Research output per year
Research output per year
Personal profile
Biography
2015-Present
Bioinformatician, The University of Manchester, Division of Cardiovascular Sciences
Contributing to the analysis of large-scale genetic experiments involving whole-exome and whole-genome sequencing, RNA-sequencing and microarray analyses in cardiovascular disease.
2012-2015
Clinical Bioinformatician, The Manchester Centre for Genomic Medicine
Developing and implementing bioinformatics pipelines for the analysis of NGS data in a clinical setting to ISO accredited standards.
2011-2012
Clinical Bioinformatician, The National Genetic Reference Laboratory
A role supporting clinical genetics laboratories in the UK. Involvement in projects that evaluate computational resources as well as integrating large-scale genomic data for use in diagnostic genetic labs.
2008-2011
Research Associate, The University of Manchester
“Identifying the determinants of specificity in protein interactions”
A computational biology research project in collaboration with lab scientists to assess the specificity of protein interactions in yeast.
Qualifications
2004-2008 - PhD “The Evolution of Protein Structure and Function”
The University of Manchester
2002-2003 - MSc Bioinformatics
The University of Manchester
1999-2002 - BSc (Hons), Biology
The University of Manchester
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
MGCM - Clinical bioinformatician, Central Manchester University Hospitals NHS Foundation Trust
1 Nov 2012 → 30 Nov 2015
NGRL - Clinical bioinformatician, Central Manchester University Hospitals NHS Foundation Trust
1 Jul 2011 → 1 Nov 2012
Research Beacons, Institutes and Platforms
- Digital Futures
Fingerprint
Dive into the research topics where Simon Williams is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks
Choy, M.-K., Javierre, B. M., Williams, S., Baross, S., Liu, Y., Wingett, S. W., Akbarov, A., Wallace, C., Freire-Pritchett, P., Rugg-Gunn, P. J., Spivakov, M., Fraser, P. & Keavney, B., 28 Jun 2018, In: Nature Communications.Research output: Contribution to journal › Article › peer-review
Open Access1 Downloads (Pure) -
Whole Exome Sequencing Reveals the Major Genetic Contributors to Nonsyndromic Tetralogy of Fallot
Page, D. J., Miossec, M. J., Williams, S. G., Monaghan, R. M., Fotiou, E., Cordell, H. J., Sutcliffe, L., Topf, A., Bourgey, M., Bourque, G., Eveleigh, R., Dunwoodie, S. L., Winlaw, D. S., Bhattacharya, S., Breckpot, J., Devriendt, K., Gewillig, M., Brook, J. D., Setchfield, K. J. & Bu'Lock, F. A. & 14 others, , 15 Feb 2019, In: Circulation research. 124, 4, p. 553-563 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile58 Downloads (Pure) -
Clinical risk associated with COVID-19 among 86000 patients with congenital heart disease
Williams, S. G., Frain, S., Guo, H., Carr, M. J., Ashcroft, D. M. & Keavney, B. D., 14 Dec 2023, In: Open Heart. 10, 2, e002415.Research output: Contribution to journal › Article › peer-review
Open Access -
Bi-allelic mutation of CTNNB1 causes a severe form of syndromic microphthalmia, persistent foetal vasculature and vitreoretinal dysplasia
Taylor, R. L., Soriano, C. S., Williams, S., Dzulova, D., Ashworth, J., Hall, G., Gale, T., Lloyd, I. C., Inglehearn, C. F., Toomes, C., Douzgou, S. & Black, G., 4 Mar 2022, In: Orphanet Journal of Rare Diseases. 17, 110.Research output: Contribution to journal › Article › peer-review
Open Access -
BS13 Genome-wide association study coupled with promoter interactomic data identifies neuroplastin (NPTN) as a potential novel gene regulating heart rate
Choy, M.-K., Liu, Y., Williams, S., Eales, J. & Keavney, B., Jun 2022.Research output: Contribution to conference › Abstract
Datasets
-
Binding interface change and cryptic variation in the evolution of protein-protein interactions
Ames, R. (Contributor), Talavera, D. (Contributor), Williams, S. (Contributor), Robertson, D. (Contributor) & Lovell, S. (Contributor), figshare , 18 Feb 2016
DOI: 10.6084/m9.figshare.c.3618035.v1, https://figshare.com/collections/Binding_interface_change_and_cryptic_variation_in_the_evolution_of_protein-protein_interactions/3618035/1
Dataset