Personal profile
Overview
My work as research fellow at the North West Center for Advanced Drug Delivery (NoWCADD) at Manchester Pharmacy School & the Nanomedicine Lab involves the development of innovative therapeutic and in vivo imaging approaches for cancer therapy and degenerative medicine. I am working specifically to advance the in vivo evaluation of new pharmaceutical nanotechnology in collaboration with AstraZeneca in order to enhance the clinical translation of novel therapeutics.
Research interests
My research interest lies in the development, testing and optimisation of selective triggerable cancer treatments in vitro and in vivo, using novel nano-sized drug delivery systems encapsulating chemotherapeutics and directing those towards either tumour cells or tumour vasculature. I am increasingly focused on the impact of improving drug bioavailability using external triggers such as mild hyperthermia. I am also interested in the importance of exploiting non-invasive imaging techniques that could allow personalized medical treatment. In this way the distribution and accumulation, of the chemotherapeutics, into the tumour can be monitored non-invasively and the therapeutic efficacy can be assessed in real-time. The main goal is to combine diagnosis and therapy through theranostics drug design that would be certainly more valuable for predicting and measuring the therapeutic response and render the clinical translation more feasible.
My current and future research priorities fit into three broad areas:
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In vivo evaluation of the therapeutic potential of novel drug delivery systems for cancer therapy.
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Biomedical imaging.
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Nanotechnology to enhance neuroprotection of the brain ischemic region post-stoke.
Memberships of committees and professional bodies
Member of the Academy of Pharmaceutical Sciences
Qualifications
2013 - PhD in Drug Delivery and Nanomedicine, Nanomedicine Lab, UCL School of Pharmacy, UK.
2009 - MSc in Drug Delivery, The School of Pharmacy, University of London, UK.
2004 -BSc degree in Pharmacy, College of Pharmacy, University of Baghdad, Iraq.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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A novel scavenging tool for cancer biomarker discovery based on the blood-circulating nanoparticle protein corona
Hadjidemetriou, M., Al-Ahmady, Z., Buggio, M., Swift, J. & Kostarelos, K., Jan 2019, In: Biomaterials. 188, p. 118-129 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Enhanced Intraliposomal Metallic Nanoparticle Payload Capacity Using Microfluidic-Assisted Self-Assembly
Al-ahmady, Z. S., Donno, R., Gennari, A., Prestat, E., Marotta, R., Mironov, A., Newman, L., Lawrence, M. J., Tirelli, N., Ashford, M. & Kostarelos, K., 2019, In: Langmuir. 35, 41, p. 13318-13331Research output: Contribution to journal › Article › peer-review
Open AccessFile66 Downloads (Pure) -
Selective Liposomal Transport through Blood Brain Barrier Disruption in Ischemic Stroke Reveals Two Distinct Therapeutic Opportunities
Al-Ahmady, Z. (Lead), Jasim, D., Wong, R., Haley, M., Coutts, G., Schiessl, I., Allan, S. (Corresponding) & Kostarelos, K. (Corresponding), 6 Nov 2019, In: ACS Nano. 13, 11, p. 12470–12486Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Downloads (Pure) -
Formation of protein corona in vivo affects drug release from temperature-sensitive liposomes
Al-Ahmady, Z. S., Hadjidemetriou, M., Gubbins, J. & Kostarelos, K., 28 Apr 2018, In: Journal of Controlled Release. 276, p. 157-167 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile144 Downloads (Pure) -
The Human In Vivo Biomolecule Corona onto PEGylated Liposomes: A Proof-of-Concept Clinical Study
Hadjidemetriou, M., McAdam, S., Garner, G., Thackeray, C., Knight, D., Smith, D., Al-Ahmady, Z., Mazza, M., Rogan, J., Clamp, A. & Kostarelos, K., 2018, In: Advanced Materials. 31, 4, 1803335.Research output: Contribution to journal › Article › peer-review