Research output per year
Research output per year
Personal profile
Overview
Sam joined the university as a Senior Lecturer in Medicinal Chemistry in November 2016. Prior to this he worked at the University of Birmingham from 2013 and at AstraZeneca from 2005-2013. During this time he has been accountable for chemistry strategy and delivery for all phases of discovery projects through externalised pre-portfolio collaborations, HTS, Lead Generation, Lead Optimisation to Pre-clinical development. His work at AstraZeneca led to the development of a targeted anti-cancer agent AZD9291, that was approved by the FDA in November 2015 and is now used internationally under the name osimertinib/Tagrisso. Along with his colleagues Sam has been recognised for this work through the 2017 RSC Malcolm Campbell Award and the 2018 ACS Heroes of Chemistry award (see link above).
The Butterworth group work on applying synthetic and biological chemistry to study and solve biological problems of relevance to human health and disease. All projects are conducted in collaboration with biomedical researchers and clinicians, allowing testing of compounds in the most relevant biological models.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Areas of expertise
- QD Chemistry
- RM Therapeutics. Pharmacology
Fingerprint
Dive into the research topics where Sam Butterworth is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Diarylamine Synthesis via Desulfinylative Smiles Rearrangement
Sephton, T., Large, J. M., Butterworth, S. & Greaney, M. F., 30 Jan 2022, In: Organic Letters.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Downloads (Pure) -
Sustained drug release from smart nanoparticles in cancer therapy: a comprehensive review
Bai, X., Zara L Smith, Z. L., Wang, Y., Butterworth, S. & Tirella, A., 22 Sep 2022, (Accepted/In press) In: Micromachines.Research output: Contribution to journal › Review article › peer-review
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Circadian control of hepatitis B virus replication
Zhuang, X., Forde, D., Tsukuda, S., D’Arienzo, V., Mailly, L., Harris, J. M., Wing, P. A. C., Borrmann, H., Schilling, M., Magri, A., Rubio, C. O., Maidstone, R. J., Iqbal, M., Garzon, M., Minisini, R., Pirisi, M., Butterworth, S., Balfe, P., Ray, D. W., Watashi, K., & 2 others, 12 Mar 2021, In: Nature Communications. 12, 1, 1658.Research output: Contribution to journal › Article › peer-review
Open Access -
Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity
Cundy, N. J., Hare, R. K., Tang, T., Leach, A. G., Jowitt, T. A., Qureshi, O., Gordon, J., Barnes, N. M., Brady, C. A., Raven, E. L., Grainger, R. S. & Butterworth, S., 13 Sep 2021, In: RSC Chemical Biology.Research output: Contribution to journal › Article › peer-review
Open Access -
Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model
Butterworth, S. & Garzon Sanz, M., 20 May 2020, In: Journal of Medicinal Chemistry. 63, 13, p. 6784-6801 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Downloads (Pure)
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High resolution cyclic ion mobility HDX mass spectrometry of protein dynamics and function
Politis, A., Baldock, C., Barran, P., Butterworth, S., Dixon, N., Francavilla, C., Hollywood, K., Hubbard, S., Leys, D., Lowe, M., Pavitt, G., Swift, J., Tabernero, L. & Woodman, P.
31/10/22 → 31/03/23
Project: Research
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Developing a Novel Class of ERK5 Inhibitors for the Treatment of Triple-Negative Breast Cancer.
Finegan, K., Butterworth, S., Houston, J. & Williams, K.
1/09/18 → 31/10/21
Project: Research
Datasets
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CCDC 698983: Experimental Crystal Structure Determination
Kaiser, J. (Contributor), Van Esseveldt, B. C. J. (Contributor), Segers, M. J. A. (Contributor), Van Delft, F. L. (Contributor), Smits, J. M. M. (Contributor), Butterworth, S. (Contributor) & Rutjes, F. P. J. T. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2009
DOI: 10.5517/ccrgbvc, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccrgbvc&sid=DataCite
Dataset
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CCDC 698982: Experimental Crystal Structure Determination
Kaiser, J. (Contributor), Van Esseveldt, B. C. J. (Contributor), Segers, M. J. A. (Contributor), Van Delft, F. L. (Contributor), Smits, J. M. M. (Contributor), Butterworth, S. (Contributor) & Rutjes, F. P. J. T. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2009
DOI: 10.5517/ccrgbtb, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccrgbtb&sid=DataCite
Dataset
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CCDC 698984: Experimental Crystal Structure Determination
Kaiser, J. (Contributor), Van Esseveldt, B. C. J. (Contributor), Segers, M. J. A. (Contributor), Van Delft, F. L. (Contributor), Smits, J. M. M. (Contributor), Butterworth, S. (Contributor) & Rutjes, F. P. J. T. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2009
DOI: 10.5517/ccrgbwd, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccrgbwd&sid=DataCite
Dataset
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CCDC 730223: Experimental Crystal Structure Determination
Donohoe, T. J. (Contributor), Wheelhouse, K. M. P. (Contributor), Lindsay-Scott, P. J. (Contributor), Churchill, G. H. (Contributor), Connolly, M. J. (Contributor), Butterworth, S. (Contributor) & Glossop, P. A. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2010
DOI: 10.5517/ccshvlp, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccshvlp&sid=DataCite
Dataset
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CCDC 614405: Experimental Crystal Structure Determination
Donohoe, T. J. (Contributor), Harris, R. M. (Contributor), Butterworth, S. (Contributor), Burrows, J. N. (Contributor), Cowley, A. (Contributor) & Parker, J. S. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2006
DOI: 10.5517/ccnmbj3, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccnmbj3&sid=DataCite
Dataset