Research output per year
Research output per year
3.20 Core Technology Facility
BHF Accelerator Research Fellow at the University of Manchester, Division of Cardiovascular Sciences
Dr Sophie Saxton obtained her Bachelor's degree in Pharmacology and Master of Research degree in Cardiovascular Science at the University of Manchester. She completed her PhD in 2017 in Cardiovascular Medicine, entitled "The sympathetic nervous system in perivascular adipose tissue". Dr Saxton has recently established her own laboratory as a British Heart Foundation Accelerator Fellow. She has continued her research in the functions of perivascular adipose tissue in modulating vascular tone, and adipose tissue dysfunction in obesity, leading to hypertension and diabetes. As an early career researcher (ECR), Dr Saxton is committed to the development of other ECRs and promotes opportunites through her work on the British Society for Cardiovascular Research Committee, and as an Executive Editor at the Journal of Hypertension. In addition she has a keen interest in social responsibility, in particular sustainable research, and her lab has been awarded Gold LEAF accreditation.
Sept 2014 - March 2017: PhD in Cardiovascular Medicine
Sept 2013 - Sept 2014: MRes in Cardiovascular Science
Sept 2009 - July 2013: BSc Pharmacology with Honours
Executive Editor at the Journal of Hypertension July 2021 to date
Society memberships:
British Society for Cardiovascular Research (committee member Jan 2020-Dec 2024)
British Microcirculation and Vascular Biology Society
Physiological Society
International Society of Hypertension
European Society for Cardiology
Perivascular adipose tissue (PVAT) surrounds the majority of blood vessels and is a highly metabolically active tissue. There is an increasing body of evidence to suggest that PVAT releases vasoactive factors which are vital in modulating vascular tone, however the mechanisms remain undefined. In obesity, PVAT becomes chronically inflammaed and dysfunctional, which may contribute to the development of hypertension and type-II diabetes. PVAT contains a highly diverse and plastic immune cell population, and targetting these immune cells in obesity may present novel therapeutic targets for intervention in obesity-related vascular diseases.
Wire Myography
Animal work - small mammals: blood pressure, exercise, surgery, high fat feeding.
Immunohistochemistry
ELISAs
Western Blotting
qPCR
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Placement student, University of Nevada School of Medicine
1 Aug 2011 → 1 Aug 2012
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Editorial › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Review article › peer-review
Saxton, S. (Recipient), 10 Sept 2018
Prize: Prize (including medals and awards)
Saxton, S. (Recipient), 26 Mar 2015
Prize: Prize (including medals and awards)
Saxton, S. (Recipient), 21 Apr 2017
Prize: Prize (including medals and awards)
Saxton, S. (Recipient), 9 Jul 2016
Prize: Prize (including medals and awards)
Saxton, S. (Editor)
Activity: Publication peer-review and editorial work › Editorial work › Research
Saxton, S. (Academic expert member)
Activity: Membership › Membership of committee › Research
Saxton, S. (Member)
Activity: Membership › Membership of professional association › Research
Saxton, S. (Co-Organiser)
Activity: Participating in or organising event(s) › Organising a conference, workshop, exhibition, performance, inquiry, course etc › Research
Student thesis: Phd