Research output per year
Research output per year
Personal profile
Biography
Samrina studied Chemistry followed by MSc Cheminformatics at the University of Manchester, and then joined Inpharmatica Ltd, a former informatics-driven drug discovery company. Some of her work was integrated into what is now known as ChEMBLdb. She then completed a Ph.D. pioneering the application of systems biology methods to analyse Dupuytren biology, followed by postdoctoral research applying these methods to investigate liver disease (functional genomic data from patient-derived iPSCs), chronic myeloid leukemia, and urothelial cancer and later secured a fellowship sponsored by Unilever to investigate the metabolome of the human scalp. Samrina then joined Evotec SE bringing her expertise in systems biology, functional genomics data integration, and computational methods to complement and enhance Evotec’s drug discovery services. In 2019, Samrina joined the Medicines Discovery Catapult where she provides bioinformatics support to the UK life science and drug discovery SME community and supports a portfolio of immuno-oncology projects with a leading medical research charity. She is also leading an informatics collaboration on motor neurone disease with the charitable trust and is engaged in projects on healthy ageing and neuropathic pain. Samrina is an honorary senior research fellow at the University of Manchester and a member of the American Dupuytren’s Foundation research committee.
Research interests
Application of informatics, modelling and systems biology tools and techniques to help unravel the complexity of human physiology and address challenges in a range of clinical conditions, disease and also gerontology. Projects span across several medical areas i.e. connective tissue disorders, plastic & reconstructive surgery research, hepatology, neurology (motor neurone disease and multiple sclerosis), neuropathic pain and also healthy ageing.
- Medical systems biology
- Biomarker and drug discovery
- Clinical metabolomics
- Cancer and stem cell research
- Informatics, machine learning, multivariate data analysis, biostatistics.
Qualifications
- PhD Systems Biology, University of Manchester, 2011
- MSc Cheminformatics, UMIST/University of Manchester, 2005
- MChem Hons. Chemistry, University of Manchester, 2004
Memberships of committees and professional bodies
- Royal Society of Chemistry, 2006-
- Biochemical Society (a FEBS constituent society), 2007-
- Duypuytren Research Committee, 2017-
- British Society for Antimicrobial Chemotherapy, 2019-
- Data Science Foundation, 2020-
- British Society for Research on Ageing, 2022-
Impact
Awards/Grants/Prizes/News
- In the news: Dupuytrens' Disease Maps
- Global Challenges Research Fund Institutional Sponsorship (£salary)(Prof. A Masters, total value £5,400), Feb 2017
- In the news: Statification of the severity of Non-Alcoholic Fatty Liver Disease
- Unilever Sponsorship awarded (£salary) (with Prof. HV Westerhoff, total value £55,000), Dec 2014
- Unilever Sponsorship awarded (£salary) (with Prof. HV Westerhoff, total value £180,000), Nov 2013
- Best poster award sponsored by Biocrates Life Sciences at the 2nd Metabolomics & Systems Biology conference, Chicago, USA, Apr 2013
- Scoping Project funds extended (with Prof. HV Westerhoff), Unilever UK & Ireland, (£4,085), Mar 2013
- Scoping Project funds (with Prof. HV Westerhoff), Unilever UK & Ireland, (£16,387), Oct 2012
- Invitrogen award to present at University of California, Irvine, USA ($1000), May 2010
My collaborations
Please see Samrina's publications for indications of her extensive international collaboration network.
Other
Not for profit Dupuytrens Research Foundation
Industry Unilever UK, Evotec UK
Opportunities
- Collaboration opportunities with Medicines Discovery Catapult
- Call for proposals - Psychiatry consortium https://md.catapult.org.uk/syndicates/psychiatry-consortium/
Contact:
For academic/research collaborations please contact: Samrina.Rehman@manchester.ac.uk
For industrial, commercial and translational research interest please contact: Samrina.Rehman@md.catapult.org.uk
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, A Systems approach to understand Dupuytren's disease
1 Jan 2007 → 10 Jun 2011
Award Date: 13 Dec 2011
External positions
Scientist, Infrastructure for Systems Biology Europe
Bioinformatics Data Scientist, Medicines Discovery Catapult Ltd
Research Beacons, Institutes and Platforms
- Digital Futures
- Cancer
- Institute for Data Science and AI
Fingerprint
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Investigating the potential of GalR2 as a drug target for neuropathic pain
Rich, K., Rehman, S., Jerman, J. & Wilkinson, G., 17 Dec 2022, (Accepted/In press) In: NEUROPEPTIDES.Research output: Contribution to journal › Review article › peer-review
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Maps for when the living gets tough: Maneuvering through a hostile energy
Mondeel, T. D. G. A., Rehman, S., Zhang, Y., Verma, M., Duerre, P., Barberis, M. & Westerhoff, H. V., 2016, In: IFAC-PapersOnLine. 49, 26, p. 364-370Research output: Contribution to journal › Article › peer-review
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Maps for when the living gets tough: Maneuvering through a hostile energy landscape
Mondeel, T. D. G. A., Rehman, S., Zhang, Y., Verma, M., Dürre, P., Barberis, M. & Westerhoff, H. V., 1 Sep 2016, (Submitted) 6th IFAC Conference on Foundations of Systems Biology in Engineering.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes
Wruck, W., Kashofer, K., Rehman, S., Daskalaki, A., Berg, D., Gralka, E., Jozefczuk, J., Drews, K., Pandey, V., Regenbrecht, C., Wierling, C., Turano, P., Korf, U., Zatloukal, K., Lehrach, H., Westerhoff, H. V. & Adjaye, J., 8 Dec 2015, In: Scientific Data. 2, p. 150068Research output: Contribution to journal › Article › peer-review
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SupraBiology 2014: Promoting UK-China collaboration on Systems Biology and High Performance Computing
Murabito, E., Colombo, R., Wu, C., Verma, M., Rehman, S., Snoep, J., Peng, S-L., Guan, N., Liao, X. & Westerhoff, H. V., 23 Mar 2015, In: Quantitative Biology. 3, 1, p. 46-53 8 p.Research output: Contribution to journal › Article › peer-review
Thesis
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A Systems Approach to Understanding Dupuytren's Disease
Author: Rehman, S., 31 Dec 2011Supervisor: Bayat, A. (Supervisor), Goodacre, R. (Supervisor), Rattray, M. (Supervisor), Day, P. (Supervisor) & Westerhoff, H. (Supervisor)
Student thesis: Phd
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