Research output per year
Research output per year
Project Details
Description
The University of Manchester is home to the largest biological timing research community in Europe. Led by Professor Robert Lucas, we bring together world-leading researchers with a multidisciplinary approach to cellular timers and circadian clocks.
Our research spans from model organisms and understanding of fundamental cellular events, through to clinical intervention into human diseases, including diabetes and inflammatory arthritis.
Biological timing is a central feature of all living things. Driven by endogenous biological clocks, the ability to track time allows organisms to adapt their biology and thus optimally respond to the fluctuating environment of our planet.
Critical to this is the role of internal timers in coordinating innumerable cellular and physiological processes, which drive our development and biology, from gene expression to behaviour.
Our research spans from model organisms and understanding of fundamental cellular events, through to clinical intervention into human diseases, including diabetes and inflammatory arthritis.
Biological timing is a central feature of all living things. Driven by endogenous biological clocks, the ability to track time allows organisms to adapt their biology and thus optimally respond to the fluctuating environment of our planet.
Critical to this is the role of internal timers in coordinating innumerable cellular and physiological processes, which drive our development and biology, from gene expression to behaviour.
| Short title | Bio-timing |
|---|---|
| Status | Not started |
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
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Altered proportions of retinal cell types and distinct visual codes in rodents occupying divergent ecological niches
Allen, A. E., Hahn, J., Richardson, R., Pantiru, A., Mouland, J., Babu, A., Baño-Otalora, B., Monavarfeshani, A., Yan, W., Williams, C., Wynne, J., Rodgers, J., Milosavljevic, N., Orlowska-Feuer, P., Storchi, R., Sanes, J. R., Shekhar, K. & Lucas, R. J., 7 Apr 2025, In: Current biology . 35, 7, p. 1446-1458.e5Research output: Contribution to journal › Article › peer-review
Open Access -
Colonic inflammation modulates the intestinal circadian landscape
Butler, T., Downton, P., Dickson, S., Luengas Martinez, A., Simpkins, D., Khoo, I., Veal, S., West, A., Adamson, A., Bechtold, D., Mclaughlin, J. & Gibbs, J., 18 Jul 2025, (Accepted/In press) In: iScience.Research output: Contribution to journal › Article › peer-review
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Guanine is an inhibitor of c-Jun terminal kinases
Treeby, J., El Sayed, S., Morgan, S., Maddock, S., Taylor, G., Warwood, S., Selley, J., Knight, D., Saer, B., Bryce, R. & Fustin, J.-M., 30 May 2025, Research Square, p. 1-29, 29 p.Research output: Preprint/Working paper › Preprint
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Neural circuitry determining nocturnal and diurnal physiology and behaviour
Brown, T. (PI) & Bechtold, D. (CoI)
1/05/23 → 30/04/26
Project: Research
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The Nucleus Reuniens as a key control point for effects of light on learning and memory
Brown, T. (PI), Gigg, J. (CoI) & Lucas, R. (CoI)
1/05/23 → 30/06/27
Project: Research
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New paradigms in fibroblasts and immune cells coordinate in matrix homeostasis in health and disease
Chang, J. (PI)
1/04/22 → 31/03/27
Project: Research
Activities
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Faster clock in mice and cells lacking mRNA cap methylation
Fustin, J.-M. (Speaker)
25 Aug 2025Activity: Talk or presentation › Oral presentation › Research
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Winter Symposium of the Centre for Biological Timing
Fustin, J.-M. (Chair)
16 Jan 2024Activity: Participating in or organising event(s) › Organising a conference, workshop, exhibition, performance, inquiry, course etc › Research
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Summer Symposium of the Centre for Biological Timing
Fustin, J.-M. (Chair)
19 Jul 2022Activity: Participating in or organising event(s) › Organising a conference, workshop, exhibition, performance, inquiry, course etc › Research
Prizes
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Future Leaders Fellowship (renewal)
Fustin, J.-M. (Recipient), 14 Jul 2023
Prize: Fellowship awarded competitively
Datasets
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Guanine is an inhibitor of c-Jun terminal kinases
Fustin, J.-M. (Creator), Knight, D. (Contributor), Selley, J. (Contributor) & Warwood, S. (Contributor), ProteomeXchange, 2 Jul 2025
DOI: 10.6019/PXD062305
Dataset
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Effect of methionine/choline deficient diet on liver and suprachiasmatic nucleus circadian transcriptome.
Fustin, J.-M. (Creator), National Center for Biotechnology Information, 5 Jan 2024
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE252364
Dataset