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Stephen Prince, BSc, PhD

Dr

 https://orcid.org/0000-0003-0929-0254

Personal profile

Research interests

Membrane Protein Structural Biology

Up to 30% of the genome of any given organism codes for integral membrane proteins, and over 50% of pharmacological targets are membrane proteins. Recombinant expression technology and Biophysical measurements can therefore be exploited to address membrane protein structure and function, revealing information on important classes of proteins such as Ion Channels, ABC transporters and the Outer Membrane Proteins of pathogenic bacteria.
  
Current projects focus on:
  • Ion channels.
  • Scaffold proteins associated with excitable membranes.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 15 - Life on Land

Keywords

  • Structural Biology
  • Protein biochemistry
  • Protein-protein interactions
  • Biophysics
  • X-ray & Neutron Crystallography
  • Electron Microscopy
  • X-ray & Neutron Scattering

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Collaborations and top research areas from the last five years

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  • A Structural Bioinformatics-Guided Study of Adenosine Triphosphate-Binding Cassette (ABC) Transporters and Their Substrates

    Younus, I., Ford, R. & Prince, S. M., 10 Jan 2025, In: Membranes. 15, 1, 20.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Coming Clean and Avoiding Bubble Trouble–Using Detergents Wisely in the Purification of Membrane Proteins for Cryo-EM Studies

    Chen, B., Harrison, P., Kargas, V., Pollock, N., Ford, R. C., Prince, S. M. & Collins, R. F., 12 Sept 2025, In: Biomolecules.

    Research output: Contribution to journal › Article › peer-review

  • First Measurement of η Meson Production in Neutrino Interactions on Argon with MicroBooNE

    Abratenko, P., Alterkait, O., Aldana, D. A., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, J., Basque, V., Rodrigues, O. B., Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A. & Bogart, B. & 167 others, Bolton, T., Book, J. Y., Camilleri, L., Cao, Y., Caratelli, D., Terrazas, I. C., Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Englezos, P., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Foreman, W., Fleming, B. T., Foppiani, N., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Imani, Z., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y.-J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J.-Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. M., Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mogan, A., Mohayai, T., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. M., Mulleriababu, S., Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H. B., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I. D., Pophale, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. R., Rosenberg, M., Ross-Lonergan, M., von Rohr, C. R., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., St John, J., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y.-T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J. & Zhang, C., 10 Apr 2024, In: Physical Review Letters. 132, 15, 7 p., 151801.

    Research output: Contribution to journal › Article › peer-review

  • Structure of ABCB1/P-Glycoprotein in the Presence of the CFTR Potentiator Ivacaftor

    Barbieri, A., Thonghin, N., Shafi, T., Prince, S. M., Collins, R. & Ford, R., 25 Nov 2021, In: Membranes. 11, 12, 923.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • The dual PDZ domain from Postsynaptic density protein 95 forms a scaffold with peptide ligand

    Rodzli, N., Lockhart, M., Levy, C. W., Chipperfield, J., Bird, L., Baldock, C. & Prince, S. M., 4 Aug 2020, In: Biophysical Journal. 119, 3, p. 667-689 23 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
View all 30 research outputs