• G.023, Manchester Institute of Biotechnology, John Garside Building, The University of Manchester, 131 Princess Street

    M1 7DN Manchester

    United Kingdom

  • MIB Stores, The Manchester Institute of Biotechnology, Drover Lane, off Sackville Street

    M1 6NG Manchester

    United Kingdom

Accepting PhD Students

PhD projects

1. Mechanistic investigation and new inhibitor design for antibiotic resistance-causing beta-lactamases (synthesis, structural biology (protein NMR and X-ray crystallography) , chemical biology, molecular biology)
2. Targeting sulfoglycolysis to tackle bacteria persistence (synthesis, NMR, structural biology, chemical biology, molecular biology, microbiology).
3. Mechanistic studies of DNA-repairing enzyme catalysis (Biochemistry, structural biology, NMR)
4. Designing activity-based probes and tools to quantitatively investigate sulfated glycans (synthesis, molecular biology, chemical biology)
5. Molecular and mechanistic insights on novel HAD superfamily phosphates in bacterial for industrial applications (biotechnology, structural biology, chemical biology)

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Personal profile


Yi (金轶)had a First-Class Hons BSc degree in Chemistry and an MSc degree in Organic Chemistry after completing her Master's thesis on the synthesis of transition state analogue inhibitors of phosphoserine phosphatase and phosphopeptides in the group of Professor Yufen Zhao at Xiamen University, China. In 2008, she was awarded the Overseas Research Studentship by British Council to pursue a PhD under the supervision of Professors Jon Waltho and Mike Blackburn at the University of Sheffield, UK. During this period, she expanded the usage of metal fluoride complexes as mimics of the phosphoryl group in various key enzymes in cellular signal transduction in NMR and crystallography. She stayed in the same lab as a postdoc for two years, working on the strain catalysis of DNA repairing enzyme UNG using multi-dimensional NMR. In 2014, she joined the group of Prof. Gideon Davies, FRS, FMedSci, in York Structural Biology Laboratory (YSBL), University of York, working on various carbohydrate processing enzymes, including glycosyl hydrolases in sulfoglycolytic pathways, and using activity-based-probes to trap glucuronidases in action. In May 2017, she became a group leader in Chemical Biology at Cardiff University, allowing her to start her independent research group. In August 2021, she was appointed as a Wellcome Trust Sir Henry Dale Fellow at Manchester Institute of Biotechnology (MIB), The Univesity of Manchester.

Her research focuses on tackling antibiotic resistance and bacterial persistence by studying mechanisms of enzymes and pathways in bacteria and humans. Her research covers a wide range of techniques, including organic synthesis, chemical biology, molecular biology, microbiology, protein NMR, protein X-ray crystallography, and bioinformatics e.g. Comparative Genomics and Genomic Enzymology (Enzyme Function Initiative - EFI tools)

She is also active in promoting women in science and EDI. She is a mentor for the Windsor Fellowship, helping to unlock the talent of the under-represented year-12 students.


My group

Joining the Jin Lab at MIB:

We are currently looking for creative and motivated MPhil, PhD and junior fellowship applicants and researchers with skills in organic chemistry, biochemistry, biophysical chemistry, microbiology, chemical biology and structural biology. You will have opportunities to work on a wide range of projects in the Jin Lab. 

If you already have IELTS results above 6.5 and wish to apply for Chinese Scholarship Council (CSC) studentships with us, please contact me before December each year for next year's entry. 

Those wishing to apply for a Postdoctoral Fellowship to join the Jin lab are encouraged to get in touch to discuss possibilities. A non-exhaustive list of organisations that offer Fellowships in chemical and biological sciences is as follows:

Wellcome Trust Early Career Awards

AXA Fellowship

EMBO Long-term Fellowship

HFSP Postdoctoral Fellowship

Marie Sklodowska-Curie Postdoctoral Fellowship

Newton International Fellowship

Leverhulme Early Career Fellowship

If you are interested in joining us, please get in touch by sending an email to yi.jin@manchester.ac.uk with your academic CV and your one-page personal statement attached. Please also state your means of funding. The self-funded UK and overseas students are welcome.

Supervision information

MIB UoM Lab: 

Dr Patrick Baumann, PDRA (Wellcome Trust funded, 2021 Nov - present)

Asso. Prof. Zhongyuan Li, visiting scholar (CSC funded, 2022 Dec - present)

As the main supervisor:

Sana Fairman, PhD candidate (UoM funded, 2022 Sept - present)

As a co-supervisor:

Iakovia Ttoffi, PhD candidate (Marie-Curie ITN funded, Iceni Glycoscience Ltd, 2021 Oct - present) with Prof. Rob Field, MIB, University of Manchester


Cardiff University Lab:

As the main supervisor:

Mochen (Mia) Dong, PhD candidate  (CSC funded,  2020 Oct - present)

Davide Zappala, PhD candidate (EPSRC funded, 2019 Apr - present)

As a co-supervisor:

Hannah Baird, PhD candidate (EPSRC DTP funded, 2021 Oct - present) with Dr Oliver Castell, School of Pharmacy, Cardiff University 

Alex Lander, PhD candidate (EPSRC funded, 2019 Oct - 2022 Dec) with Dr Louis Luk, School of Chemistry, Cardiff University


'Mechanistic and structural study of GAP-catalysed hydrolase activity in small G proteins'

Author: Baumann, Patrick., Graduated Nov 2021 

Supervisor: Jin, Yi 

Cardiff University administered thesis: Phd


CHEM20421 Fundamentals of Drug Discovery - 1st Semester

CHEM20412 Structure and Reactivity of Organic Molecules - 2nd Semester

CHEM88001 Biocatalysis - 1st Semester (PhD level)

Memberships of committees and professional bodies

2007 – present             Member of Biochemical Society

2009 – present             Member of the Royal Society of Chemistry (RSC)

2018 – present             Member of the American Chemical Society (ACS)

2021 – present             Chartered Chemist of the Royal Society of Chemistry (RSC)

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 1 - No Poverty
  • SDG 2 - Zero Hunger
  • SDG 3 - Good Health and Well-being
  • SDG 5 - Gender Equality
  • SDG 6 - Clean Water and Sanitation
  • SDG 9 - Industry, Innovation, and Infrastructure
  • SDG 14 - Life Below Water
  • SDG 15 - Life on Land
  • SDG 17 - Partnerships for the Goals

Education/Academic qualification

Doctor of Philosophy, Metal Fluorides as Probes for Enzyme Catalysed Phosphoryl Transfer, The University of Sheffield

1 Oct 200815 Mar 2012

Award Date: 3 Mar 2012

Master in Science, Synthesis and Stucture Study on Pyroglutamyl Dipeptides and Aminophosphonic Acids, Xiamen University

1 Sep 200531 Aug 2008

Award Date: 31 Aug 2008

Bachelor of Science, The design, synthesis and their applications for chiral catalysis of sulfide oxidation, Xiamen University

1 Sep 200131 Aug 2005

Award Date: 31 Aug 2005

Areas of expertise

  • QD Chemistry
  • Chemical Biology
  • Biotechnology
  • Organic chemistry
  • Protein NMR
  • Protein Crystallography
  • Enzymology
  • Inhibitor design
  • Pathway engineering
  • Enzyme engineering

Research Beacons, Institutes and Platforms

  • Biotechnology
  • Global inequalities
  • Manchester Institute of Biotechnology


  • Small G proteins
  • Glycosciences
  • Host/pathogen interactions
  • Mechanistic biochemistry
  • Antibiotic Resistance
  • DNA repair


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