British Society for Rheumatology Rheumatoid Arthritis Register (BSRBR-RA)

2024

Association between body weight and tocilizumab effectiveness in rheumatoid arthritis: results from the BSRBR-RA

BSRBR-RA Contributors Group, Tsoi, M. F., Kearsley-Fleet, L., Azadbakht, N., Watson, K., Hyrich, K. L. & Bluett, J., 14 Sept 2024, (E-pub ahead of print) In: Rheumatology (Oxford, England). keae500.

Research output: Contribution to journal › Article › peer-review

Open Access

Evaluation of discontinuation for adverse events of JAK inhibitors and bDMARDs in an international collaboration of rheumatoid arthritis registers (the 'JAK-pot' study)

Aymon, R., Mongin, D., Bergstra, S. A., Choquette, D., Codreanu, C., De Cock, D., Dreyer, L., Elkayam, O., Huschek, D., Hyrich, K. L., Iannone, F., Inanc, N., Kearsley-Fleet, L., Koca, S. S., Kvien, T. K., Leeb, B. F., Lukina, G., Nordström, D. C., Pavelka, K. & Pombo-Suarez, M. & 9 others, Rodrigues, A., Rotar, Z., Strangfeld, A., Verschueren, P., Westermann, R., Zavada, J., Courvoisier, D. S., Finckh, A. & Lauper, K., 12 Mar 2024, In: Annals of the rheumatic diseases. 83, 4, p. 421-428 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Potential impact of European Medicines Agency measures to minimise risk of serious side effects on JAKi prescribing and utilisation in the UK

Tian, Z., Kearsley-Fleet, L., Galloway, J., Watson, K., Lunt, M., BSRBR-RA Contributors Group & Hyrich, K. L., 15 May 2024, In: Rheumatology. keae279.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

After JAK inhibitor failure: to cycle or to switch, that is the question - data from the JAK-pot collaboration of registries

Pombo-Suarez, M., Sanchez-Piedra, C., Gómez-Reino, J., Lauper, K., Mongin, D., Iannone, F., Pavelka, K., Nordström, D. C., Inanc, N., Codreanu, C., Hyrich, K. L., Choquette, D., Strangfeld, A., Leeb, B. F., Rotar, Z., Rodrigues, A., Kristianslund, E. K., Kvien, T. K., Elkayam, O. & Lukina, G. & 3 others, Bergstra, S. A., Finckh, A. & Courvoisier, D. S., 23 Jan 2023, In: Annals of the rheumatic diseases. 82, 2, p. 175-181 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Etanercept originator versus etanercept biosimilar for the treatment of rheumatoid arthritis as a first biologic: results from the BSRBR-RA

Kearsley-Fleet, L., Rokad, A., Tsoi, M. F., Zhao, S., Lunt, M., Watson, K., BSRBR-RA Contributors Group & Hyrich, K., 21 Mar 2023, In: Rheumatology (Print). kead127.

Research output: Contribution to journal › Article › peer-review

Open Access

Evaluation of serious infections, including Mycobacterium tuberculosis, during treatment with biologic disease-modifying anti-rheumatic drugs: does line of therapy matter?

Lauper, K., Kearsley-Fleet, L., Galloway, J., Watson, K., Hyrich, K. & Lunt, M., 18 Oct 2023, In: Rheumatology. 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Outcomes following switching from etanercept originator to etanercept biosimilar in 1024 RA patients: A matched-analysis of the BSRBR-RA.

Kearsley-Fleet, L., Rokad, A., Tsoi, M. F., Zhao, S. S., Lunt, M., Watson, K., BSRBR-RA Contributors Group & Hyrich, K., 6 Sept 2023, In: Rheumatology.

Research output: Contribution to journal › Article › peer-review

Open Access

Socioeconomic deprivation is associated with reduced response and lower treatment persistence with TNF inhibitors in rheumatoid arthritis

Zhao, S. S., Rogers, K., Kearsley-Fleet, L., Watson, K., Bosworth, A., Galloway, J., Verstappen, S., Plant, D., BSRBR-RA Contributors Group, BRAGGSS, Barton, A., Hyrich, K. L. & Humphreys, J. H., 2 Jun 2023, In: Rheumatology.

Research output: Contribution to journal › Article › peer-review

Open Access

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2022

Effectiveness of sequential biologic and targeted disease modifying anti-rheumatic drugs for rheumatoid arthritis

Zhao, S. S., Kearsley-Fleet, L., Bosworth, A., Watson, K., BSRBR-RA Contributors Group & Hyrich, K. L., 1 Dec 2022, In: Rheumatology (Print). 61, 12, p. 4678-4686 9 p., keac190.

Research output: Contribution to journal › Article › peer-review

Open Access

Effectiveness of TNF-inhibitors, abatacept, IL6-inhibitors and JAK-inhibitors in 31,846 patients with rheumatoid arthritis in 19 registers from the “JAK-pot” collaboration

Lauper, K., Ludici, M., Mongin, D., Bergstra, S., Choquette, D., Codreanu, C., Cordtz, R., De Cock, D., Dreyer, L., Elkayam, O., Hauge, E., Huschek, D., Hyrich, K., Iannone, F., Inanc, N., Kearsley-Fleet, L., Kristianslund, E., Kvien, T., Leeb, B. & Lukina, G. & 9 others, Nordström, D., Pavelka, K., Pombo-Suarez, M., Rotar, Z., Santos, M., Strangfeld, A., Verschueren, P., Courvoisier, D. & Finckh, A., 15 Jun 2022, In: Annals of the rheumatic diseases. 81, 10, p. 1358-1366 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Demyelinating Events Following Initiation of Anti-TNFα Therapy in the British Society for Rheumatology Biologics Registry in Rheumatoid Arthritis

British Society for Rheumatology Biologics Register & Hyrich, K., 1 May 2021, In: Neurology: Neuroimmunology & Neuroinflammation. 8, 3

Research output: Contribution to journal › Article › peer-review

Open Access

Nonserious Infections in Patients With Rheumatoid Arthritis: Results From the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

British Society for Rheumatology Biologics Register, Bechman, K., Halai, K., Yates, M., Norton, S., Cope, A. P., Hyrich, K. & Galloway, J., Oct 2021, In: Arthritis & Rheumatology (Hoboken). 73, 10, p. 1800-1809 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Avoiding pitfalls when combining multiple imputation and propensity scores

Granger, E., Sergeant, J. & Lunt, M., 20 Nov 2019, In: Statistics in medicine. 38, 26, p. 5120-5132

Research output: Contribution to journal › Article › peer-review

Open Access

Cervical screening uptake and rates of cervical dysplasia in the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

BSRBR-RA Control Centre Consortium, 5 Aug 2019, In: Rheumatology (Oxford).

Research output: Contribution to journal › Article › peer-review

Open Access

Early response to anti-TNF predicts long-term outcomes including sustained remission: an analysis of the BSRBR-RA

BSRBR-RA Contributors Group, 12 Nov 2019, (E-pub ahead of print) In: Rheumatology (Oxford).

Research output: Contribution to journal › Article › peer-review

Open Access

Gender stratified adjustment of the DAS28-CRP improves inter-score agreement with the DAS28-ESR in rheumatoid arthritis

BSRBR-RA Contributors Group, 1 May 2019, In: Rheumatology (United Kingdom). 58, 5, p. 831-835 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Impact of TNF inhibitor therapy on joint replacement rates in rheumatoid arthritis: a matched cohort analysis of UK registry data

Hawley, S., Sanni Ali, M., Cordtz, R., Dreyer, L., Edwards, C. J., Arden, N. K., Cooper, C., Judge, A., Hyrich, K. & Prieto-Alhambra, D., 2019, In: Rheumatology.

Research output: Contribution to journal › Article › peer-review

Open Access

Malignancy and mortality rates in patients with severe psoriatic arthritis requiring tumour-necrosis factor alpha inhibition: results from the British Society for Rheumatology Biologics Register

Fagerli, K. M., Kearsley-Fleet, L., Mercer, L. K., Watson, K., Packham, J., Symmons, D. P. M., Hyrich, K. L. & British Society for Rheumatology Biologics Register, 1 Jan 2019, In: Rheumatology (Oxford, England). 58, 1, p. 80-85

Research output: Contribution to journal › Article › peer-review

Open Access

Not all moderate disease is the same – Identification of disability trajectories among patients with rheumatoid arthritis and moderate disease activity

Pan, Y., Norton, S., Gwinnutt, J., Kearsley-Fleet, L., Symmons, D., Lunt, M., Young, A., BSRBR-RA Control Centre Consortium, Hyrich, K. & Verstappen, S., 2019, In: P L o S One. 14, 5, e0215999.

Research output: Contribution to journal › Article › peer-review

Open Access

Polypharmacy is associated with treatment response and serious adverse events: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

British Society for Rheumatology Biologics Register, Bechman, K., Clarke, B. D., Rutherford, A. I., Yates, M., Nikiphorou, E., Molokhia, M., Norton, S., Cope, A. P., Hyrich, K. & Galloway, J. B., Oct 2019, In: Rheumatology (Oxford). 58, 10, p. 1767-1776 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Predictors, demographics and frequency of sustained remission and low disease activity in anti-tumour necrosis factor–treated rheumatoid arthritis patients

British Society for Rheumatology Biologics Register, Hamann, P. D. H., Pauling, J. D., McHugh, N., Shaddick, G. & Hyrich, K., Dec 2019, In: Rheumatology (Oxford). 58, 12, p. 2162-2169 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Biologic Prescribing Decisions Following Serious Infection; Results from the British Society for Rheumatology Biologics Register – Rheumatoid Arthritis (BSRBR-RA)

Subesinghe, S., Rutherford, A. I., Byng-Maddick, R., Hyrich, K. & James B Galloway, Dec 2018, In: Rheumatology. 57, 12, p. 2096-2100

Research output: Contribution to journal › Article › peer-review

Open Access

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Biologic Refractory Disease in Rheumatoid Arthritis: Results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

Kearsley-Fleet, L., Davies, R., De Cock, D., Watson, K., Lunt, M., Buch, M., Isaacs, J. D., Hyrich, K. & BSRBR-RA Contributors Group, Oct 2018, In: Annals of the rheumatic diseases. 77, 10, p. 1405-1412

Research output: Contribution to journal › Article › peer-review

Open Access

Long-Term Persistence of TNF-Inhibitor Treatment in Patients with Psoriatic Arthritis. Data from the British Society for Rheumatology Biologics Register.

Fagerli, K. M., Kearsley-Fleet, L., Watson, K., Packham, J., BSRBR-RA Contributors Group, Symmons, D. & Hyrich, K., 2018, In: RMD Open. 4, 1, p. e000596 e000596.

Research output: Contribution to journal › Article › peer-review

Open Access

Long-term Persistence with Rituximab in Patients with Rheumatoid Arthritis

Oldroyd, A., Symmons, D., Sergeant, J., Kearsley-Fleet, L., Watson, K., Lunt, M., Hyrich, K. & BSRBR-RA Contributors Group, Jun 2018, In: Rheumatology. 57, 6, p. 1089-1096

Research output: Contribution to journal › Article › peer-review

Open Access

Opportunistic infections in rheumatoid arthritis patients exposed to biologic therapy: Results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

Rutherford, A. I., Patarata, E., Subesinghe, S., Hyrich, K. L. & Galloway, J. B., 1 Jun 2018, In: Rheumatology (United Kingdom). 57, 6, p. 997-1001 5 p.

Research output: Contribution to journal › Article › peer-review

Recurrent serious infections in patients with rheumatoid arthritis-Results from the British Society for Rheumatology Biologics Register

Subesinghe, S., Rutherford, A. I., Byng-Maddick, R., Hyrich, K. L. & Galloway, J. B., 1 Apr 2018, In: Rheumatology (United Kingdom). 57, 4, p. 651-655 5 p.

Research output: Contribution to journal › Article › peer-review

Serious infection across biologic treated patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

Rutherford, A. I., Subesinghe, S., Hyrich, K. & Galloway, J., 2018, In: Annals of the rheumatic diseases. 77, 6, p. 905-910

Research output: Contribution to journal › Article › peer-review

Open Access

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Serious infection risk after 1 year between patients with rheumatoid arthritis treated with rituximab or with a second TNFi after initial TNFi failure: results from The British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

Silva-Fernandez, L., Decock, D., Lunt, M., Low, A., Watson, K., BSRBR-RA Contributors Group, Symmons, D. & Hyrich, K., 2018, In: Rheumatology. 57, 9, p. 1533-1540

Research output: Contribution to journal › Article › peer-review

Open Access

The influence of TNF inhibitors on dementia incidence in patients with rheumatoid arthritis; an analysis from the BSRBR-RA

McGuinness, B., Holmes, C., Mirakhur, A., Kearsley-Fleet, L., Vieira, R., Watson, K., BSRBR-RA Contributors Group, BSRBR-RA Control Centre Consortium & Hyrich, K., 1 Mar 2018, In: International journal of geriatric psychiatry. 33, 3, p. 556-558 3 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

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The relationship between depression and biologic treatment response in rheumatoid arthritis: An analysis of the British Society for Rheumatology Biologics Register.

Matcham, F., Davies, R., Hotopf, M., Hyrich, K., Norton, S., Steer, S. & Galloway, J., 1 May 2018, In: Rheumatology. 57, 5, p. 835-843

Research output: Contribution to journal › Article › peer-review

Open Access

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2017

Does sex or ethnicity impact anti-tumour necrosis factor agent use in rheumatoid arthritis?

Dennison, E. M., Jameson, K. A., Marks, J., Watson, K., Hyrich, K., Symmons, D. & Cooper, C. C., 1 Apr 2017, In: Rheumatology (Print). 56, 4, p. 663-665 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Drug-specific risk and characteristics of lupus and vasculitis-like events in rheumatoid arthritis patients treated with TNFi: results from BSRBR-RA

Jani, M., Dixon, W., Kearsley-Fleet, L., Bruce, I., Chinoy, H., Barton, A., Lunt, M., Watson, K., BSRBR-RA Control Centre Consortium, Symmons, D. & Hyrich, K., 21 Jan 2017, In: RMD Open. 3, 1, p. e000314

Research output: Contribution to journal › Article › peer-review

Open Access

Factors Associated with Sustained Remission in Rheumatoid Arthritis in Patients Treated with Anti-Tumour Necrosis Factor (anti-TNF)

Hamann, P. D. H., Holland, R., Hyrich, K., Pauling, J. D., Shaddick, G., Nightingale, A. & McHugh, N., 8 May 2017, In: Arthritis Care & Research. 69, 6, p. 783-793

Research output: Contribution to journal › Article › peer-review

Open Access

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Identification and validation of clinically relevant clusters of severe fatigue in rheumatoid arthritis.

Basu, N., Jones, G. T., Macfarlane, G. J. & Druce, K., 2017, In: Psychosomatic Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

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Mortality in Patients with Interstitial Lung Disease Treated with Rituximab or TNFi as a First Biologic

Druce, K., Iqbal, K., Watson, K., Symmons, D., BSRBR-RA Investigators Group, Hyrich, K. & Kelly, C., 1 Jul 2017, In: RMD Open. 3, 1, e000473.

Research output: Contribution to journal › Article › peer-review

Open Access

Pregnancy outcomes in women with rheumatoid arthritis ever treated with rituximab

Decock, D., Birmingham, L., Watson, K., Kearsley-Fleet, L., BSRBR Control Centre Consortium, Symmons, D. & Hyrich, K., 27 Jan 2017, In: Rheumatology (Oxford). 56, 4, p. 661-663

Research output: Contribution to journal › Letter › peer-review

Relationship between exposure to tumour necrosis factor inhibitor therapy and incidence and severity of myocardial infarction in patients with rheumatoid arthritis

Low, A., Symmons, D., Lunt, M., Mercer, L., Gale, C., Watson, K., Dixon, W. & Hyrich, K., 2017, In: Annals of the rheumatic diseases. 76, 4, p. 654-660

Research output: Contribution to journal › Article › peer-review

Open Access

Risk of lymphoma in patients exposed to antitumour necrosis factor therapy: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

BSRBR Control Centre Consortium, Mercer, L., Galloway, J. B., Lunt, M., Davies, R., Low, A., Dixon, W., Watson, K., Symmons, D. & Hyrich, K., 1 Mar 2017, In: Annals of the rheumatic diseases. 76, 3, p. 497-503 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The spectrum of lymphomas across different drug treatment groups in rheumatoid arthritis: a European registries collaborative project

Mercer, L., Regierer, A., Mariette, X., Dixon, W., Baecklund, E., Hellgren, K., Dreyer, L., Lund Hetland, M., Cordtz, R., Hyrich, K., Strangfeld, A., Zink, A., Canhao, H., Hernández, M. V., Tubach, F., Gottenberg, J.-E., Morel, J., Zavada, J., Iannone, F. & Askling, J. & 1 others, Listing, J., 2017, In: Annals of the rheumatic diseases. 76, 12, p. 2025-2030

Research output: Contribution to journal › Article › peer-review

Open Access

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Use and effectiveness of tocilizumab among patients with rheumatoid arthritis: An observational study from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

Kihara, M., Davies, R., Kearsley-Fleet, L., Watson, K., Lunt, M., Symmons, D. & Hyrich, K., Feb 2017, In: Clinical Rheumatology. 36, 2, p. 241-250 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

Association between ischaemic stroke and tumour necrosis factor inhibitor therapy in patients with rheumatoid arthritis.

Low, A. S. L., Lunt, M., Mercer, L. K., Watson, K. D., Dixon, W. G., Symmons, D. P. M. & Hyrich, K. L., 2016, In: Arthritis & rheumatology (Hoboken, N.J.). 68, 6, p. 1337–1345

Research output: Contribution to journal › Article › peer-review

Open Access

Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data

British Society for Rheumatology Biologics Register, 13 Dec 2016, In: Arthritis Research & Therapy. 18, 295, p. 1-12 12 p., 295.

Research output: Contribution to journal › Article › peer-review

Open Access

Effectiveness and Safety of TNF Inhibitors in Adults with Juvenile Idiopathic Arthritis

Kearsley-Fleet, L., McErlane, F., Foster, H. E., Lunt, M., Watson, K., Symmons, D. & Hyrich, K., 7 Oct 2016, In: RMD Open. 2, 2, e000273.

Research output: Contribution to journal › Article › peer-review

Open Access

Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: Results from the British society for rheumatology biologics register

British Society for Rheumatology Biologics Register, 12 Aug 2016, In: BMC Musculoskeletal Disorders. 17, p. 1-17 17 p., 337.

Research output: Contribution to journal › Article › peer-review

Open Access

Most patients who reach disease remission following anti-TNF therapy continue to report fatigue: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

Druce, K., Bhattacharya, Y., Jones, G. T., Macfarlane, G. J. & Basu, N., Oct 2016, In: Rheumatology (Oxford, England). 55, 10, p. 1786-1790

Research output: Contribution to journal › Article › peer-review

Risk of invasive melanoma in patients with rheumatoid arthritis treated with biologics: results from a collaborative project of 11 European biologic registers

Mercer, L., Askling, J., Raaschou, P., Dixon, W., Dreyer, L., Lund Hetland, M., Strangfeld, A., Zink, A., Mariette, X., Finckh, A., Canhao, H., Iannone, F., Zavada, J., Morel, J., Gottenberg, J.-E., Hyrich, K. & Listing, J., 15 Jun 2016, In: Annals of the rheumatic diseases. 76, 2, p. 386-391

Research output: Contribution to journal › Article › peer-review

Open Access

Risk of Pneumocystis jirovecii pneumonia in patients with rheumatoid arthritis treated with inhibitors of tumour necrosis factor α: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.

Bruce, E. S., Kearsley-Fleet, L., Watson, K., Symmons, D. & Hyrich, K., 2016, In: Rheumatology. 55, 7, p. 1336-1337 2 p.

Research output: Contribution to journal › Letter › peer-review

The incidence of cancer in patients with rheumatoid arthritis and a prior malignancy who receive TNFi or rituximab: results from the British Society for Rheumatology Biologics Register-Rheumatoid Arthritis

BSRBR Control Centre Consortium, Silva-Fernandez, L., Lunt, M., Kearsley-Fleet, L., Watson, K., Dixon, W., Symmons, D. & Hyrich, K., Nov 2016, In: Rheumatology. 55, 11, p. 2033-2039 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2015

Consistency and utility of data items across European rheumatoid arthritis clinical cohorts and registers.

Radner, H., Dixon, W., Hyrich, K. & Askling, J., 2015, In: Arthritis Care & Research. 67, 9, p. 1219-29

Research output: Contribution to journal › Article › peer-review

British Society for Rheumatology Rheumatoid Arthritis Register (BSRBR-RA)

Research output

Search results