakanishi, K., Jarad, G. & Miner, J., 1 Jun 2020, In: Kidney International. 97, 6, p. 1109-1116 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Alport Syndrome 100%
  • Clinical Trial Design 100%
  • Biological Marker 20%
  • Clinician 20%

• Global proteomic analysis of insulin receptor interactors in glomerular podocytes

  Hosawi, S. B., Humphries, J. D., Coward, R. J., Knight, D., Humphries, M. J. & Lennon, R., 26 Aug 2020, In: Wellcome open research. 5, p. 202

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proteomics 100%
  • Podocyte 100%
  • Insulin Receptor 100%
  • Doublecortin 41%
  • Insulin Signaling 25%
• 2019

  A role for OCRL in glomerular function and disease

  Preston, R., Naylor, R., Stewart, G., Bierzynska, A., Saleem, M. A., Lowe, M. & Lennon, R., 2019, In: Pediatric Nephrology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Diseases 100%
  • Proteinuria 100%
  • Podocyte 100%
  • Kidney Tubule Function 100%
  • Genetic Variability 50%

• From podocyte biology to novel cures for glomerular disease

  Torban, E., Braun, F., Wanner, N., Takano, T., Goodyer, P. R., Lennon, R., Ronco, P., Cybulsky, A. V. & Huber, T. B., Oct 2019, In: Kidney International. 96, 4, p. 850-861 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Podocyte 100%
  • Glomerulopathy 100%
  • Injury 12%
  • Diseases 12%
  • Mediator 12%
  86 Downloads (Pure)

• The importance of clinician, patient and researcher collaborations in Alport syndrome

  Rheault, M. N., Savige, J., Randles, M. J., Weinstock, A., Stepney, M., Turner, A. N., Parziale, G., Gross, O., Flinter, F. A., Miner, J. H., Lagas, S., Gear, S. & Lennon, R., 1 May 2019, In: Pediatric Nephrology.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Alport Syndrome 100%
  • Clinician 100%
  • Awareness 20%
  • Genetic Disorder 20%
  • Sensorineural Hearing Loss 20%

• The myriad possibility of kidney organoids

  Tian, P. & Lennon, R., 2019, In: Current Opinion in Nephrology & Hypertension. p. 1

  Research output: Contribution to journal › Article › peer-review

  • Organoid 100%
  • Diseases 36%
  • Human Pluripotent Stem Cell 36%
  • Drug Screening 18%
  • Proteomics 18%
• 2018

  3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening

  Hale, L. J., Howden, S. E., Phipson, B., Lonsdale, A., Er, P. X., Ghobrial, I., Hosawi, S., Wilson, S., Lawlor, K. T., Khan, S., Oshlack, A., Quinlan, C., Lennon, R. & Little, M. H., 4 Dec 2018, In: Nature Communications. 9, 1, p. 5167 1 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Diseases 100%
  • Drug Screening 100%
  • Glomerulus 100%
  • Organoid 100%
  • Podocyte 100%

• Basement membrane defects in genetic kidney diseases

  Lennon, R. & Chew, C., 2018, In: Frontiers in pediatrics. 6, 16 p., 11.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glomerulus Basement Membrane 100%
  • Basement Membrane 100%
  • Nephropathy 100%
  • Glomerulopathy 44%
  • Diseases 22%

• Engineered basement membranes: from in vivo considerations to cell-based assays

  Perry, G., Xiao, W., Welsh, G. I., Perriman, A. W. & Lennon, R., 2018, In: Integrative Biology (United Kingdom). 10, 11, p. 680-695 16 p.

  Research output: Contribution to journal › Review article › peer-review

  • Basement Membrane 100%
  • In Vitro 33%
  • Drug Screening 16%
  • Adherent Cell 16%
  • Drug Induced Disease 16%

• Generation of functioning nephrons by implanting human pluripotent stem cell-derived kidney progenitors.

  Bantounas, I., Ranjzad, P., Faris Syafiq, T. M., Silajdzic, E., Forster, D., Asselin, M.-C., Lewis, P., Lennon, R., Plagge, A., Wang, Q., Woolf, A. S. & Kimber, S., 8 Feb 2018, In: Stem Cell Reports. 10, 3, p. 766-779 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Human Pluripotent Stem Cell 100%
  • Nephron 100%
  • Stem Cell 100%
  • In Vitro 50%
  • Nephropathy 50%
• 2017

  ACTB loss-of-function mutations result in a pleiotropic developmental disorder

  Cuvertino, S., Stuart, H., Chandler, K. E., Roberts, N., Armstrong, R., Bernardini, L., Bhaskar, S., Callewaert, B., Clayton-Smith, J., Hernando Davalillo, C., Deshpande, C., Devriendt, K., Digilio, M. C., Dixit, A., Edwards, M., Friedman, J. M., Gonzalez-Meneses, A., Joss, S., Kerr, B. & Lampe, A. K. & 21 others, Langlois, S., Lennon, R., Loget, P., Ma, D. Y. T., Ruth, M., Des Medt, M., O'Sullivan, J., Odent, S., Parker, M. J., Pebrel-Richard, C., Petit, F., Stark, Z., Stockler-Ipsiroglu, S., Tinschert, S., Vasudevan, P., Villa, O., White, S. M., Zahir, F. R., study, T. D., Woolf, A. S. & Banka, S., 7 Dec 2017, In: American Journal of Human Genetics. 101, 6, p. 1021-1033 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Actin 100%
  • Loss of Function Mutation 100%
  • Mental Retardation 75%
  • Fibroblast 75%
  • Cell Shape 50%

• An inducible mouse model of podocin-mutation-related nephrotic syndrome

  Tabatabaeifar, M., Wlodkowski, T., Simic, I., Denc, H., Mollet, G., Weber, S., Moyers, J. J., Brühl, B., Randles, M. J., Lennon, R., Antignac, C. & Schaefer, F., 19 Oct 2017, In: PLoS ONE. 12, 10, e0186574.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mouse Model 100%
  • Podocin 100%
  • Nephrotic Syndrome 100%
  • Disease 83%
  • Diseases 83%

• Genetic testing in steroid-resistant nephrotic syndrome: why, who, when and how?

  Preston, R., Stuart, H. & Lennon, R., 2017, In: Pediatric Nephrology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genetic Screening 100%
  • Congenital Nephrotic Syndrome 100%
  • Podocyte 66%
  • Immunosuppressive Therapy 33%
  • High Throughput Sequencing 33%

• Glucocorticoid therapy regulates podocyte motility by inhibition of Rac1

  Mccaffrey, J., Webb, N., Poolman, T., Fresquet, M., Moxey, C., Zeef, L., Donaldson, I., Ray, D. & Lennon, R., 2017, In: Scientific Reports. 7

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glucocorticoid 100%
  • Podocyte 100%
  • Glucocorticoid Receptor 33%
  • Immune System 16%
  • Signaling Mechanism 11%

• Integrating Cell Sheets for Organ-on-a-chip Applications

  Loewenhardt, W., Saunders, R., Lennon, R. & Derby, B., 2017, In: Procedia CIRP. 65, p. 127-130 4 p.

  Research output: Contribution to journal › Conference article › peer-review

  Open Access

  • Proximal Tubule 100%
  • Biochemical Reactor 100%

• PLA2R binds to the annexin A2-S100A10 complex in human podocytes

  Fresquet, M., Jowitt, T., Mckenzie, E., Ball, M., Randles, M., Lennon, R. & Brenchley, P., 2017, In: Scientific Reports.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mannose Receptor 100%

• Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor

  Lay, A. C., Hurcombe, J. A., Betin, V. M. S., Barrington, F., Rollason, R., Ni, L., Gillam, L., Pearson, G. M. E., Østergaard, M. V., Hamidi, H., Lennon, R., Welsh, G. I. & Coward, R. J. M., 1 Nov 2017, In: Diabetologia. 60, 11, p. 2299-2311 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Insulin Resistance 100%
  • Podocyte 100%
  • Long Term Exposure 100%
  • Insulin Receptor 100%
  • Mouse 100%

• Proteomic definitions of basement membrane composition in health and disease

  Randles, M. J., Humphries, M. J. & Lennon, R., Jan 2017, In: Matrix biology : journal of the International Society for Matrix Biology. 57-58, p. 12-28 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Proteomics 100%
  • Basement Membrane 100%
  • Proteome 50%
  • Extracellular Matrix Proteins 50%
  • Scleroprotein 50%
  807 Downloads (Pure)

• Recent Developments in the Detection and Management of Acute Kidney Injury

  Mccaffrey, J., Kumar Dhakal, A., Milford, D., Webb, N. & Lennon, R., 1 Jan 2017, In: Archives of Disease in Childhood. 102

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Kidney Injury 100%
  • Acute Kidney Failure 100%
  • Liquid 100%
  • Biological Marker 37%
  • Risk Stratification 12%

• Vinculin is required to maintain glomerular barrier integrity

  Lausecker, F., Tian, X., Inoue, K., Wang, Z., Pedigo, C. E., Hassan, H., Liu, C., Zimmer, M., Jinno, S., Huckle, A. L., Hamidi, H., Ross, R. S., Zent, R., Ballestrem, C., Lennon, R. & Ishibe, S., 2017, In: Kidney International.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Vinculin 100%
  • Podocyte 100%
  • Cell Junction 66%
  • Glomerular Filtration Barrier 33%
  • Injury 16%
• 2016

  Advances and unmet needs in genetic, basic and clinical science in Alport syndrome: report from the 2015 International Workshop on Alport Syndrome

  Gross, O., Kashtan, C., Rheault, M., Flinter, F., Savige, J., Miner, J., Torra, R., Ars, E., Deltas, C., Savva, I., Perin, L., Renieri, A., Ariani, F., Mari, F., Baigent, C., Judge, P., Knebelman, B., Heidet, L., Lagas, S. & Blatt, D. & 18 others, Ding, J., Zhang, Y., Gale, D., Prunotto, M., Xue, Y., Schachter, A., Morton, L., Blem, J., Huang, M., Liu, S., Vallee, S., Renault, D., Schifter, J., Skelding, J., Gear, S., Friede, T., Turner, A. N. & Lennon, R., 2016, In: Nephrology, Dialysis, Transplantation.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

  Open Access

  File

  • COL4A4 100%
  • COL4A5 100%
  • Alport Syndrome 100%
  • Genetic Disorder 20%
  • Renal Failure 20%
  135 Downloads (Pure)

• ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice.

  Jones, F. E., Bailey, M. A., Murray, L. S., Lu, Y., McNeilly, S., Schlötzer-Schrehardt, U., Lennon, R., Sado, Y., Brownstein, D. G., Mullins, J. J., Kadler, K. E. & Van Agtmael, T., Feb 2016, In: DMM Disease Models and Mechanisms. 9, 2, p. 165-76 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Basement Membrane 100%
  • Nephropathy 100%
  • Endoplasmic Reticulum Stress 100%
  • Hypotension 33%
  • Bowman Capsule 33%

• Glomerular cell crosstalk

  Lennon, R. & Hosawi, S., May 2016, In: Current Opinion in Nephrology & Hypertension. 25, 3, p. 187-93

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Signaling Peptide 100%
  • Growth Factor 100%
  • Cell Surface Receptor 100%
  • Glomerulus Filtration 100%
  • Target Cell 100%

• The effects of extensive glomerular filtration of thin graphene oxide sheets on kidney physiology

  Jasim, D., Murphy, S., Newman, L., Mironov, A., Prestat, E., McCaffrey, J., Ménard-Moyon, C., Rodrigues, A. F., Bianco, A., Haigh, S., Lennon, R. & Kostarelos, K., 27 Dec 2016, In: ACS Nano. 10, 12, p. 10753–10767

  Research output: Contribution to journal › Article › peer-review

  • Graphene Oxide 100%
  • Glomerular Filtration Barrier 100%
  • Glomerulus Filtration 100%
  • Kidney Function 100%
  • Podocyte 75%

• The non-immunosuppressive management of childhood nephrotic syndrome

  McCaffrey, J., Lennon, R. & Webb, N. J. A., Sept 2016, In: Pediatric Nephrology. 31, 9, p. 1383-1402 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nephrotic Syndrome 100%
  • Immunosuppressive Drug 100%
  • Immunosuppressive Agent 100%
  • Clinician 33%
  • Edema 33%

• Three-dimensional electron microscopy reveals the evolution of glomerular barrier injury

  Randles, M. J., Collinson, S., Starborg, T., Mironov, A., Krendel, M., Königshausen, E., Sellin, L., Roberts, I. S. D., Kadler, K. E., Miner, J. H. & Lennon, R., 11 Oct 2016, In: Scientific Reports. 6, p. 35068 35068.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Injury 100%
  • Basement Membrane 100%
  • Podocyte 100%
  • Electron Microscopy 100%
  • Glomerulopathy 100%
• 2015

  Applying Proteomics to Investigate Extracellular Matrix in Health and Disease.

  Lennon, R. & Randles, M., 7 Jul 2015, In: Current Topics in Membranes. 76, p. 171-96

  Research output: Contribution to journal › Article › peer-review

• Coinheritance of COL4A5 and MYO1E mutations accentuate severity of kidney disease.

  Lennon, R., Stuart, H. M., Bierzynska, A., Randles, M., Kerr, B., Hillman, K., Batra, G., Campbell, J., Storey, H., Flinter, F. A., Koziell, A., Welsh, G. I., Saleem, M. A., Webb, N. J. A. & Woolf, A., 5 Mar 2015, In: Pediatric Nephrology. 30, p. 1459-1465 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Nephropathy 100%
  • Podocyte 100%
  • COL4A5 100%
  • Diseases 66%
  • Alport Syndrome 66%

• Genetic background is a key determinant of glomerular extracellular matrix composition and organization.

  Randles, M., Woolf, A., Huang, J., Byron, A., Humphries, J. D., Price, K., Kolatsi-Joannou, M., Collinson, S., Denny, T., Knight, D., Mironov, A., Starborg, T., Korstanje, R., Humphries, M. J., Long, D. & Lennon, R., 26 Dec 2015, In: American Society of Nephrology. Journal. 26, 12, p. 3021-3034 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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