Research output per year
Research output per year
Personal profile
Overview
My research focuses on understanding microbial competition systems and defence mechanisms, their evolution, and their impact on microbial ecology and human disease. Using modelling, microscopy, bioinformatics and lab-based evolution methods, I am characterising the emergence of new attack and defence mechanisms within microbial communities, and leveraging these to reshape the outcomes of competition. By understanding and targeting the competitive strategies of pathogenic bacteria, my work helps us to monitor, prevent and mitigate microbial infections.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Master of Chemistry, Stuctural, Mechanical and Thermodynamic Properties of DNA Pseudoknots, Oxford University
1 Oct 2008 → 31 Jul 2012
Award Date: 31 Jul 2012
Doctor of Philosophy, Influences of cell shape in microbial communities
External positions
Review board member, Microbiology Journal, Microbiology Society
1 Apr 2024 → …
Areas of expertise
- QA76 Computer software
- QH301 Biology
- QH426 Genetics
Research Beacons, Institutes and Platforms
- Biotechnology
Keywords
- Microbial Ecology
- Microbial Evolution
- Secretion Systems
- Computer Modelling
- Experimental Evolution
- Bacterial Toxins
- Antimicrobial resistance
- Biotechnology
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Multiplicity of type 6 secretion system toxins limits the evolution of resistance
Smith, W., Armstrong-Bond, E., Coyte, K., Knight, C., Basler, M. & Brockhurst, M., 9 Jan 2025, In: Proceedings of the National Academy of Sciences. 122, 2, e2416700122.Research output: Contribution to journal › Article › peer-review
Open Access -
Multiplicity of type 6 secretion system toxins limits the evolution of resistance
Smith, W. P. J., Armstrong-Bond, E., Coyte, K. Z., Knight, C. G., Basler, M. & Brockhurst, M. A., 14 Jan 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 2, e2416700122.Research output: Contribution to journal › Article › peer-review
Open Access -
Type VI secretion system activity at lethal antibiotic concentrations leads to overestimation of weapon potency
Smith, W. & Granato, E. T., 11 Mar 2025, bioRxiv.Research output: Preprint/Working paper › Preprint
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Multiplicity of Type 6 Secretion System toxins limits the evolution of resistance
Smith, W., Armstrong-Bond, E., Coyte, K. Z., Knight, C. G., Basler, M. & Brockhurst, M., 30 Jul 2024, bioRxiv, 24 p.Research output: Preprint/Working paper › Preprint
Open Access -
Bacterial defences: mechanisms, evolution and antimicrobial resistance
Smith, W. P. J., Wucher, B. R., Nadell, C. D. & Foster, K. R., 24 Apr 2023, In: Nature Reviews Microbiology.Research output: Contribution to journal › Review article › peer-review
Open AccessFile1576 Downloads (Pure)
Prizes
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The evolution of bacterial resistance to the Type 6 Secretion System
Smith, W. (Recipient), 1 Apr 2022
Prize: Fellowship awarded competitively
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LEAF Champion
Smith, W. (Other)
1 Jun 2023 → …Activity: Internal positions, career professional development, other peer review and other › Internal positions › Teaching and Research
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Microbiology Society (External organisation)
Smith, W. (Member)
1 Apr 2021 → …Activity: Membership › Membership of board › Research