Personal profile
Overview
I have been interested in the fundamental questions behind clinical conditions from the beginning of my medical training. I completed a PhD in gene therapy in 2011 whilst at medical school through the MB PhD program at UCL. In my postgraduate training I became fascinated with disorders of the respiratory system and how the immune system can influence pathogenesis and clinical course. I have used NIHR funded posts to develop a core theme of respiratory immunology that I have applied to a broad range of respiratory conditions, most notably lung cancer and the recent COVID-19 pandemic.
Biography
Following an intercalated BSc in Immunology, I joined the MB PhD program at UCL in 2008. This led to a PhD in gene therapy, where I worked on how retroviral vectors dysregulate neighbouring gene expression. I also developed a new production system for lentiviral vectors that is scalable, enabling sufficient quantities of vector for widespread application. I graduated from UCL medical school in 2013 and joined the academic foundation program in Cambridge. I started a Respiratory Academic Clinical Fellowship in London in 2015 and relocated to the North West in 2017. I am now an Academic Clinical Lecturer and specialist registrar in Respiratory Medicine
Further information
Education/Academic qualification
Bachelor of Medicine and Bachelor of Surgery, University College London (UCL)
Award Date: 15 Jul 2013
Doctor of Philosophy, Lentiviral Vectors for Gene Therapy, University College London (UCL)
Award Date: 28 Mar 2012
Bachelor of Science, Immunology and Cell Pathology, University College London (UCL)
Award Date: 1 Aug 2007
External positions
Honorary Respiratory Registrar, Hope Hospital Salford Royal NHS Foundation Trust
8 Aug 2019 → 7 Aug 2020
Areas of expertise
- R Medicine (General)
- Respiratory Medicine
Research Beacons, Institutes and Platforms
- Cancer
- Lydia Becker Institute
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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The role of the VWF/ADAMTS13 axis in the thromboinflammatory response in ischaemic stroke after SARS-CoV2 infection
Luka, N., South, K., Jones, R., Unsworth, A. J., Coutts, G., Mosneag, I.-E., Younas, M., Bradley, A., Wong, S. Y., Collins, E., Quigley, C., Knight, S., Mccoll, B. W., McCulloch, L., Grainger, J., Smith, C. & Allan, S., 20 Feb 2025, (E-pub ahead of print) In: Behavioural and Brain Functions. e70348.Research output: Contribution to journal › Article › peer-review
Open Access -
Trial protocol and update for the DREM study
Knight, S., Blake, A., Eyre, H., Kirkham, S., Hussell, T., Cartmell, S., Finegan, K., Hodgetts, R. & Evison, M., Feb 2025, In: Lung Cancer. 200, 2 p., 108180.Research output: Contribution to journal › Meeting Abstract › peer-review
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Autoantibodies Neutralizing Type III Interferons Are Uncommon in Patients with Severe Coronavirus Disease 2019 Pneumonia
Vanker, M., Särekannu, K., Fekkar, A., Jørgensen, S. E., Haljasmägi, L., Kallaste, A., Kisand, K., Lember, M., Peterson, P., Menon, M., Hussell, T., Knight, S., Moore-Stanley, J., Bastard, P., Zhang, S.-Y., Mogensen, T. H., Philippot, Q., Zhang, Q., Puel, A. & Casanova, J.-L. & 1 others, , 15 Sept 2023, In: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 43, 9, p. 379-393 15 p.Research output: Contribution to journal › Article › peer-review
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Monocyte migration profiles define disease severity in acute COVID-19 and unique features of long COVID
CIRCO, Scott, N. A., Pearmain, L., Knight, S. B., Brand, O., Morgan, D. J., Jagger, C., Harbach, S., Khan, S., Shuwa, H. A., Franklin, M., Kästele, V., Williams, T., Prise, I., McClure, F. A., Hackney, P., Smith, L., Menon, M., Konkel, J. E. & Lawless, C. & 18 others, , 11 May 2023, (E-pub ahead of print) In: The European respiratory journal. 61, 5, 20 p., 2202226.Research output: Contribution to journal › Article › peer-review
Open Access -
Integrated miRNA/cytokine/chemokine profiling reveals severity-associated step changes and principal correlates of fatality in COVID-19
CIRCO Collaborative Group, 21 Jan 2022, In: iScience. 25, 1, p. 103672 103672.Research output: Contribution to journal › Article › peer-review
Open Access
Prizes
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Cordwainer's prize for best MB PhD Thesis
Knight, S. (Recipient), 2012
Prize: Prize (including medals and awards)
Activities
- 4 Membership of professional association
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European Respiratory Society (ERS) (External organisation)
Knight, S. (Academic expert member)
30 Jun 2018 → 30 Jun 2020Activity: Membership › Membership of professional association › Research
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Royal College of Physicians (External organisation)
Knight, S. (Academic expert member)
11 May 2018 → 1 Oct 2020Activity: Membership › Membership of professional association › Research
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The British Thoracic Society (External organisation)
Knight, S. (Academic expert member)
1 Aug 2015 → 30 Jun 2020Activity: Membership › Membership of professional association › Research
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General Medical Council (External organisation)
Knight, S. (Academic expert member)
15 Jul 2013 → 31 Jul 2020Activity: Membership › Membership of professional association › Research