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PhD funded by the NIHR Manchester Biomedical Research Centre

Biography

I carried out my medical undergraduate training at the University of Liverpool and graduated with MBChB (Commendation). During my undergraduate studies, I undertook an intercalated degree and was awarded an MRes in Clinical Sciences. After graduation, I was awarded an Academic Foundation Programme post at University Hospital Aintree in Liverpool, where I was able to continue my MRes epidemiological work on an early inflammatory arthritis cohort.

 

I moved to Manchester when I was awarded an NIHR Academic Clinical Fellowship in Rheumatology. During this fellowship, I trained in genetic epidemiology techniques and I carried out analysis on an early inflammatory arthritis cohort involving genetic associations with sub-components of disease activity and disability scores.

 

I was awarded an NIHR Manchester Biomedical Research Centre Clinical Research Fellowship to carry out my PhD, which involved the conception and implementation of a phase 0 clinical trial of patients with rheumatoid arthritis starting adalimumab and etanercept biosimilars, the collection and analysis of pharmacological data from the above trial, and analysis of large-scale proteomics and genetics data, including the use of machine learning techniques.

 

I was re-deployed to front-line NHS services during the initial stages of the COVID-19 pandemic. This led to a series of publications around the immunodulatory potential of cholecalciferol therapy in the setting of acute SARS-COV-2 infection.

 

I was awarded an NIHR Academic Clinical Lectureship following the completion of my PhD. I am particularly interested in clinical disease outcome measures in inflammatory arthritis, analysis of large-scale, multi-faceted molecular data, and early-phase clinical trials with particular reference to dosing alteration that has been informed by population pharmacokinetic modelling and simulation.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Doctor of Philosophy, Personalising dosing of biologic therapies in inflammatory arthritis to maximise cost-benefit, The University of Manchester

Award Date: 7 Apr 2022

Bachelor of Medicine and Bachelor of Surgery

Sep 2005Jul 2011

Master of Research, Clinical Sciences

Jul 2009Jul 2010

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