Research output per year
Research output per year
G.023, Manchester Institute of Biotechnology, John Garside Building, The University of Manchester, 131 Princess Street
M1 7DN Manchester
United Kingdom
MIB Stores, The Manchester Institute of Biotechnology, Drover Lane, off Sackville Street
M1 6NG Manchester
United Kingdom
Accepting PhD Students
PhD projects
1. Mechanistic investigation and new inhibitor design for antibiotic resistance-causing beta-lactamases (synthesis, structural biology (protein NMR and X-ray crystallography) , chemical biology, molecular biology)
2. Targeting sulfoglycolysis to tackle bacteria persistence (synthesis, NMR, structural biology, chemical biology, molecular biology, microbiology).
3. Mechanistic studies of DNA-repairing enzyme catalysis (Biochemistry, structural biology, NMR)
4. Designing activity-based probes and tools to quantitatively investigate sulfated glycans (synthesis, molecular biology, chemical biology)
5. Molecular and mechanistic insights on novel HAD superfamily phosphates in bacterial for industrial applications (biotechnology, structural biology, chemical biology)
Yi (金轶)had a First-Class Hons BSc degree in Chemistry and an MSc degree in Organic Chemistry after completing her Master's thesis on the synthesis of transition state analogue inhibitors of phosphoserine phosphatase and phosphopeptides in the group of Professor Yufen Zhao at Xiamen University, China. In 2008, she was awarded the Overseas Research Studentship by British Council to pursue a PhD under the supervision of Professors Jon Waltho and Mike Blackburn at the University of Sheffield, UK. During this period, she expanded the usage of metal fluoride complexes as mimics of the phosphoryl group in various key enzymes in cellular signal transduction in NMR and crystallography. She stayed in the same lab as a postdoc for two years, working on the strain catalysis of DNA repairing enzyme UNG using multi-dimensional NMR. In 2014, she joined the group of Prof. Gideon Davies, FRS, FMedSci, in York Structural Biology Laboratory (YSBL), University of York, working on various carbohydrate processing enzymes, including glycosyl hydrolases in sulfoglycolytic pathways, and using activity-based-probes to trap glucuronidases in action. In May 2017, she became a group leader in Chemical Biology at Cardiff University, allowing her to start her independent research group. In August 2021, she was appointed as a Wellcome Trust Sir Henry Dale Fellow at Manchester Institute of Biotechnology (MIB), The Univesity of Manchester.
Her research focuses on tackling antibiotic resistance and bacterial persistence by studying mechanisms of enzymes and pathways in bacteria and humans. Her research covers a wide range of techniques, including organic synthesis, chemical biology, molecular biology, microbiology, protein NMR, protein X-ray crystallography, and bioinformatics e.g. Comparative Genomics and Genomic Enzymology (Enzyme Function Initiative - EFI tools)
She is also active in promoting women in science and EDI. She is a mentor for the Windsor Fellowship, helping to unlock the talent of the under-represented year-12 students.
Joining the Jin Lab at MIB:
We are currently looking for creative and motivated MPhil, PhD and junior fellowship applicants and researchers with skills in organic chemistry, biochemistry, biophysical chemistry, microbiology, chemical biology and structural biology. You will have opportunities to work on a wide range of projects in the Jin Lab.
Our faculty FSE and University UoM both offer a number of PhD studentships that are also open to international students:
School of Natural Sciences Diversity PhD Scholarships
FSE Dean’s Doctoral Scholarship
UoM President's Doctoral Scholar (PDS) Award
Postgraduate Research Teaching Associate (PGRTA) Scholarships
If you already have IELTS results above 6.5 and wish to apply for Chinese Scholarship Council (CSC) studentships with us, please contact me before December each year for next year's entry.
Those wishing to apply for a Postdoctoral Fellowship to join the Jin lab are encouraged to get in touch to discuss possibilities. A non-exhaustive list of organisations that offer Fellowships in chemical and biological sciences is as follows:
Wellcome Trust Early Career Awards
Marie Sklodowska-Curie Postdoctoral Fellowship
Newton International Fellowship
Leverhulme Early Career Fellowship
If you are interested in joining us, please get in touch by sending an email to yi.jin@manchester.ac.uk with your academic CV and your one-page personal statement attached. Please also state your means of funding. The self-funded UK and overseas students are welcome.
MIB UoM Lab:
Dr Patrick Baumann, PDRA (Wellcome Trust funded, 2021 Nov - present)
Asso. Prof. Zhongyuan Li, visiting scholar (CSC funded, 2022 Dec - present)
As the main supervisor:
Sana Fairman, PhD candidate (UoM funded, 2022 Sept - present)
As a co-supervisor:
Cardiff University Lab:
As the main supervisor:
Mochen (Mia) Dong, PhD candidate (CSC funded, 2020 Oct - present)
Davide Zappala, PhD candidate (EPSRC funded, 2019 Apr - present)
As a co-supervisor:
Hannah Baird, PhD candidate (EPSRC DTP funded, 2021 Oct - present) with Dr Oliver Castell, School of Pharmacy, Cardiff University
Alex Lander, PhD candidate (EPSRC funded, 2019 Oct - 2022 Dec) with Dr Louis Luk, School of Chemistry, Cardiff University
'Mechanistic and structural study of GAP-catalysed hydrolase activity in small G proteins'
Author: Baumann, Patrick., Graduated Nov 2021
Supervisor: Jin, Yi
Cardiff University administered thesis: Phd
CHEM20421 Fundamentals of Drug Discovery - 1st Semester
CHEM20412 Structure and Reactivity of Organic Molecules - 2nd Semester
CHEM88001 Biocatalysis - 1st Semester (PhD level)
2007 – present Member of Biochemical Society
2009 – present Member of the Royal Society of Chemistry (RSC)
2018 – present Member of the American Chemical Society (ACS)
2021 – present Chartered Chemist of the Royal Society of Chemistry (RSC)
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Doctor of Philosophy, Metal Fluorides as Probes for Enzyme Catalysed Phosphoryl Transfer, The University of Sheffield
1 Oct 2008 → 15 Mar 2012
Award Date: 3 Mar 2012
Master in Science, Synthesis and Stucture Study on Pyroglutamyl Dipeptides and Aminophosphonic Acids, Xiamen University
1 Sep 2005 → 31 Aug 2008
Award Date: 31 Aug 2008
Bachelor of Science, The design, synthesis and their applications for chiral catalysis of sulfide oxidation, Xiamen University
1 Sep 2001 → 31 Aug 2005
Award Date: 31 Aug 2005
Research output: Contribution to journal › Article
Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Jin, Yi (Recipient), 1 Feb 2018
Prize: Prize (including medals and awards)
Jin, Yi (Recipient), 2008
Prize: Prize (including medals and awards)
Jin, Yi (Recipient), 1 Aug 2021
Prize: Fellowship awarded competitively
Yi Jin (Speaker)
Activity: Talk or presentation › Invited talk
Yi Jin (Speaker)
Activity: Talk or presentation › Invited talk
Yi Jin (Speaker)
Activity: Talk or presentation › Invited talk
Committee member -The Carbohydrate Group (Academic expert member)
Activity: Membership › Membership of committee
Yi Jin (Speaker)
Activity: Talk or presentation › Invited talk