Personal profile

Research interests

In addition to supporting our perception of the visual environment, a significant portion of the retinal output targets elements of a so-called non-image forming (NIF) visual system. By acting to synchronise cellular circadian oscillators across the brain as well as driving much more rapid modulations in neural activity, ultimately this NIF system coordinates daily rhythms in almost every aspect of physiology and behaviour. As a consequence, unnatural patterns of light exposure (e.g. night-shift work), disrupt the ability of the NIF system to appropriately coordinate physiology and can lead to a range of detrimental effects on health. My lab aims to understand the functional organisation of the NIF visual system, with a long term goal of identifying how we can adjust the design of the visual environments in which we live to optimise health and well-being.

The key brain nuclei of the NIF visual system and well established and span regions of the hypothalamus, thalamus and pretectum. At the gross anatomical level there is abundant evidence of interconnections between these nuclei, implying that they interact to define NIF responses. However, the specific neural pathways through which the various cell-types in each region communicate visual information to one another and/or downstream targets are unknown. Our primary aims, then, are to reveal the network circuitry responsible for controlling specific NIF responses and their unique sensory characteristics. To this end we use an array of techniques including large scale electrophysiological recording, sophisticated visual stimuli, optogenetics, viral tracing and computational approaches to probe network function.

 

Overview

While we think of the eye as the origin of visual perception, it plays an equally important role in regulating many other body systems. Indeed, information about the amount of light reaching the eye is communicated to a number of brain regions involved in the control of sleep, arousal, metabolism and hormone secretion. Most notably, such information controls the timing of our ‘body-clock’, which in turn regulates rhythmic variations in almost all body processes from athletic ability to cognitive performance. My lab aims to understand how visual signals are communicated and processed within the brain to drive these subconscious changes in physiology and behaviour.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Beacons, Institutes and Platforms

  • Christabel Pankhurst Institute
  • Manchester Environmental Research Institute

Keywords

  • circadian biology
  • light
  • vision
  • electrophysiology

Fingerprint

Dive into the research topics where Timothy Brown is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or