Stefan Meyer

2024

Small molecule inhibition of CBX4/7 hypersensitises homologous recombination-impaired cancer to radiation by compromising CtIP-mediated DNA end resection

Osborne, H., Foster, B., Al-Hazmi, H., Meyer, S., Larrosa, I. & Schmidt, C., 6 Jun 2024, In: Cancers.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Convergent somatic evolution commences in utero in a germline ribosomopathy

Machado, H. E., Øbro, N. F., Williams, N., Tan, S., Boukerrou, A. Z., Davies, M., Belmonte, M., Mitchell, E., Baxter, E. J., Mende, N., Clay, A., Ancliff, P., Köglmeier, J., Killick, S. B., Kulasekararaj, A., Meyer, S., Laurenti, E., Campbell, P. J., Kent, D. G. & Nangalia, J. & 1 others, Warren, A. J., 22 Aug 2023, In: Nature Communications. 14, 1

Research output: Contribution to journal › Article › peer-review

Open Access

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2022

Embryonal sarcoma of the liver in a girl with Cockayne Syndrome

Thorbinson, C., Penn, A., Nicola, P., Hardcastle, C. L., Waller, S., Ramsden, S., Coorens, T. H. H., Tang, V., Cheesman, E., Douzgou, S. & Meyer, S., 1 Mar 2022, In: Clinical Genetics.

Research output: Contribution to journal › Letter › peer-review

Open Access

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EVI1 protein interaction dynamics: targetable for therapeutic intervention?

Paredes, R., Doleschall, N., Connors, K., Geary, B. & Meyer, S., 1 Mar 2022, In: Experimental Hematology. 107, p. 1-8 8 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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108 Downloads (Pure)

RecQ Helicase Somatic Alterations in Cancer

Thakkar, M. K., Lee, J., Meyer, S. & Chang, V. Y., 15 Jun 2022, In: Frontiers in Molecular Biosciences. 9

Research output: Contribution to journal › Review article › peer-review

Open Access

2021

Excellent overall and chronic graft-versus-host-disease-free event-free survival in Fanconi anaemia patients undergoing matched related- and unrelated-donor bone marrow transplantation using alemtuzumab–Flu–Cy: the UK experience

UK Paediatric BMT group, 1 Apr 2021, (Accepted/In press) In: British Jounal Haematology.

Research output: Contribution to journal › Article › peer-review

Fanconi Anaemia, Childhood Cancer and the BRCA Genes

Woodward, E. R. & Meyer, S., 27 Sept 2021, In: Genes. 12, 10, p. 1520

Research output: Contribution to journal › Review article › peer-review

Open Access

High penetrance of myeloid neoplasia with diverse clinical and cytogenetic features in three siblings with a familial GATA2 deficiency

Ellingford, J., Telford, N., Urquhart, J., Will, A. M., Bonney, D., Adams, B., Dixon, R., Kerr, B., Black, G., Wynn, R. F. & Meyer, S., 6 Apr 2021, (Accepted/In press) In: Cancer Genetics.

Research output: Contribution to journal › Article › peer-review

2020

EVI1 oncoprotein expression and CtBP1 association oscillate through the cell cycle

Paredes, R., Schneider, M., Pearson, S., Teng, H.-Y., Kelly, J., Pierce, A., Somervaille, T., Whetton, A. & Meyer, S., 5 Sept 2020, (Accepted/In press) In: Molecular Biology Reports.

Research output: Contribution to journal › Article › peer-review

EVI1-phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal

Paredes, R., Kelly, J., Geary, B., Almarzouq, B., Schneider, M., Pearson, S., Narayanan, P., Williamson, A., Lovell, S., Wiseman, D., Chadwick, J., Jones, N. J., Kustikova, O., Schambach, A., Garner, T., Amaral, F., Pierce, A., Stevens, A., Somervaille, T. & Whetton, A. & 1 others, Meyer, S., 20 Oct 2020, In: Cell Death and Disease. 11, 878 (2020).

Research output: Contribution to journal › Article › peer-review

Open Access

Genomic profiling of acute myeloid leukaemia associated with ataxia telangiectasia identifies a complex karyotype with wildtype TP53 and mutant KRAS, G3BP1 and IL7R

Goldgraben, M. A., Fewings, E., Larionov, A., Scarth, J., Redman, J., Telford, N., Arkwright, P., Bonney, D., Wilks, D., Kulkarni, S., Taylor, A. M. R., Tischkowitz, M. D. & Meyer, S., 30 Mar 2020, (Accepted/In press) In: Pediatric Blood and Cancer.

Research output: Contribution to journal › Article › peer-review

Infantile fibrosarcoma with TPM3-NTRK1 fusion in a boy with Bloom Syndrome

Huson, S., Staab, T., Pereira, M., Ward, H., Paredes, R., Evans, D. G., Baumhoer, D., O'Sullivan, J., Cheesman, E., Schindler, D. & Meyer, S., 11 Nov 2020, (Accepted/In press) In: Familial Cancer.

Research output: Contribution to journal › Article › peer-review

2019

Chromosome instability syndromes

Taylor, A. M. R., Rothblum-oviatt, C., Ellis, N. A., Hickson, I. D., Meyer, S., Crawford, T. O., Smogorzewska, A., Pietrucha, B., Weemaes, C. & Stewart, G. S., 19 Sept 2019, (E-pub ahead of print) In: Nature Reviews. Disease Primers. 5, 1

Research output: Contribution to journal › Article › peer-review

Open Access

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Proteomic analysis of an induced pluripotent stem cell model reveals strategies to treat Juvenile Myelomonocytic Leukaemia

Pearson, S., Guo, B., Pierce, A., Azadbakht, N., Brazzatti, J. A., Patassini, S., Mulero-navarro, S., Meyer, S., Flotho, C., Gelb, B. D. & Whetton, A. D., 2019, In: Journal of Proteome Research.

Research output: Contribution to journal › Article › peer-review

2018

EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association

Paredes, R., Schneider, M., Stevens, F., White, D., Williamson , A. J. K., Muter, J., Pearson, S., Kelly, J., Connors, K., Wiseman, D., Chadwick, J., Loffler, H., Teng, H. Y., Lovell, S., Unwin, R., Van De Vrugt, H. J., Smith, H., Kustikova, O., Schambach, A. & Somervaille, T. & 3 others, Pierce, A., Whetton, A. & Meyer, S., 6 Sept 2018, In: Nucleic acids research. 46, 15, p. 7662-7674

Research output: Contribution to journal › Article › peer-review

Open Access

Fanconi anemia with sun-sensitivity caused by a Xeroderma pigmentosum-associated missense mutation in XPF

Popp, I., Punekar, M., Telford, N., Stivaros, S., Chandler, K., Minnis, M., Castleton, A., Higham, C., Hopewell, L., Evans, D. G., Raams, A., Theils, A. F., Meyer, S. & Schindler, D., 11 Jan 2018, In: BMC Medical Genetics.

Research output: Contribution to journal › Article › peer-review

Open Access

Patterns and frequency of renal abnormalities in Fanconi anaemia: implications for long-term management

Sathyanarayana, V., Lee, B., Wright, N. B., Santos, R., Bonney, D., Wynn, R., Patel, L., Chandler, K., Cheesman, E., Schindler, D., Webb, N. J. A. & Meyer, S., 12 Apr 2018, In: Pediatric Nephrology. 33, 9, p. 1547-1551 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Acquired cross linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption

Meyer, S., Stevens, F., Paredes, R., Schneider, M., Walker, M., Williamson, A., Gonzalez-Sanchez, M., Smetsers, S., Dalal, V., Teng, H.-Y., White, D., Taylor, S., Muter, J., Pierce, A., De Leonibus, C., Rockx, D. A., Rooimans, M., Spooncer, E., Stauffer, S. & Biswas, K. & 5 others, Godthelp, B., Dorsman, J., Clayton, P., Sharan, S. K. & Whetton, A., 2017, In: CELL DEATH & DISEASE. 8, e2875.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

Human TRIB2 oscillates during the cell cycle and promotes ubiquitination and degradation of CDC25C

Liang, K. L., Paredes, R., Carmody, R., Eyers, P. A., Meyer, S., McCarthy, T. V. & Keeshan, K., 2016, In: International Journal of Molecular Sciences. 17, 9, 1378.

Research output: Contribution to journal › Article › peer-review

Open Access

Network analysis and juvenile idiopathic arthritis (JIA): a new horizon for the understanding of disease pathogenesis and therapeutic target identification

Donn, R., De Leonibus, C., Meyer, S. & Stevens, A., 2016, In: Pediatric Rheumatology. 14, 40.

Research output: Contribution to journal › Article › peer-review

Open Access

2015

Central nervous system abnormalities in Fanconi anaemia: patterns and frequency on magnetic resonance imaging.

Stivaros, S., Alston, R., Wright, N. B., Chandler, K., Bonney, D., Wynn, R. F., Will, A. M., Punekar, M., Loughran, S., Kilday, J.-P., Schindler, D., Patel, L. & Meyer, S., 2015, In: The British journal of radiology. 88, 1056

Research output: Contribution to journal › Article › peer-review

Fanconi anaemia: genetics, molecular biology, and cancer - implications for clinical management in children and adults.

Schneider, M., Chandler, K., Tischkowitz, M. & Meyer, S., 1 Jul 2015, In: Clinical Genetics. 88, 1, p. 13-24 11 p.

Research output: Contribution to journal › Article › peer-review

2014

EVI1 expression in childhood acute lymphoblastic leukaemia is not restricted to MLL and BCR/ABL rearrangements and is influenced by age.

Stevens, A., Hanson, D., de Leonibus, C., Whatmore, A., Donn, R., White, D. J., Liu, J., van den Heuvel-Eibrink, M. M., Saha, V., Clayton, P. E. & Meyer, S., 2014, In: Blood cancer journal. 4

Research output: Contribution to journal › Article › peer-review

Fanconi anaemia, BRCA2 mutations and childhood cancer: a developmental perspective from clinical and epidemiological observations with implications for genetic counselling.

Meyer, S., Tischkowitz, M., Chandler, K., Gillespie, A., Birch, J. & Evans, D. G., 1 Feb 2014, In: Journal of Medical Genetics. 51, 2, p. 71-75 4 p.

Research output: Contribution to journal › Article › peer-review

Network analysis identifies protein clusters of functional importance in juvenile idiopathic arthritis

Stevens, A., Meyer, S., Hanson, D., Clayton, P. & Donn, R., 8 May 2014, In: Arthritis Research and Therapy. 16, 3, R109.

Research output: Contribution to journal › Article › peer-review

Pollicisation of the index finger in Fanconi anaemia: Appearances and functionality forty years after the intervention.

Stivaros, S. M., Punekar, M., Chandler, K., Rost, I., Schindler, D. & Meyer, S., 3 Jul 2014, In: British Journal of Haematology. 166, 6, p. 807

Research output: Contribution to journal › Article › peer-review

2013

Acute Myeloid Leukaemia after Treatment for Acute Lymphoblastic Leukaemia in Girl with Bloom Syndrome

Adams, M., Jenney, M., Lazarou, L., White, R., Birdsall, S., Staab, T., Schindler, D. & Meyer, S., Sept 2013, In: Journal of Genetic Syndromes & Gene Therapy .

Research output: Contribution to journal › Article › peer-review

Network analysis: A new approach to study endocrine disorders

Stevens, A., De Leonibus, C., Hanson, D., Dowsey, A. W., Whatmore, A., Meyer, S., Donn, R. P., Chatelain, P., Banerjee, I., Cosgrove, K., Clayton, P. E. & Dunne, M. J., 1 Oct 2013, In: Journal of molecular endocrinology. 52, 1, p. R79-R93

Research output: Contribution to journal › Article › peer-review

Pediatric perspective on pharmacogenomics

Stevens, A., De Leonibus, C., Hanson, D., Whatmore, A., Murray, P., Donn, R., Meyer, S., Chatelain, P. & Clayton, P., Nov 2013, In: Pharmacogenomics. 14, 15, p. 1889-1905 16 p.

Research output: Contribution to journal › Article › peer-review

Phosphorylation of the Leukemic Oncoprotein EVI1 on Serine 196 Modulates DNA Binding, Transcriptional Repression and Transforming Ability

White, D. J., Unwin, R. D., Bindels, E., Pierce, A., Teng, H. Y., Muter, J., Greystoke, B., Somerville, T. D., Griffiths, J., Lovell, S., Somervaille, T. C. P., Delwel, R., Whetton, A. D. & Meyer, S., 12 Jun 2013, In: PLoS ONE. 8, 6, e66510.

Research output: Contribution to journal › Article › peer-review

Transglutaminase 2 expression in acute myeloid leukemia: Association with adhesion molecule expression and leukemic blast motility

Pierce, A., Whetton, A. D., Meyer, S., Ravandi-Kashani, F., Borthakur, G., Coombes, K. R., Zhang, N. & Kornblau, S., Jul 2013, In: Proteomics. 13, 14, p. 2216-2224 8 p.

Research output: Contribution to journal › Article › peer-review

2012

A molecular, genetic, and diagnostic spotlight on fanconi anemia

Hays, L. E., Meyer, S. & Van De Vrugt, H. J., 2012, In: Anemia. 2012, 650730.

Research output: Contribution to journal › Editorial › peer-review

Chromosomal aberrations associated with clonal evolution and leukemic transformation in fanconi anemia: Clinical and biological implications

Meyer, S., Neitzel, H. & Tönnies, H., 2012, In: Anemia. 2012, 349837.

Research output: Contribution to journal › Article › peer-review

Epigenetic inactivation of TWIST2 in acute lymphoblastic leukemia modulates proliferation, cell survival and chemosensitivity

Thathia, S. H., Ferguson, S., Gautrey, H. E., van Otterdijk, S. D., Hili, M., Rand, V., Moorman, A. V., Meyer, S., Brown, R. & Strathdee, G., 1 Mar 2012, In: Haematologica. 97, 3, p. 371-378 7 p.

Research output: Contribution to journal › Article › peer-review

Excellent outcome of matched unrelated donor transplantation in paediatric aplastic anaemia: A United Kingdom Multicentre Retrospective Experience

Samarasinghe, S., Steward, C., Hiwarkar, P., Saif, M., Hough, R., Webb, D., Norton, A., Lawson, S., Qureshi, A., Connor, P., Carey, P., Skinner, R., Vora, A., Pelidis, M., Gibson, B., Stewart, G., Keogh, S., Goulden, N., Bonney, D. & Stubbs, M. & 5 others, Amrolia, P., Rao, K., Meyer, S., Wynn, R. & Veys, P., 28 Feb 2012, In: British Journal of Haematology.

Research output: Contribution to journal › Article › peer-review

Heterozygote FANCD2 mutations associated with childhood T Cell ALL and testicular seminoma

Smetsers, S., Muter, J., Bristow, C., Patel, L., Chandler, K., Bonney, D., Wynn, R. F., Whetton, A. D., Will, A. M., Rockx, D., Joenje, H., Strathdee, G., Shanks, J., Klopocki, E., Gille, J. J. P., Dorsman, J. & Meyer, S., Dec 2012, In: Familial Cancer. 11, 4, p. 661-665 4 p.

Research output: Contribution to journal › Article › peer-review

Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus

Anderson, B., Kasher, P. R., Mayer, J., Szynkiewicz, M., Jenkinson, E. M., Bhaskar, S. S., Urquhart, J. E., Daly, S. B., Dickerson, J. E., O'Sullivan, J., Leibundgut, E. O., Muter, J., Abdel-Salem, G. M. H., Babul-Hirji, R., Baxter, P., Berger, A., Bonafé, L., Brunstom-Hernandez, J. E., Buckard, J. A. & Chitayat, D. & 45 others, Chong, W. K., Cordelli, D. M., Ferreira, P., Fluss, J., Forrest, E. H., Franzoni, E., Garone, C., Hammans, S. R., Houge, G., Hughes, I., Jacquemont, S., Jeannet, P. Y., Jefferson, R. J., Kumar, R., Kutschke, G., Lundberg, S., Loureno, C. M., Mehta, R., Naidu, S., Nischal, K. K., Nunes, L., Ounap, K., Philippart, M., Prabhakar, P., Risen, S. R., Schiffmann, R., Soh, C., Stephenson, J. B. P., Stewart, H., Stone, J., Tolmie, J. L., Van Der Knaap, M. S., Vieira, J. P., Vilain, C. N., Wakeling, E. L., Wermenbol, V., Whitney, A., Lovell, S. C., Meyer, S., Livingston, J. H., Baerlocher, G. M., Black, G. C. M., Rice, G. I., Yanick, J. & Lourenço, C. M., Mar 2012, In: Nature Genetics. 44, 3, p. 338-342 4 p.

Research output: Contribution to journal › Article › peer-review

2011

Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1

Lugthart, S., Figueroa, M. E., Bindels, E., Skrabanek, L., Valk, P. J. M., Li, Y., Meyer, S., Erpelinck-Verschueren, C., Greally, J., Löwenberg, B., Melnick, A. & Delwel, R., 6 Jan 2011, In: Blood. 117, 1, p. 234-241 7 p.

Research output: Contribution to journal › Article › peer-review

Acomprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay

Biswas, K., Das, R., Alter, B. P., Kuznetsov, S. G., Stauffer, S., North, S. L., Burkett, S., Brody, L. C., Meyer, S., Byrd, R. A. & Sharan, S. K., 1 Sept 2011, In: Blood. 118, 9, p. 2430-2442 12 p.

Research output: Contribution to journal › Article › peer-review

Fanconi anemia (FA)-associated 3q gains in leukemic transformation consistently target EVI1, but do not affect low TERC expression in FA

Meyer, S., Bristow, C., Wappett, M., Pepper, S., Whetton, A. D., Hanenberg, H., Neitzel, H., Wlodarski, M. W., Ebell, W. & Tönnies, H., 2 Jun 2011, In: Blood. 117, 22, p. 6047-6050 3 p.

Research output: Contribution to journal › Article › peer-review

Interventions for preventing oral mucositis for patients with cancer receiving treatment

Worthington, H., Clarkson, J. E., Bryan, G., Furness, S., Glenny, A.-M., Littlewood, A., Mccabe, M., Meyer, S., Khalid, T. & Riley, P., 13 Apr 2011, In: Cochrane database of systematic reviews (Online). 2011, 4, p. 1-234 234 p., CD000978.

Research output: Contribution to journal › Article › peer-review

Open Access

2010

Interventions for preventing oral mucositis for patients with cancer receiving treatment.

Worthington, H. V., Clarkson, J. E., Bryan, G., Furness, S., Glenny, A. M., Littlewood, A., McCabe, M. G., Meyer, S. & Khalid, T., 2010, In: Cochrane database of systematic reviews (Online : Update Software). 12, 12, p. CD000978 CD000978.

Research output: Contribution to journal › Article › peer-review

Interventions for treating oral candidiasis for patients with cancer receiving treatment

Worthington, H., Clarkson, J. E., Khalid, T., Meyer, S. & Mccabe, M., 7 Jul 2010, In: Cochrane Database of Systematic Reviews. 7, p. 1-29 29 p., CD001972.

Research output: Contribution to journal › Article › peer-review

Open Access

Interventions for treating oral candidiasis for patients with cancer receiving treatment.

Worthington, H. V., Clarkson, J. E., Khalid, T., Meyer, S. & McCabe, M., 2010, In: Cochrane database of systematic reviews (Online : Update Software). 7, 7, p. CD001972

Research output: Contribution to journal › Article › peer-review

File

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Interventions for treating oral mucositis for patients with cancer receiving treatment

Clarkson, J. E., Worthington, H., Furness, S., Mccabe, M., Khalid, T. & Meyer, S., 4 Aug 2010, In: Cochrane database of systematic reviews (Online). 8, p. 1-70 70 p., CD001973.

Research output: Contribution to journal › Article › peer-review

Open Access

Interventions for treating oral mucositis for patients with cancer receiving treatment

Clarkson, J. E., Worthington, H. V., Furness, S., McCabe, M., Khalid, T. & Meyer, S., 2010, In: Cochrane Database of Systemic Reviews. 8, 8

Research output: Contribution to journal › Article › peer-review

File

272 Downloads (Pure)

2007

Amplification and translocation of 3q26 with overexpression of EVII in fanconi anemia-derived childhood acute myeloid leukemia with biallelic FANCDI/BRCA2 disruption

Meyer, S., Fergusson, W. D., Whetton, A. D., Moreira-Leite, F., Pepper, S. D., Miller, C., Saunders, E. K., White, D. J., Will, A. M., Eden, T., Ikeda, H., Ullmann, R., Tuerkmen, S., Gerlach, A., Klopocki, E. & Tönnies, H., Apr 2007, In: Genes Chromosomes and Cancer. 46, 4, p. 359-372 13 p.

Research output: Contribution to journal › Article › peer-review

Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis

Strathdee, G., Holyoake, T. L., Sim, A., Parker, A., Oscier, D. G., Melo, J. V., Meyer, S., Eden, T., Dickinson, A. M., Mountford, J. C., Jorgensen, H. G., Soutar, R. & Brown, R., 1 Sept 2007, In: Clinical Cancer Research. 13, 17, p. 5048-5055 7 p.

Research output: Contribution to journal › Article › peer-review

2006

Acquired chemosensitivity after insect bite in a boy with leukaemia [5]

Meyer, S., Eden, T., Brennan, B. M. D., Stevens, R. F., Makin, G., Wynn, R. F., Carr, T. F. & Will, A. M., Jul 2006, In: British Journal of Haematology. 134, 2, p. 244-245 1 p.

Research output: Contribution to journal › Article › peer-review

Dexamethasone protects against cisplatin-induced activation of the mitochondrial apoptotic pathway in human osteosarcoma cells

Meyer, S., Eden, T. & Kalirai, H., Aug 2006, In: Cancer Biology and Therapy. 5, 8, p. 915-920 5 p.

Research output: Contribution to journal › Article › peer-review

Stefan Meyer, MD PhD MRCPCH

Research output

Search results