Robert Hawkins

2010

Do CARs need a driver's license? Adoptive cell therapy with chimeric antigen receptor-redirected T cells has caused serious adverse events

Büning, H., Uckert, W., Cichutek, K., Hawkins, R. E. & Abken, H., 1 Sept 2010, In: Human Gene Therapy. 21, 9, p. 1039-1042 3 p.

Research output: Contribution to journal › Article › peer-review

Functional expression of secreted proteins from a bicistronic retroviral cassette based on foot-and-mouth disease virus 2A can be position dependent

Rothwell, D. G., Crossley, R., Bridgeman, J. S., Sheard, V., Zhang, Y., Sharp, T. V., Hawkins, R. E., Gilham, D. E. & McKay, T. R., 1 Nov 2010, In: Human Gene Therapy. 21, 11, p. 1631-1637 6 p.

Research output: Contribution to journal › Article › peer-review

Gene delivery of a mutant TGFbeta3 reduces markers of scar tissue formation after cutaneous wounding

Waddington, SN., Crossley, R., Sheard, V., Howe, SJ., Buckley, SM., Coughlan, L., Gilham, DE., Hawkins, RE. & McKay, TR., 2010, In: Mol Ther. 38, 6, p. 1489-1493 4 p.

Research output: Contribution to journal › Article › peer-review

Natural expression of the CD19 antigen impacts the long-term engraftment but not antitumor activity of CD19-specific engineered T cells

Cheadle, E. J., Hawkins, R. E., Batha, H., O'Neill, A. L., Dovedi, S. J. & Gilham, D. E., 15 Feb 2010, In: Journal of Immunology. 184, 4, p. 1885-1896 11 p.

Research output: Contribution to journal › Article › peer-review

Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial

Sternberg, C. N., Davis, I. D., Mardiak, J., Szczylik, C., Lee, E., Wagstaff, J., Barrios, C. H., Salman, P., Gladkov, O. A., Kavina, A., Zarbá, J. J., Chen, M., McCann, L., Pandite, L., Roychowdhury, D. F. & Hawkins, R. E., 20 Feb 2010, In: Journal of Clinical Oncology. 28, 6, p. 1061-1068 7 p.

Research output: Contribution to journal › Article › peer-review

Vaccination of metastatic renal cancer patients with MVA-5T4: A randomized, double-blind, placebo-controlled phase III study

Amato, R. J., Hawkins, R. E., Kaufman, H. L., Thompson, J. A., Tomczak, P., Szczylik, C., McDonald, M., Eastty, S., Shingler, W. H., De Belin, J., Goonewardena, M., Naylor, S. & Harrop, R., 15 Nov 2010, In: Clinical Cancer Research. 16, 22, p. 5539-5547 8 p.

Research output: Contribution to journal › Article › peer-review

2009

5T4 as a target for immunotherapy in renal cell carcinoma

Elkord, E., Shablak, A., Stern, P. L. & Hawkins, R. E., Dec 2009, In: Expert Review of Anticancer Therapy. 9, 12, p. 1705-1709 4 p.

Research output: Contribution to journal › Article › peer-review

Vaccination of Patients with Metastatic Renal Cancer with Modified Vaccinia Ankara Encoding the Tumor Antigen 5T4 (TroVax) Given Alongside Interferon-α

Hawkins, R., Hawkins, R. E., MacDermott, C., Shablak, A., Hamer, C., Thistlethwaite, F., Drury, N. L., Chikoti, P., Shingler, W., Naylor, S. & Harrop, R., May 2009, In: Journal of Immunotherapy. 32, 4, p. 424-429 5 p.

Research output: Contribution to journal › Article › peer-review

2008

An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases.

Elkord, E., Dangoor, A., Drury, N. L., Harrop, R., Burt, D. J., Drijfhout, J. W., Hamer, C., Andrews, D., Naylor, S., Sherlock, D., Hawkins, R. E. & Stern, P. L., Nov 2008, In: Journal of Immunotherapy. 31, 9, p. 820-829 9 p.

Research output: Contribution to journal › Article › peer-review

A phase II open-label study of DHA-paclitaxel (Taxoprexin) by 2-h intravenous infusion in previously untreated patients with locally advanced or metastatic gastric or oesophageal adenocarcinoma

Jones, R. J., Hawkins, R. E., Eatock, M. M., Ferry, D. R., Eskens, F. A. L. M., Wilke, H. & Evans, T. R. J., Mar 2008, In: Cancer Chemotherapy and Pharmacology. 61, 3, p. 435-441 6 p.

Research output: Contribution to journal › Article › peer-review

Lapatinib versus hormone therapy in patients with advanced renal cell carcinoma: A randomized phase III clinical trial

Ravaud, A., Hawkins, R., Gardner, J. P., Von Der Maase, H., Zantl, N., Harper, P., Rolland, F., Audhuy, B., Machiels, J. P., Pétavy, F., Gore, M., Schöffski, P. & El-Hariry, I., 2008, In: Journal of Clinical Oncology. 26, 14, p. 2285-2291 6 p.

Research output: Contribution to journal › Article › peer-review

The combination of cyclophosphamide and human T cells genetically engineered to target CD19 can eradicate established B-cell lymphoma

Cheadle, E. J., Gilham, D. E. & Hawkins, R. E., Jul 2008, In: British Journal of Haematology. 142, 1, p. 65-68 3 p.

Research output: Contribution to journal › Article › peer-review

Vaccination of colorectal cancer patients with TroVax given alongside chemotherapy (5-fluorouracil, leukovorin and irinotecan) is safe and induces potent immune responses

Harrop, R., Drury, N., Shingler, W., Chikoti, P., Redchenko, I., Carroll, M. W., Kingsman, S. M., Naylor, S., Griffiths, R., Steven, N. & Hawkins, R. E., Jul 2008, In: Cancer Immunology, Immunotherapy. 57, 7, p. 977-986 9 p.

Research output: Contribution to journal › Article › peer-review

2007

Adoptive transfer of T(reg) depleted autologous T cells in advanced renal cell carcinoma.

Thistlethwaite, F., Elkord, E., Griffiths, R., Burt, D., Shablak, A., Campbell, J., Gilham, D., Austin, E., Stern, P. & Hawkins, RE., May 2007, In: Cancer Immunol Immunother.

Research output: Contribution to journal › Article › peer-review

CD4(+) T-cell recognition of human 5T4 oncofoetal antigen: implications for initial depletion of CD25(+) T cells.

Elkord, E., Burt, DJ., Drijfhout, JW., Hawkins, RE. & Stern, PL., Jun 2007, In: Cancer Immunol Immunother.

Research output: Contribution to journal › Article › peer-review

Cellular therapy of cancer symposium December 2nd-3rd 2006 Manchester, UK

Thistlethwaite, F. C., Gilham, D. E. & Hawkins, R. E., Jun 2007, In: Cancer Immunology, Immunotherapy. 56, 6, p. 939-942 3 p.

Research output: Contribution to journal › Article › peer-review

Eotaxin-2 and colorectal cancer: A potential target for immune therapy

Cheadle, E. J., Riyad, K., Subar, D., Rothwell, D. G., Ashton, G., Batha, H., Sherlock, D. J., Hawkins, R. E. & Gilham, D. E., 1 Oct 2007, In: Clinical Cancer Research. 13, 19, p. 5719-5728 9 p.

Research output: Contribution to journal › Article › peer-review

2006

Anti-angiogenic therapy in the treatment of advanced renal cell cancer.

Board, RE., Thistlethwaite, FC. & Hawkins, RE., Feb 2006, In: Cancer Treatment Reviews.

Research output: Contribution to journal › Article › peer-review

A phase II study of weekly cisplatin and gemcitabine in patients with advanced pancreatic cancer: Is this a strategy still worth pursuing?

Clayton, A. J., Mansoor, A. W., Jones, E. T., Hawkins, R. E., Saunders, M. P., Swindell, R. & Valle, J. W., Jan 2006, In: Pancreas. 32, 1, p. 51-57 6 p.

Research output: Contribution to journal › Article › peer-review

Cancer vaccines: A clinical perspective

Dangoor, A., Thistlethwaite, F. & Hawkins, R., Jul 2006, In: British journal of hospital medicine. 67, 7, p. 365-369 4 p.

Research output: Contribution to journal › Article › peer-review

Identification of a major histocompatibility complex class I-restricted T-cell epitope in the tumour-associated antigen, 5T4

Redchenko, I., Harrop, R., Ryan, M. G., Hawkins, R. E. & Carroll, M. W., May 2006, In: Immunology. 118, 1, p. 50-57 7 p.

Research output: Contribution to journal › Article › peer-review

Impact of laparotomy and liver resection on the peritoneal concentrations of fibroblast growth factor 2, vascular endothelial growth factor and hepatocyte growth factor

Whitworth, M. K., Sheen, A., Rosa, D. D., Duff, S. E., Ryder, D., Burumdayal, A., Wiener, K., Hawkins, R. E., Saunders, M., Valle, J. W., Sherlock, D. & Jayson, G. C., Jan 2006, In: Journal of Cancer Research and Clinical Oncology. 132, 1, p. 41-4 4 p.

Research output: Contribution to journal › Article › peer-review

Phase I/II trial of Hi-8 PrimeBoost therapeutic vaccine in stage III/IV metastatic melanoma

Hawkins, R., Dangoor, A., Lorigan, P., Keilholz, U., Schadendorf, D., Ottensmeier, C., Smyth, J., Hoffmann, K. & Cripps, M., Sept 2006, In: Melanoma research. 16, Supplement 1, p. S34

Research output: Contribution to journal › Article › peer-review

Phase III trial of 5-fluorouracil and leucovorin plus either 3H1 anti-idiotype monoclonal antibody or placebo in patients with advanced colorectal cancer

Chong, G., Bhatnagar, A., Cunningham, D., Cosgriff, T. M., Harper, P. G., Steward, W., Bridgewater, J., Moore, M., Cassidy, J., Coleman, R., Coxon, F., Redfern, C. H., Jones, J. J., Hawkins, R., Northfelt, D., Sreedharan, S., Valone, F. & Carmichael, J., Mar 2006, In: Annals of Oncology. 17, 3, p. 437-442 5 p.

Research output: Contribution to journal › Article › peer-review

Therapeutic efficacy of engineered T cells targeting CD19 in a B-cell lymphoma model.

Hawkins, R. E., Gilham, D. E., Thistlethwaite, F. C., Radford, J. A. & Cheadle, E. J., 16 Nov 2006, In: Blood. 108, 11, p. 5486 1 p.

Research output: Contribution to journal › Article › peer-review

Vaccination of colorectal cancer patients with modified vaccinia Ankara delivering the tumour antigen 5T4 (TroVax) induces immune responses which correlates with disease control: a phase I/II trial

Harrop, R., Connolly, N., Redchenko, I., Valle, J., Saunders, M., Ryan, MG., Myers, KA., Drury, N., Kingsman, SM., Hawkins, R. & Carroll, MW., 1 Jun 2006, In: Clinical Cancer Research. 12, 11 Pt 1, p. 3416-3424 8 p.

Research output: Contribution to journal › Article › peer-review

2005

A PSP94-derived peptide PCK3145 inhibits MMP-9 secretion and triggers CD44 cell surface shedding: Implication in tumor metastasis

Annabi, B., Bouzeghrane, M., Currie, J. C., Hawkins, R., Dulude, H., Daigneault, L., Ruiz, M., Wisniewski, J., Garde, S., Rabbani, S. A., Panchal, C., Wu, J. J. & Béliveau, R., Sept 2005, In: Clinical and Experimental Metastasis. 22, 5, p. 429-439 10 p.

Research output: Contribution to journal › Article › peer-review

Engineering T cells for cancer therapy

Mansoor, W., Gilham, D. E., Thistlethwaite, F. C. & Hawkins, R. E., 4 Nov 2005, In: British Journal of Cancer. 93, 10, p. 1085-1091 6 p.

Research output: Contribution to journal › Article › peer-review

Engineering T-cells with antibody-based chimeric receptors for effective cancer therapy

Thistlethwaite, F., Mansoor, W., Gilham, D. & Hawkins, R., Feb 2005, In: Current Opinion in Molecular Therapeutics. 7, 1, p. 48-55 7 p.

Research output: Contribution to journal › Article › peer-review

Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours

Ramage, J. K., Davies, A. H. G., Ardill, J., Bax, N., Caplin, M., Grossman, A., Hawkins, R., McNicol, A. M., Reed, N., Sutton, R., Thakker, R., Aylwin, S., Breen, D., Britton, K., Buchanan, K., Corrie, P., Gillams, A., Lewington, V., McCance, D., Meeran, K., & 1 othersWatkinson, A., 2005, In: Gut. 54, 4, p. -v16

Research output: Contribution to journal › Article › peer-review

Killing of non-Hodgkin lymphoma cells by autologous CD19 engineered T cells

Hawkins, R., Cheadle, E. J., Gilham, D. E., Thistlethwaite, F. C., Radford, J. A. & Hawkins, R. E., May 2005, In: British Journal of Haematology. 129, 3, p. 322-332 10 p.

Research output: Contribution to journal › Article › peer-review

Phase III study of 5FU, etoposide and leucovorin (FELV) compared to epirubicin, cisplatin and 5FU (ECF) in previously untreated patients with advanced biliary cancer

Rao, S., Cunningham, D., Hawkins, R. E., Hill, M. E., Smith, D., Daniel, F., Ross, P. J., Oates, J. & Norman, A. R., 9 May 2005, In: British Journal of Cancer. 92, 9, p. 1650-1654 4 p.

Research output: Contribution to journal › Article › peer-review

Phase II study of troxacitabine in chemotherapy-naïve patients with advanced cancer of the pancreas

Lapointe, R., Létourneau, R., Steward, W., Hawkins, R. E., Batist, G., Vincent, M., Whittom, R., Eatock, M., Jolivet, J. & Moore, M., Feb 2005, In: Annals of Oncology. 16, 2, p. 289-293 4 p.

Research output: Contribution to journal › Article › peer-review

Recombinant modified vaccinia Ankara primes functionally activated CTL specific for a melanoma tumor antigen epitope in melanoma patients with a high risk of disease recurrence

Smith, C. L., Dunbar, P. R., Mirza, F., Palmowski, M. J., Shepherd, D., Gilbert, S. C., Coulie, P., Schneider, J., Hoffman, E., Hawkins, R., Harris, A. L. & Cerundolo, V., 10 Jan 2005, In: International Journal of Cancer. 113, 2, p. 259-266 7 p.

Research output: Contribution to journal › Article › peer-review

Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes

Tew, S. R., Li, Y., Pothancharoen, P., Tweats, L. M., Hawkins, R. E. & Hardingham, T. E., Jan 2005, In: Osteoarthritis and Cartilage. 13, 1, p. 80-89 9 p.

Research output: Contribution to journal › Article › peer-review

Safety and tolerability of PCK3145, a synthetic peptide derived from prostate secretory protein 94 (PSP94) in metastatic hormone-refractory prostate cancer

Hawkins, R. E., Daigneault, L., Cowan, R., Griffiths, R., Panchal, C., Armstrong, A., Fenemore, J., Irvine, A., Sereda, K. & Dulude, H., Sept 2005, In: Clinical Prostate Cancer. 4, 2, p. 91-99 8 p.

Research output: Contribution to journal › Article › peer-review

Toward personalized immunotherapy for non-hodgkin lymphoma targeting the idiotypic immunoglobulin

Hawkins, R., Armstrong, A. C., Cheadle, E. J. & Hawkins, R. E., 2005, In: BioDrugs. 19, 5, p. 289-297 8 p.

Research output: Contribution to journal › Article › peer-review

2004

Adoptive transfer of anti-idiotypic T cells cure mice of disseminated B cell lymphoma

Armstrong, A. C., Dermime, S., Mulryan, K., Stern, P. L., Bhattacharyya, T. & Hawkins, R. E., May 2004, In: Journal of Immunotherapy. 27, 3, p. 227-231 4 p.

Research output: Contribution to journal › Article › peer-review

Antibody-directed enzyme-prodrug therapy.

Pedley, R., Sharma, S., Hawkins, RE. & Chester, K., 2004, In: Methods Mol Med. 90

Research output: Contribution to journal › Article › peer-review

Transduction of Passaged Human Articular Chondrocytes with Adenoviral, Retroviral, and Lentiviral Vectors and the Effects of Enhanced Expression of SOX9

Ying, L., Tew, S. R., Russell, A. M., Gonzalez, K. R., Hardingham, T. E. & Hawkins, R. E., Mar 2004, In: Tissue Engineering. 10, 3-4, p. 575-584 9 p.

Research output: Contribution to journal › Article › peer-review

Vaccine and antibody-directed T cell tumour immunotherapy

Dermime, S., Gilham, D. E., Shaw, D. M., Davidson, E. J., Meziane, E. K., Armstrong, A., Hawkins, R. E. & Stern, P. L., 6 Jul 2004, In: Biochimica et Biophysica Acta - Reviews on Cancer. 1704, 1, p. 11-35 24 p.

Research output: Contribution to journal › Article › peer-review

2003

Gene therapy of patient-derived T lymphocytes to target and eradicate colorectal hepatic metastases

Hawkins, R., Sheen, A. J., Irlam, J., Kirillova, N., Guest, R. D., Sherlock, D. J., Hawkins, R. E. & Gilham, D. E., 1 Jun 2003, In: Diseases of the Colon and Rectum. 46, 6, p. 793-804 11 p.

Research output: Contribution to journal › Article › peer-review

T lymphocytes isolated from patients with advanced colorectal cancer are suitable for gene immunotherapy approaches

Sheen, A. J., Sherlock, D. J., Irlam, J., Hawkins, R. E. & Gilham, D. E., 7 Apr 2003, In: British Journal of Cancer. 88, 7, p. 1119-1127 8 p.

Research output: Contribution to journal › Article › peer-review

2002

Cimetidine in colorectal cancer - Are the effects immunological or adhesion-mediated?

Eaton, D. & Hawkins, R. E., 21 Jan 2002, In: British Journal of Cancer. 86, 2, p. 159-160 1 p.

Research output: Contribution to journal › Article › peer-review

Immunization with a recombinant adenovirus encoding a lymphoma idiotype: Induction of tumor-protective immunity and identification of an idiotype-specific T cell epitope

Armstrong, A. C., Dermime, S., Allinson, C. G., Bhattacharyya, T., Mulryan, K., Gonzalez, K. R., Stern, P. L. & Hawkins, R. E., 15 Apr 2002, In: Journal of Immunology. 168, 8, p. 3983-3991 8 p.

Research output: Contribution to journal › Article › peer-review

Marimastat as Maintenance Therapy for Patients with Advanced Gastric and Gastro-oesophageal Cancer: A Randomised Trial.

Hawkins, R., 2002, In: British Journal of Cancer.. (86)12

Research output: Contribution to journal › Article › peer-review

Primary polyclonal human T lymphocytes targeted to carcino-embryonic antigens and neural cell adhesion molecule tumor antigens by CD3zeta-based chimeric immune receptors.

Gilham, DE., O'Neil, A., Hughes, C., Guest, R., Kirillova, N., Lehane, M. & Hawkins, RE., 2002, In: J Immunother. 25( 2)

Research output: Contribution to journal › Article › peer-review

Retroviral transduction of human peripheral blood lymphocytes with bcl-x(L) promotes in vitro lymphocyte survival in pro-apoptotic conditions.

Eaton, D., Gilham, DE., O'Neill, A. & Hawkins, RE., 2002, In: Gene Therapy. (9)8

Research output: Contribution to journal › Article › peer-review

2000

Selective targeting of gene transfer to vascular endothelial cells using peptide isolated by phage display.

Hawkins, RE. & Nicklin, SA. W. SJ. W. SJ. B. AH., 2000, In: Circulation. 102(2):

Research output: Contribution to journal › Article › peer-review

1999

Carcinoembryonic antigen (CEA)-specific T-cell activation in colon carcinoma induced by anti-CD3 x anti-CEA bispecific diabodies and B7 x anti- CEA bispecific fusion proteins

Holliger, P., Manzke, O., Span, M., Hawkins, R., Fleischmann, B., Qinghua, L., Wolf, J., Diehl, V., Cochet, O., Winter, G. & Bohlen, H., 15 Jun 1999, In: Cancer Research. 59, 12, p. 2909-2916 7 p.

Research output: Contribution to journal › Article › peer-review

Robert Hawkins, MA MB BS PhD FRCP

Research output

Search results