Research output per year
Research output per year
Personal profile
Research interests
Membrane Protein Structural Biology
Up to 30% of the genome of any given organism codes for integral membrane proteins, and over 50% of pharmacological targets are membrane proteins. Recombinant expression technology and Biophysical measurements can therefore be exploited to address membrane protein structure and function, revealing information on important classes of proteins such as Ion Channels, ABC transporters and the Outer Membrane Proteins of pathogenic bacteria.
Current projects focus on:
- Ion channels.
- Scaffold proteins associated with excitable membranes.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Structural Biology
- Protein biochemistry
- Protein-protein interactions
- Biophysics
- X-ray & Neutron Crystallography
- Electron Microscopy
- X-ray & Neutron Scattering
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Research output
- 28 Article
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A Structural Bioinformatics-Guided Study of Adenosine Triphosphate-Binding Cassette (ABC) Transporters and Their Substrates
Younus, I., Ford, R. & Prince, S. M., 10 Jan 2025, In: Membranes. 15, 1, 20.Research output: Contribution to journal › Article › peer-review
Open Access -
Structure of ABCB1/P-Glycoprotein in the Presence of the CFTR Potentiator Ivacaftor
Barbieri, A., Thonghin, N., Shafi, T., Prince, S. M., Collins, R. & Ford, R., 25 Nov 2021, In: Membranes. 11, 12, 923.Research output: Contribution to journal › Article › peer-review
Open Access -
The dual PDZ domain from Postsynaptic density protein 95 forms a scaffold with peptide ligand
Rodzli, N., Lockhart, M., Levy, C. W., Chipperfield, J., Bird, L., Baldock, C. & Prince, S. M., 4 Aug 2020, In: Biophysical Journal. 119, 3, p. 667-689 23 p.Research output: Contribution to journal › Article › peer-review
Open Access -
How the dual PDZ domain from Postsynaptic density protein 95 clusters ion channels and receptors. Running title: Clustering by PDZ1-2 of PSD-95
Ahmad Rodzli, N., Lockhart-Cairns, M., Levy, C. W., Chipperfield, J., Bird, L., Baldock, C. & Prince, S. M., 2019, In: bioRxiv. p. 775726Research output: Contribution to journal › Article
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The Cryo-EM Structure of the CorA channel from Methanocaldococcus jannaschii in low magnesium conditions.
Cleverley, R. M., Kean, J., Shintre, C. A., Baldock, C., Derrick, J. P., Ford, R. C. & Prince, S. M., 1 Oct 2015, In: Biochimica et Biophysica Acta. Biomembranes. 1848, 10 Pt A, p. 2206-2215 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile97 Downloads (Pure)
Projects
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Structural Biology
Politis, A. (Researcher), Prince, S. (Researcher), Roseman, A. (Researcher), Warwicker, J. (Researcher) & Pliotas, C. (Researcher)
Project: Research