Senior Lecturer / Honorary Consultant Paediatric Oncologist, Division of Cancer Sciences.   Department of Paediatric and Adolescent Oncology of the University of Manchester at Royal Manchester Children’s and Christie Hospitals.

Stefan works as a Honorary Consultant Paediatric Oncologist at the Royal Manchester Children’s Hospital, and the Young Oncology Unit/Palatine Treatment Centre at the Chrisite NHS Foundation Trust. He leads the multidisciplinary care for children with Fanconi anaemia, Bloom syndrome and other Chromosomal Instability Syndromes.

Fanconi anaemia (FA), Bloom syndrome (BS) and other Chromosomal Instability syndromes (CIS) are inherited diseases with congenital and developmental abnormalities and extreme cancer predisposition. These conditions result from defects in fundamental DNA damage response pathways with an important role in development, haematopoiesis and cancer prevention. Our research is focused on malignant transformation associated with CIS, and functional aspects of the these pathways in sporadic cancers. Studying FA-derived AML cell lines we have identified amplification and overexpression of the EVI1 oncogene as a key event  associated with FA-characteristic gains in the chromosomal region 3q26q29 and leukaemic transformation. EVI1 is an oncogenic transcriptional regulator with a critical role in self renewal, with  chromatin remodeling properties, which we are exploring in the context of the FA defect.

Our FA-derived AML cell lines derived from the AML associated with bi-allelic disruption of the FANCD1/BRCA2 gene maintain the FA characteristic cross linker hypersensitivity. We explore the characteristics of the DNA damage response using systems biology approaches in order to identify regulatory events that might be therapeutically accessible.

Academic Lead - European Studies, Manchester Medical School

Firm Lead Year 4  (Paediatrics / Paediatic Oncology)

PhD and MD supervisor

MPH and MRes supervision

Academic Advisor

APEP and PEP supervisor

Dr Meyer's Paediatic Oncology Clinic at RMCH can be booked via MedLea

Dr Stefan Meyer works experimentally with Dr Christine Schmidt in the Genome Stability Lab on fundamental and translational questions relating to the DNA damage response with a focus on paediatric and syndrome associated cancers

Mr Joseph Hallet PhD Student (with Dr C Schmidt)

Mr Hazim AlHazmi PhD Student (with Dr C Schmidt)