Richard Baines

2023

A targeted, low-throughput compound screen in a Drosophila model of neurofibromatosis type 1 identifies simvastatin and BMS-204352 as potential therapies for autism spectrum disorder (ASD).

Dyson, A., Ryan, M., Garg, S., Evans, D. G. & Baines, R., 13 Mar 2023, (Accepted/In press) In: eNeuro.

Research output: Contribution to journal › Article › peer-review

Balance of Activity during a Critical Period Tunes a Developing Network

Hunter, I., Coulson, B., Pettini, T., Davies, J. J., Parkin, J., Landgraf, M. & Baines, R., 15 Aug 2023, (Accepted/In press) In: eLife.

Research output: Contribution to journal › Article › peer-review

Essential elements of radical pair magnetosensitivity in Drosophila

Bradlaugh, A. A., Fedele, G., Munro, A. L., Hansen, C. N., Hares, J. M., Patel, S., Kyriacou, C. P., Jones, A. R., Rosato, E. & Baines, R. A., 2 Mar 2023, In: Nature . 615, p. 111-116 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

A targeted, low-throughput compound screen in aDrosophilamodel of neurofibromatosis type 1 identifies simvastatin and BMS-204352 as potential therapies for autism spectrum disorder (ASD)

Dyson, A., Ryan, M., Garg, S., Evans, D. G. & Baines, R. A., 13 Nov 2022

Research output: Other contribution › peer-review

ATP6V0C variants impair vacuolar V-ATPase causing a neurodevelopmental disorder often associated with epilepsy

Mattison, K. A., Tossing, G., Mulroe, F., Simmons, C., Butler, K. M., Schreiber, A., Alsadah, A., Neilson, D. E., Naess, K., Wedell, A., Wredenberg, A., Sorlin, A., McCann, E., Burghel, G. J., Menendez, B., Hoganson, G. E., Botto, L. D., Filloux, F. M., Aledo-Serrano, Á., Gil-Nagel, A., & 24 othersTatton-Brown, K., Verbeek, N. E., van Hirtum-Das, M., Breckpot, J., Hammer, T. B., Møller, R. S., Whitney, A., Douglas, A. G. L., Kharbanda, M., Brunetti-Pierri, N., Morleo, M., Nigro, V., May, H. J., Tao, J. X., Argili, E., Sherr, E. H., Dobyns, W. B., Consortium, G. E. R., Baines, R. A., Warwicker, J., Parker, J. A., Banka, S., Campeau, P. M. & Escayg, A., 8 Sept 2022, In: Brain : a journal of neurology. awac330.

Research output: Contribution to journal › Article › peer-review

Open Access

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Electrophysiological validation of monosynaptic connectivity between premotor interneurons and the aCC motoneuron in the Drosophila larval CNS

Giachello, C. N. G., Hunter, I., Pettini, T., Coulson, B., Knufer, A., Cachero, S., Winding, M., Zarin, A. A., Kohsaka, H., Ngan Fan, Y., Nose, A., Landgraf, M. & Baines, R., 2022, In: The Journal of Neuroscience.

Research output: Contribution to journal › Article › peer-review

Loss of NF1 causes tactile hypersensitivity and impaired synaptic transmission in a Drosophila model of autism spectrum disorder

Dyson, A., Garg, S., Evans, D. G. & Baines, R. A., 4 Mar 2022

Research output: Other contribution

Loss of NF1 in Drosophila larvae causes tactile hypersensitivity and impaired synaptic transmission at the neuromuscular junction.

Dyson, A., Ryan, M., Evans, D. G. & Baines, R. A., 22 Sept 2022, (Accepted/In press) In: The Journal of Neuroscience.

Research output: Contribution to journal › Article › peer-review

Targeting firing rate neuronal homeostasis can prevent seizures

Mulroe, F., Lin, W-H., Scott, C. M-G., Aourz, N., Fan, Y. N., Coutts, G., Parrish, R. R., Smolders, I., Trevelyan, A., Wykes, R., Allan, S., Freeman, S. & Baines, R., 1 Oct 2022, In: DMM Disease Models and Mechanisms. 15, 10

Research output: Contribution to journal › Article › peer-review

Open Access

Targeting neuronal homeostasis to prevent seizures

Mulroe, F., Lin, W-H., Scott, C. M-G., Aourz, N., Fan, Y. N., Coutts, G., Parrish, R. R., Smolders, I., Trevelyan, A., Wykes, R., Allan, S., Freeman, S. & Baines, R. A., 7 Mar 2022

Research output: Other contribution

2021

Characterisation of seizure induction methods in Drosophila

Mituzaite, J., Petersen, R., Claridge-Chang, A. & Baines, R., 10 Jun 2021, (Accepted/In press) In: eNeuro.

Research output: Contribution to journal › Article › peer-review

Exploiting the Fruitfly, Drosophila melanogaster, to Identify the Molecular Basis of Cryptochrome-Dependent Magnetosensitivity

Bradlaugh, A., Munro, A., Jones, A. R. & Baines, R., 25 Jan 2021, (Accepted/In press) In: Quantum Reports .

Research output: Contribution to journal › Article › peer-review

The Drosophila Larval Locomotor Circuit Provides a Model to Understand Neural Circuit Development and Function

Hunter, I., Coulson, B., Zarin, A. A. & Baines, R., 9 Jun 2021, (Accepted/In press) In: Frontiers in Neural Circuits.

Research output: Contribution to journal › Article › peer-review

Twitchy, the Drosophila orthologue of the ciliary gating protein FBF1/dyf-19, is required for coordinated locomotion and male fertility

Hodge, S., Marley, R., Baines, R., MacDougall, L. & Hafen, E., 6 Aug 2021, In: Biology Open. 10, 8, bio058531.

Research output: Contribution to journal › Article › peer-review

Open Access

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148 Downloads (Pure)

2020

Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age- and combination-specific phenotypic profiles in Drosophila

Hahn, I., Sharpe, J., Voelzmann, A., Munro, A., Baines, R., Pickering-Brown, S. & West, R., 7 Sept 2020, In: Acta Neuropathologica Communications. 8, 158

Research output: Contribution to journal › Article › peer-review

Open Access

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67 Downloads (Pure)

Small Molecules Restore Bestrophin 1 Expression and Function of Both Dominant and Recessive Bestrophinopathies in Patient-Derived Retinal Pigment Epithelium.

Liu, J., Taylor, R. L., Baines, R., Swanton, E., Freeman, S., Corneo, B., Patel, A., Marmorstein, A., Knudson, T., Black, G. & Manson, F., 18 May 2020, In: Investigative ophthalmology & visual science. 61, 5, 28.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

A poly-glutamine region in the Drosophila vesicular acetylcholine transporter dictates fill-level of cholinergic synaptic vesicles

Vernon, S., Goodchild, J. & Baines, R., 2019, In: eNeuro.

Research output: Contribution to journal › Article › peer-review

Open Access

Myocyte enhancer factor-2 and p300 interact to regulate expression of the homeostatic regulator Pumilio in Drosophila

Lin, W-H. & Baines, R., 28 Jan 2019, In: European Journal of Neuroscience. 50, 1, p. 1727-1740

Research output: Contribution to journal › Article › peer-review

Open Access

Split-QF system for fine-tuned transgene expression in Drosophila

Riabinina, O., Vernon, S., Dickson, B. J. & Baines, R., 2019, In: Genetics.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

An RNAi-mediated screen identifies novel targets for next-generation antiepileptic drugs based on increased expression of the homeostatic regulator Pumilio

Lin, W-H., He, M., Fan, Y. N. & Baines, R., 2018, In: Journal of Neurogenetics. 32, 2

Research output: Contribution to journal › Article › peer-review

Open Access

Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila

Oswald, M. C. W., Brooks, P. S., Zwart, M. F., Mukherjee, A., West, R. J. H., Giachello, C. N. G., Morarach, K., Baines, R. A., Sweeney, S. T. & Landgraf, M., 12 Dec 2018, In: eLife. 7, e39393.

Research output: Contribution to journal › Article › peer-review

Open Access

Regulation of voltage-gated sodium channel expression, control of excitability and implications for seizure generation

Baines, R. & Lin, W-H., 2018, In: Current Opinion in Physiology.

Research output: Contribution to journal › Article › peer-review

Open Access

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The VAChT^Y49N mutation provides insecticide-resistance but perturbs evoked cholinergic neurotransmission in Drosophila

Vernon, S., Goodchild, J. & Baines, R., 2018, In: PLoS ONE. 13, 9, e0203852.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Mutations in Membrin/GOSR2 Reveal Stringent Secretory Pathway Demands of Dendritic Growth and Synaptic Integrity

Praschberger, R., Lowe, S. A., Malintan, N. T., Giachello, C. N. G., Patel, N., Houlden, H., Kullmann, D. M., Baines, R. A., Usowicz, M. M., Krishnakumar, S. S., Hodge, J. J. L., Rothman, J. E. & Jepson, J. E. C., 3 Oct 2017, In: Cell Reports. 21, 1, p. 97-109 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Regulation of motoneuron excitability and the setting of homeostatic limits

Giachello, C. & Baines, R., Apr 2017, In: Current opinion in neurobiology. 43, p. 1-6 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Seizure control through genetic and pharmacological manipulation of Pumilio in Drosophila: A key component of neuronal homeostasis

Lin, W. H., Giachello, C. N. G. & Baines, R. A., 1 Feb 2017, In: DMM Disease Models and Mechanisms. 10, 2, p. 141-150 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

Calcium Imaging of Neuronal Activity in Drosophila Can Identify Anticonvulsive Compounds.

Streit, A. K., Fan, Y. N., Masullo, L. & Baines, R. A., 2016, In: P L o S One. 11, 2

Research output: Contribution to journal › Article › peer-review

Central cholinergic synaptic vesicle loading obeys the set-point model in Drosophila.

Cash, F., Vernon, S. W., Phelan, P., Goodchild, J. & Baines, R. A., 1 Feb 2016, In: Journal of Neurophysiology. 115, 2

Research output: Contribution to journal › Article › peer-review

Magnetic fields modulate blue light-dependent regulation of neuronal firing by cryptochrome

Giachello, C., Scrutton, N., Jones, A. & Baines, R., 19 Oct 2016, In: Journal of Neuroscience. 36, 42, p. 10742-10749

Research output: Contribution to journal › Article › peer-review

Open Access

Restoration of mutant bestrophin-1 expression, localisation and function in a polarised epithelial cell model

Uggenti, C., Briant, K., Streit, A-K., Thomson, S., Koay, Y. H., Baines, R., Swanton, L. & Manson, F. D., 1 Nov 2016, In: DMM Disease Models and Mechanisms. 9, 11, p. 1317-1328 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2015

Distal spike initiation zone location estimation by morphological simulation of ionic current filtering demonstrated in a novel model of an identified Drosophila motoneuron.

Günay, C., Sieling, F. H., Dharmar, L., Lin, W-H., Wolfram, V., Marley, R., Baines, R. A. & Prinz, A. A., May 2015, In: P L o S Computational Biology (Online). 11, 5

Research output: Contribution to journal › Article › peer-review

Epilepsy research methods update: Understanding the causes of epileptic seizures and identifying new treatments using non-mammalian model organisms.

Cunliffe, V. T., Baines, R. A., Giachello, C. N. G., Lin, W-H., Morgan, A., Reuber, M., Russell, C., Walker, M. C. & Williams, R. S. B., Jan 2015, In: Seizure. 24

Research output: Contribution to journal › Article › peer-review

Inappropriate Neural Activity during a Sensitive Period in Embryogenesis Results in Persistent Seizure-like Behavior.

Giachello, C. N. G. & Baines, R. A., 16 Nov 2015, In: Current Biology. 25, 22, p. 2964–2968

Research output: Contribution to journal › Article › peer-review

Seizure suppression through manipulating splicing of a voltage-gated sodium channel

Lin, W-H., He, F. & Baines, R. A., 12 Feb 2015, In: Brain. 138, 4, p. 891-901

Research output: Contribution to journal › Article › peer-review

2014

Cryptochrome-dependent magnetic field effect on seizure response in Drosophila larvae

Marley, R., Giachello, C. N. G., Scrutton, N. S., Baines, R. A. & Jones, A. R., 23 Jul 2014, In: Scientific Reports. 4, 5799.

Research output: Contribution to journal › Article › peer-review

Open Access

2013

Blurring the boundaries: Developmental and activity-dependent determinants of neural circuits

Wolfram, V. & Baines, R. A., Oct 2013, In: Trends in neurosciences. 36, 10, p. 610-619 9 p.

Research output: Contribution to journal › Article › peer-review

Innexins ogre and inx2 are required in glial cells for normal postembryonic development of the drosophila central nervous system

Holcroft, C. E., Jackson, W. D., Lin, W. H., Bassiri, K., Baines, R. A. & Phelan, P., 2013, In: Journal of Cell Science. 126, 17, p. 3823-3834 11 p.

Research output: Contribution to journal › Article › peer-review

Pumilio-2 regulates translation of Nav1.6 to mediate homeostasis of membrane excitability

Driscol, H. E., Muraro, N. I., He, M. & Baines, R. A., 2013, In: Journal of Neuroscience. 33, 23, p. 9644-9654 10 p.

Research output: Contribution to journal › Article › peer-review

2012

Activity-dependent alternative splicing increases persistent Sodium current and promotes seizure

Baines, R. A., Lin, W. H., Günay, C., Marley, R. & Prinz, A. A., 23 May 2012, In: Journal of Neuroscience. 32, 21, p. 7267-7277 10 p.

Research output: Contribution to journal › Article › peer-review

The LIM-Homeodomain Protein Islet Dictates Motor Neuron Electrical Properties by Regulating K + Channel Expression

Wolfram, V., Southall, T. D., Brand, A. H. & Baines, R. A., 23 Aug 2012, In: Neuron. 75, 4, p. 663-674 11 p.

Research output: Contribution to journal › Article › peer-review

2011

Dissection of first- and second-instar Drosophila larvae for electrophysiological recording from neurons: The flat (or fillet) preparation

Marley, R. & Baines, R. A., Sept 2011, In: Cold Spring Harbor Protocols. 6, 9, p. 1115-1119 4 p.

Research output: Contribution to journal › Article › peer-review

2010

Drosophila glial glutamate transporter Eaat1 is regulated by fringe-mediated notch signaling and is essential for larval locomotion

Stacey, S. M., Muraro, N. I., Peco, E., Labbe, A., Thomas, G. B., Baines, R. A. & Van Meyel, D. J., 27 Oct 2010, In: Journal of Neuroscience. 30, 43, p. 14446-14457 11 p.

Research output: Contribution to journal › Article › peer-review

2009

Alternative splicing in the voltage-gated sodium channel DmNav regulates activation, inactivation, and persistent current

Lin, W. H., Wright, D. E., Muraro, N. I. & Baines, R. A., Sept 2009, In: Journal of Neurophysiology. 102, 3, p. 1994-2006 12 p.

Research output: Contribution to journal › Article › peer-review

Richard Baines, PhD

Research output

Search results