Personal profile
Research interests
My research interests involve identifying how cellular calcium buffers modulate the systolic calcium transient. For the heart to contract calcium increases inside the cardiac myocyte. However, most of the calcium that is added to the cell to produce this contraction is bound to buffers. Currently there is some uncertainty as to the role played by these calcium buffers in regulating the contraction of the cardiac myocytes. By measuring the calcium concentration inside these cells, I am currently examining which components of the cell act as calcium buffers and am investigating their role in shaping the changes of calcium inside the cardiac myocytes.
Memberships of committees and professional bodies
Physiological Society
Biophysical Society
Qualifications
- 2003: BSc (Hons) First Class. University of Manchester, UK. Pharmacology with Industrial Experience (undertaken at Boehringer-Ingelheim, Biberach, Germany)
- 2007: PhD. University of Manchester, UK. "Channels and Transporters in Human Stem Cells"
Research Beacons, Institutes and Platforms
- Christabel Pankhurst Institute
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Research output
- 2 Article
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Temporal Development of Autonomic Dysfunction in Heart Failure: Effects of Age in an Ovine Rapid-pacing Model
Horn, M. A., Bode, E. F., Borland, S. J., Kirkwood, G. J., Briston, S. J., Richards, M. A., Dibb, K. M. & Trafford, A. W., 26 Dec 2015, In: Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 71, 12, p. 1544-1552 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytes
Briston, S., Dibb, K. M., Solaro, R. J., Eisner, D. A. & Trafford, A., 1 Nov 2014, In: Cardiovascular research. 104, 2, p. 347-354 8 p.Research output: Contribution to journal › Article › peer-review
Open Access