Research output per year
Research output per year
- 100 - 133 out of 133 results
Search results
-
2010
Direct analysis of donor-acceptor distance and relationship to isotope effects and the force constant for barrier compression in enzymatic H-tunneling reactions
Pudney, C., Johannissen, L., Sutcliffe, M. J., Hay, S. & Scrutton, N. S., 18 Aug 2010, In: Journal of the American Chemical Society. 132, 32, p. 11329-11335 6 p.Research output: Contribution to journal › Article › peer-review
-
Probing active site geometry using high pressure and secondary isotope effects in an enzyme-catalysed 'deep' H-tunnelling reaction
Hay, S., Pudney, C. R., Sutcliffe, M. J. & Scrutton, N. S., Jul 2010, In: Journal of Physical Organic Chemistry. 23, 7, p. 696-701 5 p.Research output: Contribution to journal › Article › peer-review
-
2009
Are the catalytic properties of enzymes from piezophilic organisms pressure adapted?
Hay, S., Evans, R. M., Levy, C., Loveridge, E. J., Wang, X., Leys, D., Allemann, R. K. & Scrutton, N. S., 21 Sept 2009, In: ChemBioChem: a European journal of chemical biology . 10, 14, p. 2348-2353 5 p.Research output: Contribution to journal › Article › peer-review
-
Barrier compression enhances an enzymatic hydrogen-transfer reaction
Hay, S., Pudney, C. R., McGrory, T. A., Pang, J., Sutcliffe, M. J. & Scrutton, N. S., 9 Feb 2009, In: Angewandte Chemie - International Edition. 48, 8, p. 1452-1454 2 p.Research output: Contribution to journal › Article › peer-review
-
Bipartite recognition and conformational sampling mechanisms for hydride transfer from nicotinamide coenzyme to FMN in pentaerythritol tetranitrate reductase
Pudney, C. R., Hay, S. & Scrutton, N. S., Sept 2009, In: FEBS Journal. 276, 17, p. 4780-4789 9 p.Research output: Contribution to journal › Article › peer-review
-
Demonstration of proton-coupled electron transfer in the copper-containing nitrite reductases
Brenner, S., Heyes, D. J., Hay, S., Hough, M. A., Eady, R. R., Hasnain, S. S. & Scrutton, N. S., 18 Sept 2009, In: Journal of Biological Chemistry. 284, 38, p. 25973-25983 10 p.Research output: Contribution to journal › Article › peer-review
-
Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction
Pudney, C., Hay, S., Levy, C., Pang, J., Sutcliffe, M. J., Leys, D. & Scrutton, N. S., 2 Dec 2009, In: Journal of the American Chemical Society. 131, 47, p. 17072-17073 1 p.Research output: Contribution to journal › Article › peer-review
-
Parallel pathways and free-energy landscapes for enzymatic hydride transfer probed by hydrostatic pressure
Pudney, C. R., McGrory, T., Lafite, P., Pang, J., Hay, S., Leys, D., Sutcliffe, M. J. & Scrutton, N. S., 25 May 2009, In: ChemBioChem: a European journal of chemical biology . 10, 8, p. 1379-1384 5 p.Research output: Contribution to journal › Article › peer-review
-
Probing coupled motions in enzymatic hydrogen tunnelling reactions: beyond temperature-dependence studies of kinetic isotope effects
Hay, S., Sutcliffe, M. & Scrutton, N., 2009, Quantum tunnelling in enzyme-catalysed reactions. London: Royal Society of Chemistry, p. 199-218 20 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
-
Structural and mechanistic aspects of flavoproteins: Probes of hydrogen tunnelling
Hay, S., Pudney, C. R. & Scrutton, N. S., Aug 2009, In: FEBS Journal. 276, 15, p. 3930-3941 11 p.Research output: Contribution to journal › Article › peer-review
-
2008
Are environmentally coupled enzymatic hydrogen tunneling reactions influenced by changes in solution viscosity?
Hay, S., Pudney, C. R., Sutcliffe, M. J. & Scrutton, N. S., 2008, In: Angewandte Chemie - International Edition. 47, 3, p. 537-540 3 p.Research output: Contribution to journal › Article › peer-review
-
Atomistic insight into the origin of the temperature-dependence of kinetic isotope effects and H-tunnelling in enzyme systems is revealed through combined experimental studies and biomolecular simulation
Hay, S., Pudney, C., Hothi, P., Johannissen, L. O., Masgrau, L., Pang, J., Leys, D., Sutcliffe, M. J. & Scrutton, N. S., Feb 2008, In: Biochemical Society Transactions. 36, 1, p. 16-21 5 p.Research output: Contribution to journal › Article › peer-review
-
Correction of pre-steady-state KIEs for isotopic impurities and the consequences of kinetic isotope fractionation
Hay, S., Pudney, C. R., Hothi, P. & Scrutton, N. S., 18 Dec 2008, In: Journal of Physical Chemistry A. 112, 50, p. 13109-13115 6 p.Research output: Contribution to journal › Article › peer-review
-
Deep tunneling dominates the biologically important hydride transfer reaction from NADH to FMN in morphinone reductase
Pang, J., Hay, S., Scrutton, N. S. & Sutcliffe, M. J., 4 Jun 2008, In: Journal of the American Chemical Society. 130, 22, p. 7092-7097 5 p.Research output: Contribution to journal › Article › peer-review
-
Driving force analysis of proton tunnelling across a reactivity series for an enzyme-substrate complex.
Hothi, P., Hay, S., Roujeinikova, A., Sutcliffe, M. J., Lee, M., Leys, D., Cullis, P. M. & Scrutton, N. S., 24 Nov 2008, In: ChemBioChem: a European journal of chemical biology . 9, 17, p. 2839-2845 6 p.Research output: Contribution to journal › Article › peer-review
-
H-transfers in Photosystem II: What can we learn from recent lessons in the enzyme community?
Hay, S. & Scrutton, N. S., Oct 2008, In: Photosynthesis Research. 98, 1-3, p. 169-177 8 p.Research output: Contribution to journal › Article › peer-review
-
Incorporation of hydrostatic pressure into models of hydrogen tunneling highlights a role for pressure-modulated promoting vibrations
Hay, S. & Scrutton, N. S., 16 Sept 2008, In: Biochemistry. 47, 37, p. 9880-9887 7 p.Research output: Contribution to journal › Article › peer-review
-
Inter-flavin electron transfer in cytochrome P450 reductase - Effects of solvent and pH identify hidden complexity in mechanism
Brenner, S., Hay, S., Munro, A. W. & Scrutton, N. S., Sept 2008, In: FEBS Journal. 275, 18, p. 4540-4557 17 p.Research output: Contribution to journal › Article › peer-review
-
Making a single-chain four-helix bundle for redox chemistry studies
Westerlund, K., Moran, S. D., Privett, H. K., Hay, S., Jarvet, J., Gibney, B. R. & Tommos, C., Nov 2008, In: Protein Engineering, Design and Selection. 21, 11, p. 645-652 7 p.Research output: Contribution to journal › Article › peer-review
-
Promoting motions facilitate nuclear tunneling in flavoprotein enzymes
Hay, S., Pudney, C., Pang, J., Leys, D., Sutcliffe, M. & Scrutton, N., 2008, Flavins and Flavoproteins 2008. Prensas Universitarias de Zaragoza, p. 415-426Research output: Chapter in Book/Report/Conference proceeding › Chapter
-
Secondary kinetic isotope effects as probes of environmentally-coupled enzymatic hydrogen tunneling reactions
Hay, S., Pang, J., Monaghan, P. J., Wang, X., Evans, R. M., Sutcliffe, M. J., Allemann, R. K. & Scrutton, N. S., 4 Aug 2008, In: ChemPhysChem. 9, 11, p. 1536-1539 3 p.Research output: Contribution to journal › Article › peer-review
-
Solvent as a probe of active site motion and chemistry during the hydrogen tunnelling reaction in morphinone reductase
Hay, S., Pudney, C. R., Sutcliffe, M. J. & Scrutton, N. S., 15 Sept 2008, In: ChemPhysChem. 9, 13, p. 1875-1881 6 p.Research output: Contribution to journal › Article › peer-review
-
2007
Conformational dynamics of the cytochrome P450 BM3/N-palmitoylglycine complex: The proposed "proximal-distal" transition probed by temperature-jump spectroscopy
Brenner, S., Hay, S., Girvan, H. M., Munro, A. W. & Scrutton, N. S., 12 Jul 2007, In: Journal of Physical Chemistry B. 111, 27, p. 7879-7886 7 p.Research output: Contribution to journal › Article › peer-review
-
DNA binding suppresses human AIF-M2 activity and provides a connection between redox chemistry, reactive oxygen species, and apoptosis
Gong, M., Hay, S., Marshall, K. R., Munro, A. W. & Scrutton, N. S., 12 Oct 2007, In: Journal of Biological Chemistry. 282, 41, p. 30331-30340 9 p.Research output: Contribution to journal › Article › peer-review
-
Magnetic field effect studies indicate reduced geminate recombination of the radical pair in substrate-bound adenosylcobalamin-dependent ethanolamine ammonia lyase
Jones, A. R., Hay, S., Woodward, J. R. & Scrutton, N. S., 19 Dec 2007, In: Journal of the American Chemical Society. 129, 50, p. 15718-15727 9 p.Research output: Contribution to journal › Article › peer-review
-
Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms
Pudney, C. R., Hay, S., Pang, J., Costello, C., Leys, D., Sutcliffe, M. J. & Scrutton, N. S., 14 Nov 2007, In: Journal of the American Chemical Society. 129, 45, p. 13949-13956 7 p.Research output: Contribution to journal › Article › peer-review
-
Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects
Hay, S., Sutcliffe, M. J. & Scrutton, N. S., 9 Jan 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 2, p. 507-512 5 p.Research output: Contribution to journal › Article › peer-review
-
Proton tunneling in aromatic amine dehydrogenase is driven by a short-range sub-picosecond promoting vibration: Consistency of simulation and theory with experiment
Johannissen, L. O., Hay, S., Scrutton, N. S. & Sutcliffe, M. J., 15 Mar 2007, In: Journal of Physical Chemistry B. 111, 10, p. 2631-2638 7 p.Research output: Contribution to journal › Article › peer-review
-
Redox characteristics of a de novo quinone protein
Hay, S., Westerlund, K. & Tommos, C., 5 Apr 2007, In: Journal of Physical Chemistry B. 111, 13, p. 3488-3495 7 p.Research output: Contribution to journal › Article › peer-review
-
2006
α-secondary isotope effects as probes of "tunneling-ready" configurations in enzymatic H-tunneling: Insight from environmentally coupled tunneling models
Pudney, C. R., Hay, S., Sutcliffe, M. J. & Scrutton, N. S., 1 Nov 2006, In: Journal of the American Chemical Society. 128, 43, p. 14053-14058 5 p.Research output: Contribution to journal › Article › peer-review
-
2005
Conversion of the Escherichia coli cytochrome b562 to an archetype cytochrome b: A mutant with bis-histidine ligation of heme iron
Hay, S. & Wydrzynski, T., 11 Jan 2005, In: Biochemistry. 44, 1, p. 431-439 8 p.Research output: Contribution to journal › Article › peer-review
-
Moving a phenol hydroxyl group from the surface to the interior of a protein: Effects on the phenol potential and pKA
Hay, S., Westerlund, K. & Tommos, C., 6 Sept 2005, In: Biochemistry. 44, 35, p. 11891-11902 11 p.Research output: Contribution to journal › Article › peer-review
-
2004
Protein engineering of cytochrome b562 for quinone binding and light-induced electron transfer
Hay, S., Wallace, B. B., Smith, T. A., Ghiggino, K. P. & Wydrzynski, T., 21 Dec 2004, In: Proceedings of the National Academy of Sciences of the United States of America. 101, 51, p. 17675-17680 5 p.Research output: Contribution to journal › Article › peer-review