Research output per year
Research output per year
Personal profile
Overview
Immunologist specialising in autoimmune diseases with a focus on translational science. My current work centres on investigating refractory rheumatoid arthritis (RA) at the single-cell level, employing ATAC and RNA sequencing on CD4+ T cells, along with a mouse model in which RA-associated SNPs affecting a gene involved in apoptosis and thymic negative selection have been deleted. This research aims to elucidate how genetic alterations in immune tolerance mechanisms contribute to RA, with the goal of identifying novel therapeutic targets to restore immune balance in treatment-resistant patients.
Currently collaborating with the University of Oxford to enhance understanding of osteoarthritis, with a focus on identifying key genetic variants that regulate gene expression in this most common form of arthritis in the UK.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Immunology, The University of Manchester
Award Date: 24 Nov 2021
Master of Science, Biology - 110/110 cum laude - Distinction , Universita di Napoli (University of Naples Federico II)
Award Date: 17 May 2016
Bachelor of Science, BSc in Biological Sciences - 110/110 cum laude - 1st class honours, Universita di Napoli (University of Naples Federico II)
Award Date: 13 Nov 2013
External positions
Visiting Co-Investigator, The University of Oxford
Keywords
- Immunology
- Inflammation
- Transcriptomics
- Translational Medicine
Fingerprint
Dive into the research topics where Stefano Rossi is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Functional Genomics in Psoriasis
Rossi, S., Richards, E. L., Orozco, G. & Eyre, S., 4 Jul 2024, In: International Journal of Molecular Sciences. 25, 13Research output: Contribution to journal › Review article › peer-review
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A subset of CD4+ effector memory T cells limit immunity to pulmonary viral infection and prevent tissue pathology via activation of latent TGFβ
McEntee, C., Houston, S., Finlay, C., Rossi, S., Liu, G., Shaw, T., Casulli, J., Fife, M., Smedley, C., Griffith, T., Pepper, M., Hussell, T., Hansbro, P., Schwartz, J.-M., Paidassi, H. & Travis, M., 2 Mar 2023, In: bioRxiv.Research output: Contribution to journal › Article
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Multi-omics analysis in primary T cells elucidates mechanisms behind disease associated genetic loci
Shi, C., Zhao, D., Rossi, S., Frantzeskos, A., Ding, J., Ferrazzano, C., Wynn, C., Hum, R., Richards, E., Gupta, M., Yap, C. F., Plant, D., Grencis, R., Martin, P., Adamson, A., Eyre, S., Bowes, J., Barton, A., Ho, P. & Rattray, M. & 1 others, , 1 Jan 2023, In: medRxiv. p. 2023.07.19.23292550Research output: Contribution to journal › Article › peer-review
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The HLA-DQ8 transgenic mouse: A model to study the immune and cytotoxic responses to wheat gliadin
Maurano, F., Rotondi Aufiero, V., Treppiccione, L., Rossi, S., Luongo, D., Mazzarella, G. & Rossi, M., 2023, In: Methods in Cell Biology. 179, p. 157-171 15 p.Research output: Contribution to journal › Article › peer-review
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Transamidated wheat gliadin induces differential antigen recognition in the small intestine of HLA/DQ8 transgenic mice
Treppiccione, L., Maurano, F., Rossi, S., Luongo, D. & Rossi, M., 30 Aug 2022, In: Food and Function. 13, 17, p. 8941-8950 10 p.Research output: Contribution to journal › Article › peer-review
Thesis
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Determining important novel mechanisms that regulate T-cell-mediated immune responses
Rossi, S. (Author), Travis, M. (Supervisor) & Schwartz, J.-M. (Supervisor), 1 Aug 2022Student thesis: Phd
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