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Richard Byers

Dr

 https://orcid.org/0000-0003-0796-0365

Personal profile

Biography

After general medical training, including an intercalated BSc in Anatomy and MSc in Cell and Structural Biology, I trained as a histopathologist and did a PhD in molecular biology, specifically in bone biology. Since then I have developed a diagnostic and research interest in haematopathology and my specialist diagnostic clinical interest is in leukaemia and lymphoma. I am Reader in Pathology at the University of Manchester and Consultant Haematopathologist at Manchester Royal Infirmary. 

Research interests

My research is in the field of translational molecular pathology and is focused on application of microarray identified prognostic gene signatures to routine diagnostic use. This is being done using by;

  1. real-time PCR measurement of gene signatures in globally amplified polyA cDNA
  2. development of quantum-dot (qdot) based multiplex fluorescent in-situ hybridisation (ISH).
The former approach has been used in acute leukaemia and lymphoma and is being piloted in pancreatic cancer and prostate cancer. Qdot based multiple ISH, developed during a research sabbatical at the Broad Institute, MIT, is being used to measure prognostic genes in acute leukaemia and to investigate apoptosis and angiogenesis. The qdot work also aims to quantitate fluoresence gene expression signals for the first time in clinical tissue samples. These techniques are applicable to routinely processed clinical material and are generic in nature enabling extension to any tumour type. As such they represent a novel platform for the diagnostic measurement of prognostic genes.

I was visiting professor at the Broad Institute of Harvard & MIT 2003-2004 and continue to collaborate with the group. I am Chair of the Molecular Pathology Group of the Pathological Society of Great Britain and Ireland and co-organiser of the first Pathological Society Summer School, in Molecular Pathology. I have given several invited lectures on Qdot ISH and IHC (including Harvard, Boston
2003, Christie Hospital, Manchester 2004, St Bart's, London 2006, Ventana Symposium, Paris 2006, University of Newcastle 2007) and am molecular pathologist for the Clinical Experimental Pharmacology Group, PICR, Manchester. I am a reviewer for the Journal of Pathology, Histopathology, British Journal of Haematology and Journal of Clinical Pathology.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Beacons, Institutes and Platforms

  • Digital Futures
  • Christabel Pankhurst Institute
  • Manchester Cancer Research Centre

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