Stephen Hopkins

2018

SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke): A Randomized Controlled Phase 2 Trial

Smith, C. J., Hulme, S., Vail, A., Heal, C., Parry-Jones, A. R., Scarth, S., Hopkins, K., Hoadley, M., Allan, S. M., Rothwell, N. J., Hopkins, S. J. & Tyrrell, P. J., May 2018, In: Stroke. 49, 5, p. 1210-1216 7 p.

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2015

How Is Pneumonia Diagnosed in Clinical Stroke Research? A Systematic Review and Meta-Analysis

Kishore, A., Vail, A., Chamorro, A., Garau, J., Hopkins, S., Di Napoli, M., Kalra, L., Langhorne, P., Montaner, J., Roffe, C., Rudd, A. G., Tyrrell, P., van de Beek, D., Woodhead, M., Meisel, A. & Smith, CJ., 2015, In: Stroke. 46, 5, p. 1202-1209 7 p.

Research output: Contribution to journal › Article › peer-review

2014

C-reactive protein predicts hematoma growth in intracerebral hemorrhage

Napoli, M. D., Parry-Jones, A. R., Smith, C. J., Hopkins, S. J., Slevin, M., Masotti, L., Campi, V., Singh, P., Papa, F., Popa-Wagner, A., Tudorica, V. & Godoy, D. A., Jan 2014, In: Stroke. 45, 1, p. 59-65 6 p.

Research output: Contribution to journal › Article › peer-review

Peripheral inflammatory markers in amnestic mild cognitive impairment

Karim, S., Hopkins, S., Purandare, N., Crowther, J., Morris, J., Tyrrell, P. & Burns, A., 2014, In: International journal of geriatric psychiatry. 29, 3, p. 221-226 6 p.

Research output: Contribution to journal › Article › peer-review

The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial.

Singh, N., Hopkins, S. J., Hulme, S., Galea, J. P., Hoadley, M., Vail, A., Hutchinson, P. J., Grainger, S., Rothwell, N. J., King, A. T. & Tyrrell, P. J., 3 Jan 2014, In: Journal of Neuroinflammation. 11, 1, p. 2-8 7 p., 1.

Research output: Contribution to journal › Article › peer-review

2013

Overcoming matrix matching problems in multiplex cytokine assays

Hoadley, M. E. & Hopkins, S. J., 2013, In: Journal of immunological methods. 396, 1-2, p. 157-162 5 p.

Research output: Contribution to journal › Article › peer-review

2012

Cerebrospinal fluid and plasma cytokines after subarachnoid haemorrhage: CSF interleukin-6 may be an early marker of infection

Hopkins, S. J., McMahon, C. J., Singh, N., Galea, J., Hoadley, M., Scarth, S., Patel, H., Vail, A., Hulme, S., Rothwell, N. J., King, A. & Tyrrell, P. J., 23 Nov 2012, In: Journal of Neuroinflammation. 9, 255.

Research output: Contribution to journal › Article › peer-review

Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression

Smith, C. J., Emsley, H. C., Udeh, C. T., Vail, A., Hoadley, M. E., Rothwell, N. J., Tyrrell, P. J. & Hopkins, S. J., Jun 2012, In: Cytokine. 58, 3, p. 384-389 5 p.

Research output: Contribution to journal › Article › peer-review

Reconstituting National Institute for Biological Standards and Control (NIBSC) chemokines

Hoadley, M. E., Scarth, S. & Hopkins, S. J., May 2012, In: Cytokine. 58, 2, p. 162-164 2 p.

Research output: Contribution to journal › Article › peer-review

2011

Brain inflammation is induced by co-morbidities and risk factors for stroke

Drake, C., Boutin, H., Jones, M. S., Denes, A., McColl, B. W., Selvarajah, J. R., Hulme, S., Georgiou, R. F., Hinz, R., Gerhard, A., Vail, A., Prenant, C., Julyan, P., Maroy, R., Brown, G., Smigova, A., Herholz, K., Kassiou, M., Crossman, D., Francis, S., & 6 othersProctor, S. D., Russell, J. C., Hopkins, S. J., Tyrrell, P. J., Rothwell, N. J. & Allan, S. M., Aug 2011, In: Brain, Behavior, and Immunity. 25, 6, p. 1113-1122 9 p.

Research output: Contribution to journal › Article › peer-review

Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: Results of a dose-ranging study

Galea, J., Ogungbenro, K., Hulme, S., Greenhalgh, A., Aarons, L., Scarth, S., Hutchinson, P., Grainger, S., King, A., Hopkins, S. J., Rothwell, N. & Tyrrell, P., Feb 2011, In: Journal of Cerebral Blood Flow and Metabolism. 31, 2, p. 439-447 8 p.

Research output: Contribution to journal › Article › peer-review

The effect of disease activity on body composition and resting energy expenditure in patients with rheumatoid arthritis

Binymin, K., Herrick, A. L., Carlson, G. L. & Hopkins, S. J., 2011, In: Journal of Inflammation Research. 4, 1, p. 61-66 5 p.

Research output: Contribution to journal › Article › peer-review

The effect of disease activity on body composition and resting energy expenditure in patients with rheumatoid arthritis Journal:

Binymin, K., Herrick, AL., Carlson, G. L. & Hopkins, S. J., 2011, In: Journal of Inflammation Research. 4, 1, p. 61-66 6 p.

Research output: Contribution to journal › Article › peer-review

2010

Interleukin-1 receptor antagonist in animal models of stroke: a fair summing up?

Parry-Jones, A., Boutin, H., Denes, A., McColl, B., Hopkins, S., Allan, S. & Tyrrell, P., 14 Jul 2010, In: Journal of Stroke and Cerebrovascular Diseases. 19, 6, p. 512-3 2 p.

Research output: Contribution to journal › Article › peer-review

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Post-stroke immunodepression and infection: An emerging concept

Emsley, H. C. A. & Hopkins, S. J., 2010, In: Infectious Disorders - Drug Targets. 10, 2, p. 91-97 6 p.

Research output: Contribution to journal › Article › peer-review

2008

Acute ischaemic stroke and infection: recent and emerging concepts

Emsley, H. CA. & Hopkins, S. J., Apr 2008, In: The Lancet Neurology. 7, 4, p. 341-353 12 p.

Research output: Contribution to journal › Article › peer-review

Infection and brain-induced immunodepression after acute ischemic stroke [7]

Emsley, H. C. A., Smith, C. J. & Hopkins, S. J., Jan 2008, In: Stroke. 39, 1, p. e7

Research output: Contribution to journal › Article › peer-review

Inflammation in acute ischemic stroke and its relevance to stroke critical care

Emsley, H. C. A., Smith, C. J., Tyrrell, P. J. & Hopkins, S. J., Aug 2008, In: Neurocritical Care. 9, 1, p. 125-138 13 p.

Research output: Contribution to journal › Article › peer-review

Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations

Clark, S. R., McMahon, C. J., Gueorguieva, I., Rowland, M., Scarth, S., Georgiou, R., Tyrrell, P. J., Hopkins, S. J. & Rothwell, N. J., Feb 2008, In: Journal of Cerebral Blood Flow and Metabolism. 28, 2, p. 387-394 7 p.

Research output: Contribution to journal › Article › peer-review

Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage

Gueorguieva, I., Clark, S. R., McMahon, C. J., Scarth, S., Rothwell, N. J., Tyrell, P. J., Hopkins, S. J., Rowland, M. & Tyrrell, P., Mar 2008, In: British Journal of Clinical Pharmacology. 65, 3, p. 317-325 8 p.

Research output: Contribution to journal › Article › peer-review

2007

Central nervous system recognition of peripheral inflammation: A neural, hormonal collaboration

Hopkins, S. J., Apr 2007, In: Acta Biomedica de l'Ateneo Parmense. 78, 1, p. 231-247 16 p.

Research output: Contribution to journal › Article › peer-review

Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production

Emsley, H. C. A., Smith, C. J., Gavin, C. M., Georgiou, R. F., Vail, A., Barberan, E. M., Illingworth, K., Scarth, S., Wickramasinghe, V., Hoadley, M. E., Rothwell, N. J., Tyrrell, P. J. & Hopkins, S. J., 2007, In: BMC Neurology. 7, 5.

Research output: Contribution to journal › Article › peer-review

Inflammation in human brain injury: Intracerebral concentrations of IL-1α, IL-1β, and their endogenous inhibitor IL-1ra

Hutchinson, P. J., O'Connell, M. T., Rothwell, N. J., Hopkins, S. J., Nortje, J., Carpenter, K. L. H., Timofeev, I., Al-Rawi, P. G., Menon, D. K. & Pickard, J. D., Oct 2007, In: Journal of neurotrauma. 24, 10, p. 1545-1557 12 p.

Research output: Contribution to journal › Article › peer-review

2006

Comparison of 'real-time' and immunometric RT-PCR: RNA interference of reverse transcriptase-PCR

Hoadley, M. E. & Hopkins, S. J., 30 May 2006, In: Journal of immunological methods. 312, 1-2, p. 40-44 4 p.

Research output: Contribution to journal › Article › peer-review

Variability of bacterial translocation in the absence of intestinal mucosal damage following injury and the influence of interleukin-6

Gunji, H., Scarth, S., Carlson, G. L., Warhurst, G., Little, R. A. & Hopkins, S. J., 21 Feb 2006, In: Pathophysiology. 13, 1, p. 39-49 10 p.

Research output: Contribution to journal › Article › peer-review

Variability of the systemic acute phase response after ischemic stroke

Smith, C. J., Emsley, H. C. A., Vail, A., Georgiou, R. F., Rothwell, N. J., Tyrrell, P. J. & Hopkins, S. J., 21 Dec 2006, In: JOURNAL OF THE NEUROLOGICAL SCIENCES. 251, 1-2, p. 77-81 4 p.

Research output: Contribution to journal › Article › peer-review

2005

A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients

Emsley, H. C. A., Smith, C. J., Georgiou, R. F., Vail, A., Hopkins, S. J., Rothwell, N. J. & Tyrrell, P. J., Oct 2005, In: Journal of Neurology, Neurosurgery and Psychiatry. 76, 10, p. 1366-1372 6 p.

Research output: Contribution to journal › Article › peer-review

Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: A statement for health care professionals from the CRP pooling project members

Di Napoli, M., Schwaninger, M., Cappelli, R., Ceccarelli, E., Di Gianfilippo, G., Donati, C., Emsley, H. C. A., Forconi, S., Hopkins, S. J., Masotti, L., Muir, K. W., Paciucci, A., Papa, F., Roncacci, S., Sander, D., Sander, K., Smith, C. J., Stefanini, A. & Weber, D., Jun 2005, In: Stroke. 36, 6, p. 1316-1329 13 p.

Research output: Contribution to journal › Article › peer-review

2004

Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome

Smith, C. J., Emsley, H. C. A., Gavin, C. M., Georgiou, R. F., Vail, A., Barberan, E. M., del Zoppo, G. J., Hallenbeck, J. M., Rothwell, N. J., Hopkins, S. J., Tyrrell, P. J. & Tyrrell, P., 15 Jan 2004, In: BMC Neurology. 4, 2.

Research output: Contribution to journal › Article › peer-review

2003

An early and sustained peripheral inflammatory response in acute ischaemic stroke: Relationships with infection and atherosclerosis

Emsley, H. C. A., Smith, C. J., Gavin, C. M., Georgiou, R. F., Vail, A., Barberan, E. M., Hallenbeck, J. M., Del Zoppo, G. J., Rothwell, N. J., Tyrrell, P. J., Hopkins, S. J. & Tyrrell, P., Jun 2003, In: Journal of neuroimmunology. 139, 1-2, p. 93-101 8 p.

Research output: Contribution to journal › Article › peer-review

Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice

Turnbull, A. V., Prehar, S., Kennedy, A. R., Little, R. A. & Hopkins, S. J., 1 May 2003, In: Endocrinology. 144, 5, p. 1894-1906 12 p.

Research output: Contribution to journal › Article › peer-review

Simple, quantitative measurement of cytokine gene expression using an immunometric reverse transcriptase-polymerase chain reaction

Hoadley, M. E. & Hopkins, S. J., Nov 2003, In: Journal of immunological methods. 282, 1-2, p. 135-145 10 p.

Research output: Contribution to journal › Article › peer-review

The pathophysiological role of cytokines

Hopkins, S. J., 2003, In: Legal Medicine. 5, 1, p. S45-S57

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2002

Different photoperiods affect proliferation of lymphocytes but not expression of cellular, humoral, or innate immunity in hamsters

Zhou, S., Cagampang, F. R. A., Stirland, J. A., Loudon, A. S. I. & Hopkins, S. J., 1 Oct 2002, In: Journal of Biological Rhythms. 17, 5, p. 392-405 13 p.

Research output: Contribution to journal › Article › peer-review

Remember the null hypothesis

Hopkins, S. J. & Loudon, A. S. I., 1 Oct 2002, In: Journal of Biological Rhythms. 17, 5, p. 410-412 2 p.

Research output: Contribution to journal › Article › peer-review

2001

Circulating tumour necrosis factor-alpha and interferon-gamma are detectable during acute and convalescent parvovirus B19 infection and are associated with prolonged and chronic fatigue.

Kerr, J. R., Barah, F., Mattey, D. L., Laing, I., Hopkins, SJ., Hutchinson, IV. & Tyrell, D. A. J., Dec 2001, In: J Gen Virol. 82( Pt 12)

Research output: Contribution to journal › Article › peer-review

Role of endogenous interleukin-1 receptor antagonist in regulating fever induced by localised inflammation in the rat

Cartmell, T., Luheshi, G. N., Hopkins, S. J., Rothwell, N. J. & Poole, S., 15 Feb 2001, In: Journal of Physiology. 531, 1, p. 171-180 9 p.

Research output: Contribution to journal › Article › peer-review

2000

Deficiency of interleukin-2 or interleukin-6 reduces lymphocyte proliferation, but only interleukin-6 deficiency decreases the contact hypersensitivity response.

Hope, JC., Campbell, F. & Hopkins, SJ., 2000, In: Eur. J. Immunol.. 30

Research output: Contribution to journal › Article › peer-review

Interleukin (IL)-6 release and fever induced by a pre-formed pyrogenic factor (PFPF) derived from LPS-stimulated macrophages

Zampronio, A. R., Hoadley, M. E., Luheshi, G., Rothwell, N. J., Petto de Souza, G. E. & Hopkins, S. J., 2000, In: European cytokine network. 11, 4, p. 589-596 7 p.

Research output: Contribution to journal › Article › peer-review

1997

Involvement of cytokines in cachexia induced by T-cell leukaemia in the rat

Roe, S. Y., Cooper, A. L., Morris, I. D., Hopkins, S. J. & Rothwell, N. J., 1997, In: European cytokine network. 8, 1, p. 45-49 4 p.

Research output: Contribution to journal › Article › peer-review

Local cytokine induction by LPS in the rat air pouch and its relationship to the febrile response

Miller, A. J., Luheshi, G. N., Rothwell, N. J. & Hopkins, S. J., Mar 1997, In: AJP: Regulatory, Integrative and Comparative Physiology. 272, 3, p. R857-R861

Research output: Contribution to journal › Article › peer-review

1996

Antigen-induced unresponsiveness in contact sensitivity: Association of depressed T lymphocyte proliferative responses with decreased interleukin 6 secretion

Dearman, R. J., Hope, J. C., Hopkins, S. J. & Kimber, I., Apr 1996, In: Immunology letters. 50, 1-2, p. 29-34 5 p.

Research output: Contribution to journal › Article › peer-review

Interleukin-1 receptor antagonist inhibits endotoxin fever and systemic interleukin-6 induction in the rat

Luheshi, G., Miller, A. J., Brouwer, S., Dascombe, M. J., Rothwell, N. J. & Hopkins, S. J., 1996, In: AJP: Endocrinology and Metabolism. 270, 1, p. E91-E95

Research output: Contribution to journal › Article › peer-review

1995

Cytokines and the nervous system I: expression and recognition

Hopkins, S. J. & Rothwell, N. J., Feb 1995, In: Trends in neurosciences. 18, 2, p. 83-88 5 p.

Research output: Contribution to journal › Article › peer-review

Cytokines and the nervous system II: actions and mechanisms of action

Rothwell, N. J. & Hopkins, S. J., Mar 1995, In: Trends in neurosciences. 18, 3, p. 130-136 6 p.

Research output: Contribution to journal › Article › peer-review

Identification of dendritic cells as a major source of interleukin-6 in draining lymph nodes following skin sensitization of mice

Hope, J. C., Cumberbatch, M., Fielding, I., Dearman, R. J., Kimber, I. & Hopkins, S. J., 1995, In: Immunology. 86, 3, p. 441-447 6 p.

Research output: Contribution to journal › Article › peer-review

Migration of interleukin-6 producing Langerhans cells to draining lymph nodes following skin sensitization

Cumberbatch, M., Hope, J. C., Dearman, R. J., Hopkins, S. J. & Kimber, I., 1995, In: Advances in Experimental Medicine and Biology. 378, p. 531-533 2 p.

Research output: Contribution to journal › Article › peer-review

Multiple mechanisms mediate antipyretic action of glucocorticoids

Coelho, M. M., Luheshi, G., Hopkins, S. J., Pela, I. R. & Rothwell, N. J., 1995, In: AJP: Regulatory, Integrative and Comparative Physiology. 269, 3, p. R527-R535

Research output: Contribution to journal › Article › peer-review

1994

Interleukin-6 production by draining lymph node cells following primary contact sensitisation of mice: Relationship to the proliferative response

Hope, J. C., Dearman, R. J., Debicki, R. J., Kimber, I. & Hopkins, S. J., 1994, In: International archives of allergy and immunology. 103, 4, p. 378-383 5 p.

Research output: Contribution to journal › Article › peer-review

Mechanisms of activation of the pituitary-adrenal axis by tissue injury in the rat

Turnbull, A. V., Dow, R. C., Hopkins, S. J., White, A., Fink, G. & Rothwell, N. J., 1994, In: Psychoneuroendocrinology. 19, 2, p. 165-178 13 p.

Research output: Contribution to journal › Article › peer-review

Stephen Hopkins, PhD

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