Research output per year
Research output per year
G.023, Manchester Institute of Biotechnology, John Garside Building, The University of Manchester, 131 Princess Street
M1 7DN Manchester
United Kingdom
MIB Stores, The Manchester Institute of Biotechnology, Drover Lane, off Sackville Street
M1 6NG Manchester
United Kingdom
Accepting PhD Students
Yi (金轶)had a First-Class Hons BSc degree in Chemistry and an MSc degree in Organic Chemistry after completing her Master's thesis on the synthesis of transition state analogue inhibitors of phosphoserine phosphatase and phosphopeptides in the group of Professor Yufen Zhao at Xiamen University, China. In 2008, she was awarded the Overseas Research Studentship (ORS) by the British Council to pursue a PhD under the supervision of Professors Jon Waltho and Mike Blackburn at the University of Sheffield, UK. During this period, she expanded the usage of metal fluoride complexes as mimics of the phosphoryl group in various key enzymes in cellular signal transduction in NMR and crystallography. She stayed in the same lab as a postdoc for two years, working on the strain catalysis of DNA repairing enzyme UNG using multi-dimensional NMR. In 2014, she joined the group of Prof. Gideon Davies, FRS, FMedSci, in York Structural Biology Laboratory (YSBL), University of York, working on various carbohydrate processing enzymes, including glycosyl hydrolases in sulfoglycolytic pathways, and using activity-based-probes to trap glucuronidases in action. In May 2017, she became a group leader in Chemical Biology at Cardiff University, allowing her to start her independent research group. In August 2021, she was appointed as a Wellcome Trust Sir Henry Dale Fellow at the Manchester Institute of Biotechnology (MIB), The Univesity of Manchester. Yi is a 2024 RSC Horizon Prize awardee for her contribution as part of the team in developing an understanding of sulfosugar metabolism and the discovery of new enzymes and pathways of sulfur recycling.
Her expertise in fluorine chemistry, structural biology and mechanistic enzymology enables her to drive transformative research into the enzymes and pathways involved in bacterial persistence and antibiotic resistance. Her research covers a wide range of techniques, including organic synthesis, chemical biology, molecular biology, microbiology, protein NMR, protein X-ray crystallography, and bioinformatics e.g. Enzyme Function Initiative - EFI tools.
1. Advancing the fight against antibiotic resistance and bacterial persistence by conducting comprehensive investigations into the molecular mechanisms governing antibiotic effectiveness
References:
2. Expanding the application of metal fluoride complexes and protein fluorine labelling as investigative tools in the study of phosphoryl transfer enzymes, with the objective of deepening our understanding of cancer biology (small G proteins, phosphatases, and kinases) and informing drug discovery efforts
References:
3. Investigating naturally occurring organo-sulfur metabolism pathways by marine, soil, and gut bacteria through characterising enzymes and defining their molecular mechanisms - In collaboration with Spencer Williams's Group, University of Melbourn, Bio21 Institute, Australia.
References:
CHEM20421 Fundamentals of Drug Discovery - 1st Semester
2007 – present Member of Biochemical Society
2009 – present Member of the Royal Society of Chemistry (RSC)
2018 – present Member of the American Chemical Society (ACS)
2021 – present Chartered Chemist of the Royal Society of Chemistry (RSC)
We are currently looking for creative and motivated MPhil, PhD and junior fellowship applicants and researchers with skills in organic chemistry, biochemistry, biophysical chemistry, microbiology, chemical biology and structural biology. You will have opportunities to work on a wide range of projects in the Jin Lab.
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Doctor of Philosophy, Protein NMR and Enzymology, The University of Sheffield
Oct 2008 → Mar 2012
Master in Science, Organic Chemistry, Xiamen University
Sept 2005 → Aug 2008
Bachelor of Science, Chemistry, Xiamen University
Sept 2001 → Aug 2005
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article
Research output: Contribution to journal › Article › peer-review
Jin, Y. (PI)
1/08/21 → 31/07/26
Project: Research
Jin, Y. (Recipient), 2024
Prize: Prize (including medals and awards)
Jin, Y. (Recipient), 1 Feb 2018
Prize: Prize (including medals and awards)
Jin, Y. (Recipient), 1 Aug 2021
Prize: Fellowship awarded competitively
Jin, Y. (Plenary speaker)
Activity: Talk or presentation › Invited talk › Research
Jin, Y. (Speaker)
Activity: Talk or presentation › Invited talk › Research
Jin, Y. (Speaker)
Activity: Talk or presentation › Invited talk › Research
Jin, Y. (Speaker)
Activity: Talk or presentation › Invited talk › Research
Jin, Y. (Speaker)
Activity: Talk or presentation › Invited talk › Research