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Biography

1984-1987 BSc (hons) Chemistry Manchester
1987-1988 Research Chemist at ICI Pharmaceuticals (now AstraZeneca).
1988-1989 MSc Organic Synthesis (supervisor, Prof. J.K. Sutherland) Manchester
1989-1991 PhD Organic Synthesis (supervisor, Prof. J.K. Sutherland) Manchester
1991-1995 Postdoctoral research under the guidance of Prof. Sir J.E. Baldwin Oxford
1996-1999 University Lecturer in Organic Chemistry Reading
1999-present University Lecturer in Organic and Biological Chemistry Manchester

Research interests

Our research interests fall into three main areas:
EXPLOITATION OF CHEMICAL PREDISPOSITION IN NATURAL PRODUCT SYNTHESIS
We are tackling the syntheses of the sponge derived fatty acid derivatives, manzamenones A and G and the unusual cytotoxic alkaloid, madangamine A, using approaches founded on the principles of predisposed chemistry.
NOVEL ANTI-BACTERIAL AND ANTI-FUNGAL AGENTS
We are preparing a range of analogues of intermediates on the shikimic acid, tryptophan and histidine biosynthetic pathways, which have been selected as likely competitive inhibitors of various enzymes on the respective pathways. On completion of the synthetic investigations, in vitro studies of the inhibition of purified enzymes by these unnatural substrates will be carried out.
NATURALLY OCCURRING ANTI-TUMOUR AGENTS
We are interested in preparing a number of naturally occurring anti-tumour agents. In particular, we are investigating the synthesis of varacin, an unusual benzopentathiepin which is 100 times more active than fluorouracil against human colon cancer.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 14 - Life Below Water

Education/Academic qualification

Doctor of Philosophy, The University of Manchester

Award Date: 26 Nov 1991

Areas of expertise

  • QD Chemistry
  • Q Science (General)

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