Rainer Breitling

2024

An adaptable in silico ensemble model of the arachidonic acid cascade

Uttley, M., Turner Horne, G., Tsigkinopoulou, A., Del Carratore, F., Hawari, A., Kiezel-Tsugunova, M., Kendall, A., Jones, J., Messenger, D., Kaur Bhogal, R., Breitling, R. & Nicolaou, A., 27 May 2024, (Accepted/In press) In: Molecular Omics. 20, 7

Research output: Contribution to journal › Article › peer-review

Open Access

Bioproduction of methylated phenylpropenes and isoeugenol in Escherichia coli

Chua, J., Hanko, E. K. R., Yiakoumetti, A., Stoney, R. S., Chromy, J., Valdehuesa, K. N. G., Hollywood, K. A., Yan, C., Takano, E. & Breitling, R., 1 Jun 2024, In: Metabolic Engineering Communications. 18, e00237.

Research output: Contribution to journal › Article › peer-review

Open Access

Synthetic Biology of Natural Products Engineering: Recent Advances Across the Discover−Design−Build−Test−Learn Cycle

Foldi, J., Connolly, J., Takano, E. & Breitling, R., 20 Aug 2024, (E-pub ahead of print) In: ACS Synthetic Biology. 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Carboxylic acid reductase-dependent biosynthesis of eugenol and related allylphenols

Hanko, E., Valdehuesa, K. N., Verhagen, K. J. A., Chromy, J., Stoney, R., Chua, J., Yan, C., Roubos, J. A., Schmitz, J. & Breitling, R., 18 Nov 2023, In: Microbial Cell Factories. 22, 238.

Research output: Contribution to journal › Article › peer-review

Open Access

Expanding flavone and flavonol production capabilities in Escherichia coli

Yiakoumetti, A., Hanko, E. K. R., Zou, Y., Chua, J., Chromy, J., Stoney, R. A., Valdehuesa, K. N. G., Connolly, J. A., Yan, C., Hollywood, K. A., Takano, E. & Breitling, R., 18 Oct 2023, In: Frontiers in Bioengineering and Biotechnology.

Research output: Contribution to journal › Article › peer-review

ipaPy2: Integrated Probabilistic Annotation (IPA) 2.0 – an improved Bayesian-based method for the annotation of LC-MS/MS untargeted metabolomics data.

Del Carratore, F., Eagles, W., Borka, J. & Breitling, R., 25 Jul 2023, In: Bioinformatics (Oxford, England). 39, 7, btad455.

Research output: Contribution to journal › Article › peer-review

Open Access

Microbial production of the plant flavanone hesperetin from caffeic acid

Hanko, E. K. R., Correia, J., Souza, C. S., Green, A., Chromy, J., Stoney, R., Yan, C., Takano, E., Lousa, D., Soares, C. M. & Breitling, R., 18 Nov 2023, In: BMC Research Notes. 16, 343.

Research output: Contribution to journal › Article › peer-review

Open Access

SelenzymeRF: updated enzyme suggestion software for unbalanced biochemical reactions

Stoney, R., Hanko, E. K. R., Carbonell, P. & Breitling, R., 23 Nov 2023, In: Computational and Structural Biotechnology Journal. 21, 5868-5876.

Research output: Contribution to journal › Article › peer-review

Open Access

TFBMiner: A user-friendly command line tool for the rapid mining of transcription factor-based biosensors

Hanko, E. K. R., Joosab Noor Mahomed, T. A., Stoney, R. A. & Breitling, R., 13 Apr 2023, In: ACS Synthetic Biology.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Biotechnological application of Streptomyces for the production of clinical drugs and other bioactive molecules

Carratore, F. D., Hanko, E. K., Breitling, R. & Takano, E., 1 Oct 2022, In: Current Opinion in Biotechnology. 77, 7 p., 102762.

Research output: Contribution to journal › Article › peer-review

Open Access

Epigyne or epigynum? Some philological notes

Breitling, R. & et al., 29 Mar 2022, In: Arthropoda Selecta. 31, 1, p. 129–131

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Open Access

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What, if anything, is Lycosa accentuata Latreille, 1817? – Review of a nomenclatural conundrum (Araneae: Lycosidae)

Breitling, R. & Bauer, T., 12 Apr 2022, In: Zoosystema.

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Open Access

File

98 Downloads (Pure)

2021

A completely resolved phylogenetic tree of British spiders (Arachnida: Araneae)

Breitling, R., 12 Oct 2021, In: Ecologica Montenegrina. 46, p. 1-51

Research output: Contribution to journal › Article › peer-review

Open Access

Blood, sweat and tears: extraterrestrial regolith biocomposites with in vivo binders

Roberts, A., Whittall, D., Breitling, R., Takano, E., Blaker, J., Hay, S. & Scrutton, N., 3 Sept 2021, (Accepted/In press) In: Materials Today Bio.

Research output: Contribution to journal › Article › peer-review

Harnessing Intercellular Signals to Engineer the Soil Microbiome

Connolly, J., Harcombe, W., Smanski, M. J., Kinkel, L. L., Takano, E. & Breitling, R., 23 Nov 2021, (Accepted/In press) In: Natural Product Reports.

Research output: Contribution to journal › Article › peer-review

Multi-omics study of Planobispora rosea, producer of the thiopeptide antibiotic GE2270A

Del Carratore, F., Iorio, M., Pérez-Bonilla, M., Schmidt, K., Pérez-Redondo, R., Sosio, M., Macdonald, S. J., Gyulev, I. S., Tsigkinopoulou, A., Thomas, G. H., Genilloud, O., Rodríguez-García, A., Donadio, S., Breitling, R. & Takano, E., 3 Jun 2021, (Accepted/In press) In: mSystems.

Research output: Contribution to journal › Article › peer-review

On the authorship and publication dates of Theraphosa and Theraphosidae (Araneae, Mygalomorphae): a clarification

Breitling, R., 13 Oct 2021, (Accepted/In press) In: Bionomina.

Research output: Contribution to journal › Article › peer-review

Synthetic biology approaches to actinomycete strain improvement

Breitling, R., Avbelj, M., Bilyk, O., Del Carratore, F., Filisetti, A., Hanko, E. K. R., Iorio, M., Redondo, R. P., Reyes, F., Rudden, M., Severi, E., Slemc, L., Schmidt, K., Whittall, D. R., Donadio, S., García, A. R., Genilloud, O., Kosec, G., De Lucrezia, D. & Petković, H. & 2 others, Thomas, G. & Takano, E., 31 May 2021, In: FEMS microbiology letters.

Research output: Contribution to journal › Article › peer-review

Open Access

The evolving art of creating genetic diversity: from directed evolution to synthetic biology

Currin, A., Parker, S., Robinson, C., Takano, E., Scrutton, N. & Breitling, R., 26 Apr 2021, (Accepted/In press) In: Biotechnology Advances.

Research output: Contribution to journal › Article › peer-review

2020

Bioengineering horizon scan 2020

Kemp, L., Adam, L., Boehm, C. R., Breitling, R., Casagrande, R., Dando, M., Djikeng, A., Evans, N. G., Hammond, R., Hills, K., Holt, L. A., Kuiken, T., Markotić, A., Millett, P., Napier, J., Nelson, C., Oheigeartaigh, S. S., Osbourn, A., Palmer, M. J. & Patron, N. J. & 16 others, Perello, E., Piyawattanametha, W., Restrepo-Schild, V., Rios-Rojas, C., Rhodes, C., Roessing, A., Scott, D. J., Simuntala, C., Shapira, P., Smith, R. D. J., Sundaram, L. S., Takano, E., Uttmark, G., Wintle, B. C., Zahra, N. B. & Sutherland, W. J., 29 May 2020, In: eLife. 9:e54489.

Research output: Contribution to journal › Article › peer-review

Open Access

Engineering Escherichia coli towards de novo production of gatekeeper (2S)-flavanones: naringenin, pinocembrin, eriodictyol and homoeriodictyol.

Dunstan, M., Robinson, C., Jervis, A., Yan, C., Carbonell, P., Hollywood, K., Currin, A., Swainston, N., Le Feuvre, R., Micklefield, J., Faulon, J.-L., Breitling, R., Turner, N., Takano, E. & Scrutton, N., 6 Aug 2020, In: Synthetic Biology . 5, 1, ysaa012.

Research output: Contribution to journal › Article › peer-review

Open Access

Multi-Omics Analysis of the Effect of cAMP on Actinorhodin Production in Streptomyces coelicolor

Nitta, K., Carratore, F. D., Breitling, R., Takano, E., Putri, S. P. & Fukusaki, E., 5 Nov 2020, (E-pub ahead of print) In: Frontiers in Bioengineering and Biotechnology. 8

Research output: Contribution to journal › Article › peer-review

Open Access

Non-covalent protein-based adhesives for transparent substrates – bovine serum albumin vs. recombinant spider silk

Roberts, A., Finnigan, W., Kelly, P., Faulkner, M., Breitling, R., Takano, E., Scrutton, N., Blaker, J. & Hay, S., 10 Jul 2020, In: Materials Today Bio. 7, p. 100068

Research output: Contribution to journal › Article › peer-review

Open Access

Rapid prototyping of microbial production strains for the biomanufacture of potential material monomers

Robinson, C., Carbonell, P., Jervis, A., Yan, C., Hollywood, K., Currin, A., Swainston, N., Speiss, R., Taylor, S., Mulherin, P., Parker, S., Rowe, W., Matthews, N., Malone, K., Le Feuvre, R., Shapira, P., Barran, P., Turner, N., Micklefield, J. & Breitling, R. & 2 others, Takano, E. & Scrutton, N., 1 Jul 2020, In: Metabolic Engineering.

Research output: Contribution to journal › Article › peer-review

Open Access

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South European spiders from the Duffey collection in the Manchester Museum (Arachnida: Araneae)

Breitling, R., 30 Mar 2020, In: Arachnology.

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Open Access

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The effect of terminal globular domains on the response of recombinant mini-spidroins to fiber spinning triggers

Finnigan, W., Roberts, A., Ligorio, C., Scrutton, N., Breitling, R., Blaker, J. & Takano, E., 30 Jun 2020, In: Scientific Reports. 10671.

Research output: Contribution to journal › Article › peer-review

Open Access

Unravelling the γ-butyrolactone network in Streptomyces coelicolor by computational ensemble modelling

Tsigkinopoulou, A., Takano, E. & Breitling, R., 1 Jul 2020, (Accepted/In press) In: PL o S Computational Biology.

Research output: Contribution to journal › Article › peer-review

2019

Open Access

Dynamics of the human skin mediator lipidome in response to dietary omega-3 fatty acid supplementation

Kendall, A., Pilkington, S., Murphy, S., Del Carratore, F., Sunarwidhi, A. L., Kiezel-Tsugunova, M., Urquhart, P., Watson, R., Breitling, R., Rhodes, L. & Nicolaou, A., 2019, In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Research output: Contribution to journal › Article › peer-review

Open Access

Dynamics of the human skin mediator lipidome in response to dietary ω-3 fatty acid supplementation

Kendall, A. C., Pilkington, S. M., Murphy, S. A., Del Carratore, F., Sunarwidhi, A. L., Kiezel-Tsugunova, M., Urquhart, P., Watson, R. E. B., Breitling, R., Rhodes, L. E. & Nicolaou, A., 13 Sept 2019, In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 11, p. 13014-13027 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Efficient learning in metabolic pathway designs through optimal assembling

Carbonell, P., Faulon, J.-L. & Breitling, R., 26 Dec 2019, In: IFAC-PapersOnLine. 52, 26, p. 7-12 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Euophrys petrensis C. L. Koch, 1837, is a genuine member of the genus Talavera (Araneae: Salticidae)

Breitling, R., 2 Sept 2019, In: Bonn Zoological Bulletin.

Research output: Contribution to journal › Article › peer-review

Open Access

Highly multiplexed, fast and accurate nanopore sequencing for verification of synthetic DNA constructs and sequence libraries

Currin, A., Swainston, N., Dunstan, M., Jervis, A., Mulherin, P., Robinson, C., Taylor, S., Carbonell, P., Hollywood, K., Yan, C., Takano, E., Scrutton, N. & Breitling, R., 29 Oct 2019, In: Synthetic Biology .

Research output: Contribution to journal › Article › peer-review

Open Access

Integrated Probabilistic Annotation (IPA): A Bayesian-based annotation method for metabolomic proﬁles integrating biochemical connections, isotope patterns and adduct relationships

Del Carratore, F., Schmidt, K., Vinaixa, M., Hollywood, K., Greenland-Bews, C., Takano, E., Rogers, S. & Breitling, R., 19 Oct 2019, In: Analytical Chemistry.

Research output: Contribution to journal › Article › peer-review

Open Access

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Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in Escherichia coli

Jervis, A. J., Carbonell, P., Vinaixa, M., Dunstan, M. S., Hollywood, K. A., Robinson, C. J., Rattray, N. J. W., Yan, C., Swainston, N., Currin, A., Sung, R., Toogood, H., Taylor, S., Faulon, J.-L., Breitling, R., Takano, E. & Scrutton, N. S., 18 Jan 2019, In: ACS Synthetic Biology. 8, 1, p. 127-136 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

SelProm: A Queryable and Predictive Expression Vector Selection Tool for Escherichia coli

Jervis, A. J., Carbonell, P., Taylor, S., Sung, R., Dunstan, M. S., Robinson, C. J., Breitling, R., Takano, E. & Scrutton, N. S., 2019, In: ACS Synthetic Biology.

Research output: Contribution to journal › Article › peer-review

Steatoda nobilis, a false widow on the rise: A synthesis of past and current distribution trends

Bauer, T., Feldmeier, S., Krehenwinkel, H., Wieczorrek, C., Reiser, N. & Breitling, R., 2019, In: NeoBiota.

Research output: Contribution to journal › Article › peer-review

Open Access

Synthetic biology for fibres, adhesives and active camouflage materials in protection and aerospace

Roberts, A., Finnigan, W., Wolde-Michael, E., Kelly, P., Blaker, J., Hay, S., Breitling, R., Takano, E. & Scrutton, N., 2019, In: MRS Communications.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals

Carbonell, P., Jervis, A., Robinson, C., Yan, C., Dunstan, M., Swainston, N., Vinaixa, M., Hollywood, K., Currin, A., Rattray, N., Taylor, S., Spiess, R., Sung, R., Williams, A. R., Fellows, D., Stanford, N., Mulherin, P., Le Feuvre, R., Barran, P. & Goodacre, R. & 9 others, Turner, N., Goble, C., Guoqiang Chen, G., Kell, D., Micklefield, J., Breitling, R., Takano, E., Faulon, J.-L. & Scrutton, N., 2018, In: Communications Biology. 1, 66.

Research output: Contribution to journal › Article › peer-review

Open Access