Robert Hawkins

2022

Acute and chronic cardiopulmonary effects of high dose interleukin-2 therapy: an observational magnetic resonance imaging study

Lagan, J., Naish, J. H., Campbell, C., Chow, S., Pillai, M., Bradley, J., Francis, L., Clark, D., Macnab, A., Dobson, R., Schelbert, E. B., Schmitt, M., Hawkins, R. & Miller, C. A., 24 May 2022, (Accepted/In press) In: Diagnostics.

Research output: Contribution to journal › Article › peer-review

Clinical feasibility and treatment outcomes with nonselected autologous tumor-infiltrating lymphocyte therapy in patients with advanced cutaneous melanoma

Pillai, M., Jiang, Y., Lorigan, P. C., Thistlethwaite, F. C., Thomas, M., Kirillova, N., Bridgeman, J. S., Kueberuwa, G., Biswas, S., Velazquez, P., Chonzi, D., Guest, R. D., Roberts, Z. J. & Hawkins, R. E., 2022, In: American journal of cancer research. 12, 8, p. 3967-3984 18 p.

Research output: Contribution to journal › Article › peer-review

2021

Clinical Feasibility and Treatment Outcomes with Unselected Autologous Tumor Infiltrating Lymphocyte Therapy in Patients with Advanced Cutaneous Melanoma.

Hawkins, R. E., Jiang, Y., Lorigan, P. C., Thistlethwaite, F. C., Pillai, M., Thomas, M., Kirilova, N., Bridgeman, J. S., Kueberuwa, G., Guest, R. S. & Roberts, Z. J., Jul 2021, In: Cancer Research. 81, 13

Research output: Contribution to journal › Meeting Abstract › peer-review

2020

Massively parallel interrogation and mining of natively paired human TCRαβ repertoires

Spindler, M. J., Nelson, A. L., Wagner, E. K., Oppermans, N., Bridgeman, J. S., Heather, J. M., Adler, A. S., Asensio, M. A., Edgar, R. C., Lim, Y. W., Meyer, E. H., Hawkins, R. E., Cobbold, M. & Johnson, D. S., 16 Mar 2020, In: Nature biotechnology. 38, 5, p. 609-619 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Atezolizumab plus bevacizumab versus sunitinib in patients with previously untreated metastatic renal cell carcinoma (IMmotion151): a multicentre, open-label, phase 3, randomised controlled trial

Rini, B. I., Powles, T., Atkins, M. B., Escudier, B., McDermott, D. F., Suarez, C., Bracarda, S., Stadler, W. M., Donskov, F., Lee, J. L., Hawkins, R., Ravaud, A., Alekseev, B., Staehler, M., Uemura, M., De Giorgi, U., Mellado, B., Porta, C., Melichar, B., Gurney, H., & 12 othersBedke, J., Choueiri, T. K., Parnis, F., Khaznadar, T., Thobhani, A., Li, S., Piault-Louis, E., Frantz, G., Huseni, M., Schiff, C., Green, M. C. & Motzer, R. J., 15 Jun 2019, In: The Lancet. 393, 10189, p. 2404-2415 12 p.

Research output: Contribution to journal › Article › peer-review

Prospective Observational Study of Pazopanib in Patients with Advanced Renal Cell Carcinoma (PRINCIPAL Study)

Schmidinger, M., Bamias, A., Procopio, G., Hawkins, R., Sanchez, A. R., Vázquez, S., Srihari, N., Kalofonos, H., Bono, P., Pisal, C. B., Hirschberg, Y., Dezzani, L., Ahmad, Q. & Jonasch, E., 2019, In: Oncologist.

Research output: Contribution to journal › Article › peer-review

Radiological Response Heterogeneity Is of Prognostic Significance in Metastatic Renal Cell Carcinoma Treated with Vascular Endothelial Growth Factor-targeted Therapy

Hall, P. E., Shepherd, S. T. C., Brown, J., Larkin, J., Jones, R., Ralph, C., Hawkins, R., Chowdhury, S., Boleti, E., Bahl, A., Fife, K., Webb, A., Crabb, S. J., Geldart, T., Hill, R., Dunlop, J., McLaren, D., Ackerman, C., Wimalasingham, A., Beltran, L., & 2 othersNathan, P. & Powles, T., 2019, In: European Urology Focus.

Research output: Contribution to journal › Article › peer-review

2018

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells

Kueberuwa, G., Zheng, W., Kalaitsidou, M., Gilham, D. & Hawkins, R., 2018, In: Journal of Visualized Experiments. 140

Research output: Contribution to journal › Article › peer-review

Open Access

Ex vivo expanded Tumour Infiltrating Lymphocytes (TILs) from ovarian cancer patients release anti-tumour cytokines in response to autologous primary ovarian cancer cells

Owens, G., Price, M., Cheadle, E., Hawkins, R., Gilham, D. & Edmondson, R., Oct 2018, In: Cancer Immunology, Immunotherapy.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Adjuvant Weekly Girentuximab Following Nephrectomy for High-Risk Renal Cell Carcinoma: The ARISER Randomized Clinical Trial

Chamie, K., Donin, N. M., Klöpfer, P., Bevan, P., Fall, B., Wilhelm, O., Störkel, S., Said, J., Gambla, M., Hawkins, R. E., Jankilevich, G., Kapoor, A., Kopyltsov, E., Staehler, M., Taari, K., Wainstein, A. J. A., Pantuck, A. J. & Belldegrun, A. S., 1 Jul 2017, In: JAMA oncology. 3, 7, jamaoncol.2016.4419.

Research output: Contribution to journal › Article › peer-review

CCR7+ selected gene-modified T cells maintain a central memory phenotype and display enhanced persistence in peripheral blood in vivo

Kueberuwa, G., Gornall, H., Alcantar Orozco, E. M., Bouvier, D., Kapacee, Z. A., Hawkins, R. & Gilham, D., Dec 2017, In: Journal for ImmunoTherapy of Cancer. 5, 14

Research output: Contribution to journal › Article › peer-review

Open Access

CD19 CAR T-cells expressing IL-12 eradicate lymphoma in fully lymphoreplete mice through induction of host immunity

Kueberuwa, G., Kalaitsidou, M., Cheadle, E., Hawkins, R. & Gilham, D., 2017, In: Molecular therapy oncolytics.

Research output: Contribution to journal › Article › peer-review

Open Access

Innovative regenerative medicines in the EU: A better future in evidence?

Corbett, M. S., Webster, A., Hawkins, R. & Woolacott, N., 8 Mar 2017, In: BMC Medicine. 15, 1, 49.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

High-dose interleukin2 – a 10-year single-site experience in the treatment of metastatic renal cell carcinoma: careful selection of patients gives an excellent outcome

Chow, S., Galvis, V., Pillai, M., Leach, R., Keene, E., Spencer-Shaw, A., Shablak, A., Shanks, J., Liptrot, T., Thistlethwaite, F. & Hawkins, R., 18 Oct 2016, In: Journal for ImmunoTherapy of Cancer. 4, 67

Research output: Contribution to journal › Article › peer-review

Open Access

Randomized Open-Label Phase II Trial of Apitolisib (GDC-0980), a Novel Inhibitor of the PI3K/Mammalian Target of Rapamycin Pathway, Versus Everolimus in Patients With Metastatic Renal Cell Carcinoma

Powles, T., Lackner, M. R., Oudard, S., Escudier, B., Ralph, C., Brown, J. E., Hawkins, R. E., Castellano, D., Rini, B. I., Staehler, M. D., Ravaud, A., Lin, W., O'Keeffe, B., Wang, Y., Lu, S., Spoerke, J. M., Huw, L-Y., Byrtek, M., Zhu, R., Ware, J. A., & 1 othersMotzer, R. J., 10 May 2016, In: Journal of Clinical Oncology. 34, 14, p. 1660-8 9 p.

Research output: Contribution to journal › Article › peer-review

Tumour–microenvironment mediates resistance to immuno and targeted therapies in acral melanoma

Lee, R., Girotti, M. R., Khandelwal, G., Baenke, F., Viros, A., Mandal, A., Bridgeman, J., Galvani, E., Gremel, G., Kalaitsidou, M., Ashton, G., Peset, I., Smith, M., Hawkins, R., Fusi, A., Miller, C., Gilham, D., Dhomen, N., Lorigan, P. & Marais, R., Jul 2016, In: European Journal of Cancer. 61, p. S188

Research output: Contribution to journal › Article › peer-review

2015

Adoptive Cell Therapy for metastatic melanoma: A UK centre experience

Pillai, M. R., Guest, R., Kirillova, N., Chow, S., Lorigan, P. & Hawkins, R. E., 2015, In: Journal of Clinical Oncology. 33, 15, p. 9060 1 p.

Research output: Contribution to journal › Article › peer-review

Adoptive T-cell therapy for cancer in the United kingdom: a review of activity for the British Society of Gene and Cell Therapy annual meeting 2015

Gilham, D. E., Anderson, J., Bridgeman, J. S., Hawkins, R. E., Exley, M. A., Stauss, H., Maher, J., Pule, M., Sewell, A. K., Bendle, G., Lee, S., Qasim, W., Thrasher, A. & Morris, E., 2015, In: Hum Gene Ther. 26, 5, p. 276-85 190 p.

Research output: Contribution to journal › Article › peer-review

Efficient and reproducible generation of tumour-infiltrating lymphocytes for renal cell carcinoma

Baldan, V., Griffiths, R., Hawkins, R. E. & Gilham, D. E., 2015, In: Br J Cancer. 112, 9, p. 1510-8 1501 p.

Research output: Contribution to journal › Article › peer-review

Integrating radiation therapy with emerging systemic therapies: Lessons from a patient with cerebral radionecrosis, spinal cord myelopathy, and radiation pneumonitis.

Flaum, N., Lorigan, P., Whitfield, G., Hawkins, R. E. & Pinkham, M., 22 Oct 2015, In: Practical Radiation Oncology . 6, 2, p. 376-378 2 p., j.prro.2015.10.008.

Research output: Contribution to journal › Article › peer-review

Overcoming the toxicity hurdles of geneticall targetted T Cells

Casucci, M., Hawkins, RE., Dotti, G. & Bondanza, A., Jan 2015, In: Cancer Immunology, Immunotherapy. 64, 1, p. 123-130 7 p.

Research output: Contribution to journal › Article › peer-review

2014

Angiogenesis inhibitor therapies for advanced renal cell carcinoma: toxicity and treatment patterns in clinical practice from a global medical chart review

Oh, WK., McDermott, D., Porta, C., Levy, A., Elaidi, R., Scotte, F., Hawkins, R., Castellano, D., Bellmunt, J., Rha, SY., Sun, JM., Nathan, P., Feinberg, BA., Scott, J., McDermott, R., Ahn, JH., Wagstaff, J., Chang, YH., Ou, YC., Donnellan, P., & 9 othersHuang, CY., McCaffrey, J., Chiang, PH., Chuang, CK., Korves, C., Neary, MP., Diaz, JR., Mehmud, F. & Duh, MS., Nov 2014, In: International Journal of Oncology. 44, 1, p. 5-16 11 p.

Research output: Contribution to journal › Article › peer-review

An open-label extension study to evaluate safety and efficacy of pazopanib in patients with advanced renal cell carcinoma.

Sternberg, CN., Davis, ID., Deen, KC., Sigal, E. & Hawkins, RE., 6 Sept 2014, In: Oncology. 87, 6, p. 342-350 8 p.

Research output: Contribution to journal › Article › peer-review

CAR T cells: driving the road from the laboratory to the clinic

Cheadle, E. J., Gornall, H., Baldan, V., Hanson, V., Hawkins, R. E. & Gilham, D. E., 2014, In: Immunological reviews. 257, 1, p. 91-106 16 p.

Research output: Contribution to journal › Article › peer-review

CD3ζ-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy

Bridgeman, JS., Ladell, K., Sheard, VE., Miners, K., Hawkins, RE., Price, DA. & Gilham, DE., Feb 2014, In: Clinical and experimental immunology. 175, 2, p. 258-267 9 p.

Research output: Contribution to journal › Article › peer-review

Definition and application of good manufacturing process-compliant production of CEA-specific chimeric antigen receptor expressing T-cells for phase I/II clinical trial

Guest, R. D., Kirillova, N., Mowbray, S., Gornall, H., Rothwell, D. G., Cheadle, E. J., Austin, E., Smith, K., Watt, S. M., Kühlcke, K., Westwood, N., Thistlethwaite, F., Hawkins, R. E. & Gilham, D. E., 1 Feb 2014, In: Cancer Immunology, Immunotherapy. 63, 2, p. 133-145 12 p., 10.1007/s00262-013-1492-9.

Research output: Contribution to journal › Article › peer-review

Differential role of Th1 and Th2 cytokines in autotoxicity driven by CD19-specific second-generation chimeric antigen receptor T cells in a mouse model

Cheadle, E. J., Sheard, V., Rothwell, D. G., Bridgeman, J. S., Ashton, G., Hanson, V., Mansoor, A. W., Hawkins, R. E. & Gilham, D. E., 2014, In: J Immunol. 192, 8, p. 3654-65 12 p.

Research output: Contribution to journal › Article › peer-review

High-dose interleukin 2-induced myocarditis: can myocardial damage reversibility be assessed by cardiac MRI?

Chow, S., Cove-Smith, L., Schmitt, M. & Hawkins, R., Jun 2014, In: Journal of Immunotherapy. 37, 5, p. 304-308 4 p.

Research output: Contribution to journal › Article › peer-review

Immunohistochemical assessment of NY-ESO-1 expression in esophageal adenocarcinoma resection specimens

Hayes, SJ., Hng, KN., Clark, P., Thistlethwaite, F., Hawkins, RE. & Ang, Y., 14 Apr 2014, In: World Journal of Gastroenterology. 20, 14, p. 4011-4016 5 p.

Research output: Contribution to journal › Article › peer-review

Impact of adverse events, treatment modifications, and dose intensity on survival among patients with advanced renal cell carcinoma treated with first-line sunitinib: a medical chart review across ten centers in five European countries.

Porta, C., Levy, A., Hawkins, R., Castellano, D., Bellmunt, J., Nathan, P., McDermott, R., Wagstaff, J., Donnellan, P., McCaffrey, J., Vekeman, F., Neary, MP., Diaz, J., Mehmud, F. & Duh, MS., Dec 2014, In: Cancer Medicine. 3, 6, p. 1517-1526 9 p.

Research output: Contribution to journal › Article › peer-review

In vitro effect of IL-2 in combination with pazopanib or sunitinib on lymphocytes function and apoptosis of RCC cells.

Shablak, A., Gilham, DE., Hawkins, RE. & Elkord, E., Aug 2014, In: Expert opinion on pharmacotherapy. 15, 11, p. 1489-1499 10 p.

Research output: Contribution to journal › Article › peer-review

Naptumomab estafenatox: targeted immunotherapy with a novel immunotoxin.

Eisen, T., Hedlund, G., Forsberg, G. & Hawkins, R., Feb 2014, In: Current Oncology Reports (Print). 16, 2, p. 370-371 1 p.

Research output: Contribution to journal › Article › peer-review

Randomized, controlled, double-blind, cross-over trial assessing treatment preference for pazopanib versus sunitinib in patients with metastatic renal cell carcinoma: PISCES Study.

Escudier, B., Porta, C., Bono, P., Powles, T., Eisen, T., Sternberg, CN., Gschwend, JE., De, G. U., Parikh, O., Hawkins, R., Sevin, E., Négrier, S., Khan, S., Diaz, J., Redhu, S., Mehmud, F. & Cella, D., May 2014, In: Journal of Clinical Oncology. 32, 14, p. 1412-1418 6 p.

Research output: Contribution to journal › Article › peer-review

2013

A randomised, double-blind phase III study of pazopanib in patients with advanced and/or metastatic renal cell carcinoma: Final overall survival results and safety update

Sternberg, CN., Hawkins, RE., Wagstaff, J., Salman, P., Mardiak, J., Barrios, CH., Zarba, JJ., Gladkov, OA., Lee, E., Szczylik, C., McCann, L., Rubin, SD., Chen, M. & Davis, ID., 2013, In: European Journal of Cancer. 49, 6, p. 1287-1296 9 p.

Research output: Contribution to journal › Article › peer-review

Isolation of tumor antigen-specific single-chain variable fragments using a chimeric antigen receptor bicistronic retroviral vector in a Mammalian screening protocol.

Lipowska-Bhalla, G., Gilham, DE., Hawkins, RE. & Rothwell, D. G., Dec 2013, In: Human Gene Therapy. Methods. 24, 6, p. 381-391 10 p.

Research output: Contribution to journal › Article › peer-review

Pazopanib versus sunitinib in metastatic renal-cell carcinoma

Motzer, R. J., Hutson, T. E., Cella, D., Reeves, J., Hawkins, R., Guo, J., Nathan, P., Staehler, M., Souza, P., Merchan, J. R., Boleti, E., Fife, K., Jin, J., Jones, R., Uemura, H., De Giorgi, U., Harmenberg, U., Wang, J., Sternberg, C. N., Deen, K., & 5 othersMcCann, L., Hackshaw, M. D., Crescenzo, R., Pandite, L. N. & Choueiri, T. K., 2013, In: New England Journal Of Medicine. 369, 8, p. 722-731 9 p.

Research output: Contribution to journal › Article › peer-review

2012

Cancer classification using the Immunoscore: A worldwide task force

Galon, J., Pagès, F., Marincola, F. M., Angell, H. K., Thurin, M., Lugli, A., Zlobec, I., Berger, A., Bifulco, C., Botti, G., Tatangelo, F., Britten, C. M., Kreiter, S., Chouchane, L., Delrio, P., Arndt, H., Asslaber, M., Maio, M., Masucci, G. V., Mihm, M., & 44 othersVidal-Vanaclocha, F., Allison, J. P., Gnjatic, S., Hakansson, L., Huber, C., Singh-Jasuja, H., Ottensmeier, C., Zwierzina, H., Laghi, L., Grizzi, F., Ohashi, P. S., Shaw, P. A., Clarke, B. A., Wouters, B. G., Kawakami, Y., Hazama, S., Okuno, K., Wang, E., O'Donnell-Tormey, J., Lagorce, C., Pawelec, G., Nishimura, M. I., Hawkins, R., Lapointe, R., Lundqvist, A., Khleif, S. N., Ogino, S., Gibbs, P., Waring, P., Sato, N., Torigoe, T., Itoh, K., Patel, P. S., Shukla, S. N., Palmqvist, R., Nagtegaal, I. D., Wang, Y., D'Arrigo, C., Kopetz, S., Sinicrope, F. A., Trinchieri, G., Gajewski, T. F., Ascierto, P. A. & Fox, B. A., 3 Oct 2012, In: Journal of Translational Medicine. 10, 1, 205.

Research output: Contribution to journal › Article › peer-review

CAR-T cells and solid tumors: Tuning T cells to challenge an inveterate foe

Gilham, D. E., Debets, R., Pule, M., Hawkins, R. E. & Abken, H., Jul 2012, In: Trends in molecular medicine. 18, 7, p. 377-384 7 p.

Research output: Contribution to journal › Article › peer-review

Cediranib monotherapy in patients with advanced renal cell carcinoma: Results of a randomised phase II study

Mulders, P., Hawkins, R., Nathan, P., De Jong, I., Osanto, S., Porfiri, E., Protheroe, A., Van Herpen, C. M. L., Mookerjee, B., Pike, L., Jürgensmeier, J. M. & Gore, M. E., Mar 2012, In: European Journal of Cancer. 48, 4, p. 527-537 10 p.

Research output: Contribution to journal › Article › peer-review

Docetaxel combined with irinotecan or 5-fluorouracil in patients with advanced oesophago-gastric cancer: A randomised phase II study

Roy, A., Cunningham, D., Hawkins, R., Sörbye, H., Adenis, A., Barcelo, J. R., Lopez-Vivanco, G., Adler, G., Canon, J. L., Lofts, F., Castanon, C., Fonseca, E., Rixe, O., Aparicio, J., Cassinello, J., Nicolson, M., Mousseau, M., Schalhorn, A., D'Hondt, L., Kerger, J., & 5 othersHossfeld, D. K., Garcia Giron, C., Rodriguez, R., Schoffski, P. & Misset, J. L., 24 Jul 2012, In: British Journal of Cancer. 107, 3, p. 435-441 6 p.

Research output: Contribution to journal › Article › peer-review

Targeted immunotherapy of cancer with CAR T cells: Achievements and challenges

Lipowska-Bhalla, G., Gilham, D. E., Hawkins, R. E. & Rothwell, D. G., Jul 2012, In: Cancer Immunology, Immunotherapy. 61, 7, p. 953-962 9 p.

Research output: Contribution to journal › Article › peer-review

2011

An international expanded access programme of everolimus: Addressing safety and efficacy in patients with metastatic renal cell carcinoma who progress after initial vascular endothelial growth factor receptor-tyrosine kinase inhibitor therapy

Bodrogi, I. & The REACT Study Group, 29 Jul 2011, In: Eur J Cancer.

Research output: Contribution to journal › Article › peer-review

Expanded subpopulation of FoxP3+ T regulatory cells in renal cell carcinoma co-express Helios, indicating they could be derived from natural but not induced Tregs

Elkord, E., Sharma, S., Burt, D. J. & Hawkins, R. E., Sept 2011, In: Clinical Immunology. 140, 3, p. 218-222 4 p.

Research output: Contribution to journal › Article › peer-review

High-dose interleukin-2 can produce a high rate of response and durable remissions in appropriately selected patients with metastatic renal cancer

Shablak, A., Sikand, K., Shanks, J. H., Thistlethwaite, F., Spencer-Shaw, A. & Hawkins, R. E., Jan 2011, In: Journal of Immunotherapy. 34, 1, p. 107-112 5 p.

Research output: Contribution to journal › Article › peer-review

Ligation of CD2 co-stimulatory receptor enhances IL-2 production from first generation chimeric antigen receptor T cells

Cheadle, EJ., Rothwell, DG., Bridgeman, JS., Sheard, VE., Hawkins, RE. & Gilham, DE., Dec 2011, In: Gene Ther.

Research output: Contribution to journal › Article › peer-review

Management of a new isolated metastasis during sunitinib treatment in renal cell carcinoma patients: A lesson from two cases

Shablak, A., O'Dwyer, J., Hawkins, R. & Board, R., Mar 2011, In: Urologia Internationalis. 86, 2, p. 245-248 3 p.

Research output: Contribution to journal › Article › peer-review

MVA-5T4-induced immune responses are an early marker of efficacy in renal cancer patients

Harrop, R., Shingler, W. H., McDonald, M., Treasure, P., Amato, R. J., Hawkins, R. E., Kaufman, H. L., De Belin, J., Kelleher, M., Goonewardena, M. & Naylor, S., Jun 2011, In: Cancer Immunology, Immunotherapy. 60, 6, p. 829-837 8 p.

Research output: Contribution to journal › Article › peer-review

Sunitinib in metastatic renal cell carcinoma patients with brain metastases

Gore, M. E., Hariharan, S., Porta, C., Bracarda, S., Hawkins, R., Bjarnason, G. A., Oudard, S., Lee, S. H., Carteni, G., Nieto, A., Yuan, J. & Szczylik, C., 1 Feb 2011, In: Cancer. 117, 3, p. 501-509 8 p.

Research output: Contribution to journal › Article › peer-review

2010

Amplification of epidermal growth factor receptor gene in renal cell carcinoma

El-Hariry, I., Powles, T., Lau, M. R., Sternberg, C. N., Ravaud, A., von der Maase, H., Zantl, N., Harper, P., Rolland, F., Audhuy, B., Barthel, F., Machiels, J. P., Patel, P., Kreuser, E. D. & Hawkins, R. E., Mar 2010, In: European Journal of Cancer. 46, 5, p. 859-862 3 p.

Research output: Contribution to journal › Article › peer-review

A phase I/II study of siltuximab (CNTO) an anti-interleukin-6 monoclonal antibody in metastatic renal cell cancer

Rossi, JF., Negrier, S., James, ND., Kocak, I., Hawkins, R., Davis, H., Prabhakar, U., Qin, X., Mulders, P. & Berns, B., 2010, In: Br J Cancer. 38, 6, p. 1154-1162 8 p.

Research output: Contribution to journal › Article › peer-review

Robert Hawkins, MA MB BS PhD FRCP

Research output

Search results