Tanuj Puri

Dr.

    Personal profile

    Research interests

    • Toxicity prediction modeling using radiotherapy dose & genomics data in prostate cancer 
    • Quantitative [18F]NaF PET imaging in metastatic and metabolic bone diseases
    • Quantitative hypoxia imaging using [18F]FMISO in rectal cancer and [64Cu]CuATSM in head & neck cancer
    • Quantitative measurement of microparameters like (K-tr, Vp, Ve) in lung using DCE-MRI

    Overview

    Affiliations:

    • Faculty of Biology, Medicine and Health, School of Medical Sciences, Division of Cancer Sciences, Cancer Sciences

    Methodological knowledge

    • Developed methods to measure Ki in bones using a static 4-min or a dynamic 12-min [18F]NaF PET scans, which was previously possible only using a 60-min dynamic PET scan
    • Developed methods & software tools to measure Ki at the hip using 60-min dynamic [18F]NaF PET scans. Furthermore, provided evidence to suggest that it is the reduction in the blood flow that causes a reduction in bone metabolism at the hip compared to that at the lumbar spine
    • Developed a semi-population-based method to estimate accurate arterial input function using 2-3 venous blood samples only.
    • Developed a method to spatially align [64Cu]CuATSM PET images and histology samples of the standard block size (30x21mm)
    • Provided evidence to suggest that [18F]FMISO PET should be used to assess hypoxia in rectal cancer with extreme caution
    • Developed a software tool to measure changes in pulmonary vascular properties in a human model of acute lung injury using DCE-MRI
    • Devised image analysis methodology and analysed imaging data for 9 clinical studies 

    Supervision information

    Linking geometric uncertainties in rectum segmentation with severity of toxicity - 2: 4th year (final year) undergraduate project in the department of Physics and Astronomy in the first semester of the 2022-2023 academic year

    Author: Green, D., 2023

    Supervisor: Vasquez Osorio, E. (Main Supervisor), Mcwilliam, A. (Supervisor) & Puri, T. (Supervisor)

    Undergraduate thesis

     

    Linking geometric uncertainties in rectum segmentation with severity of toxicity - 1: 4th year (final year) undergraduate project in the department of Physics and Astronomy in the first semester of the 2022-2023 academic year.

    Author: Bouzaki, A., 2023

    Supervisor: Vasquez Osorio, E. (Main Supervisor), Mcwilliam, A. (Supervisor) & Puri, T. (Supervisor)

    Undergraduate thesis

    Other research

    Programming or coding using MATLAB, Lua, Python, R, Batch script, Bash script, PowerShell script and WorldMatch. 

    Education/Academic qualification

    Doctor of Philosophy, Quantitative Measurement of Regional Bone Metabolism at the Hip Using dynamic [18F]NaF PET Imaging (Jointly in collaboration with King's College London), University College Dublin

    20082011

    Award Date: 15 Jul 2012

    Master of Science, Communications, Control & Digital Signal Processing, University of Strathclyde

    20062007

    Award Date: 31 Oct 2007

    Research Beacons, Institutes and Platforms

    • Christabel Pankhurst Institute
    • Institute for Data Science and AI
    • Digital Futures
    • Manchester Cancer Research Centre

    Keywords

    • Dose Surface Mapping
    • Genomics
    • Radiotherapy
    • Toxicity
    • Bone Metabolism
    • Hypoxia
    • Cancer
    • DCE-MRI
    • Imaging
    • Pharmacokinetic
    • [18F]FMISO
    • [18F]NaF
    • [64Cu]CuATSM
    • [18F]FDG
    • Modeling
    • PET-CT
    • MATLAB
    • Lua
    • Python
    • R
    • WorldMatch
    • Bash
    • Batch
    • PowerShell

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