Research output per year
Research output per year
Personal profile
Overview
Rebecca Holley is a Programme Manager for the RAPID-RT NIHR-funded grant in the division of Cancer Sciences. RAPID-RT aims to show the practical use of routinely collected data to determine the impact of changes in standard of care practices on patient outcomes. She has been a project manager in the radiotherapy related research group since 2018, and has extensive experience of supporting grant applications, managing projects to ensure success and managing clinical studies from idea to close out.
Additionally Rebecca manages a novel paediactric gene therapy clinical trial in the School of Biological sciences for patients with mucopolysaccharidosis. This trial follows on from extensive pre-clinical work in the group of Professor Brian Bigger, where Rebecca previously worked as a research fellow.
Rebecca obtained her PhD in Cancer Sciences in 2007 and has previously worked at The University of Manchester in various groups with a keen interest in embryonic stem cells and control of their differentiation, glycoaminoglycans and the use of stem cell gene therapy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Beacons, Institutes and Platforms
- Manchester Cancer Research Centre
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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211 Systemic inflammation leads to neuronal loss and exacerbates behavioural deficits in a mouse model of MPS IIIA
Mandolfo, O., Parker, H., Aguado, È., Learmonth, Y. I., Liao, A., O'Leary, C., Ellison, S. M., Taylor, J., Wood, S. R., Holley, R., Boutin, H. & Bigger, B., Feb 2024, In: Molecular genetics and metabolism. 141, 2, 1 p.Research output: Contribution to journal › Meeting Abstract › peer-review
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Challenges and opportunities for Real World Evidence in Radiotherapy – A view from the UK: Proceedings of a national workshop
Craddock, M., Dempsey, C., Abdulwahid, D., Baldwin, J. P. C., Banfill, K., Carver, A., Chaturvedi, A., Cheeseman, S., Cowell, G. W., Daly, M., Dekker, A., Dubash, S. R., Duffield, S., Fornacon-Wood, I., Garcia, M. A. C., Goodley, P., Green, H., Holley, R., Ingram, S. & Jones, S. & 12 others, , 7 Oct 2024, (Accepted/In press) In: ESMO Real World Data and Digital Oncology.Research output: Contribution to journal › Article › peer-review
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Design and validation of a GMP stem cell manufacturing protocol for MPSII hematopoietic stem cell gene therapy
Ellison, S., Buckland, K., Learmonth, Y., Day, V., Kalra, S., Howe, L., Roman-Rodriguez, F. J., Bonafont, J., Booth, L., Holley, R., Smythe, J., Jones, S., Thrasher, A., Booth, C. & Bigger, B. W., 1 Jun 2024, In: Molecular Therapy - Methods & Clinical Development. 32, 2, 101271.Research output: Contribution to journal › Article › peer-review
Open Access -
Generation of a novel immunodeficient mouse model of Mucopolysaccharidosis type IIIA to test human stem cell-based therapies
Mandolfo, O., Parker, H., Usman, A., Learmonth, Y. I., Holley, R. J., MacDonald, A., McKay, T. & Bigger, B., 1 Sept 2024, In: Molecular genetics and metabolism. 143, 1-2, 108533.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
Systemic immune challenge exacerbates neurodegeneration in a model of neurological lysosomal disease
Mandolfo, O., Parker, H., Aguado, È., Ishikawa Learmonth, Y., Liao, A. Y., O'Leary, C., Ellison, S., Forte, G., Taylor, J., Wood, S., Searle, R., Holley, R. J., Boutin, H. & Bigger, B. W., 15 Jul 2024, In: EMBO Molecular Medicine. 16, 7, p. 1579-1602 24 p.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Data for: Peptide Gels of Fully-Defined Composition and Mechanics for Probing Cell-Cell and Cell-Matrix Interactions In Vitro
Ashworth, J. C. (Contributor), Thompson, J. L. (Contributor), James, J. R. (Contributor), Slater, C. E. (Contributor), Pijuan-Galitó, S. (Contributor), Lis-Slimak, K. (Contributor), Holley, R. J. (Contributor), Meade, K. A. (Contributor), Thompson, A. (Contributor), Arkill, K. P. (Contributor), Tassieri, M. (Contributor), Wright, A. J. (Contributor), Farnie, G. (Contributor) & Merry, C. L. R. (Creator), Mendeley Data, 18 Jul 2019
DOI: 10.17632/r77hhgf99k.1, https://data.mendeley.com/datasets/r77hhgf99k
Dataset