Grand Challenge Network in Network+ in Proton Therapy.

Research output

Research output per year 2015 2019 2020 2021 2023

• 39 Article
• 1 Letter
• 1 Other contribution

Research output per year

Research output per year

Search results

• 2023

  Proposing a clinical model for RBE based on proton track-end counts

  Henthorn, N., Gardner, L. L., Aitkenhead, A., Rowland, B., Shin, J., Smith, E., Merchant, M., Mackay, R., Kirkby, K., Chaudhary, P., Prise, K. M., McMahon, S. & Underwood, T., 13 Jan 2023, (E-pub ahead of print) In: International Journal of Radiation: Oncology - Biology - Physics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Metrics 100%
  • Clinical Application 100%
  • Patient Treatment 100%
  • Statistical Property 100%
  • Relative Biologic Effectiveness 100%
  16 Downloads (Pure)
• 2022

  An Update to the Malthus Model for Radiotherapy Utilisation in England

  Heritage, S., Sundaram, S., Kirkby, N. F., Kirkby, K. J., Mee, T. & Jena, R., 11 Jul 2022, (E-pub ahead of print) In: Clinical oncology (Royal College of Radiologists (Great Britain)).

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tree 100%
  • Radiation Therapy 100%
  • Malignant Neoplasm 66%
  • Disease 66%
  • Cancer Incidence 66%

• Estimating the percentage of patients who might benefit from proton beam therapy instead of X-ray radiotherapy

  Burnet, N. G., Mee, T., Gaito, S., Kirkby, N. F., Aitkenhead, A. H., Anandadas, C. N., Aznar, M. C., Barraclough, L. H., Borst, G., Charlwood, F. C., Clarke, M., Colaco, R. J., Crellin, A. M., Defourney, N. N., Hague, C. J., Harris, M., Henthorn, N. T., Hopkins, K. I., Hwang, E. & Ingram, S. P. & 25 others, Kirkby, K. J., Lee, L. W., Lines, D., Lingard, Z., Lowe, M., Mackay, R. I., McBain, C. A., Merchant, M. J., Noble, D. J., Pan, S., Price, J. M., Radhakrishna, G., Reboredo-Gil, D., Salem, A., Sashidharan, S., Sitch, P., Smith, E., Smith, E. A., Taylor, M. J., Thomson, D. J., Thorp, N. J., Underwood, T. S., Warmenhoven, J. W., Wylie, J. P. & Whitfield, G., 1 May 2022, In: The British journal of radiology. 95, 1133, 20211175.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Radiation Therapy 100%
  • Proton Therapy 100%
  • Malignant Neoplasm 100%
  • Second Cancer 100%
  • UK 100%

• In regard to Van Marlen: FLASH radiotherapy: Considerations for multibeam and hypofractionation dose delivery

  Mackay, R., Burnet, N., Matthew, L., Rothwell, B., Kirkby, N., Kirkby, K. & Hendry, J., 1 Feb 2022, In: Radiotherapy and Oncology. 167, p. 328-329 2 p.

  Research output: Contribution to journal › Letter › peer-review

• The suitability of micronuclei as markers of relative biological effect

  Heaven, C. J., Wanstall, H. C., Henthorn, N. T., Warmenhoven, J.-W., Ingram, S. P., Chadwick, A. L., Santina, E., Honeychurch, J., Schmidt, C. K., Kirkby, K. J., Kirkby, N. F., Burnet, N. G. & Merchant, M. J., 2 Apr 2022, In: Mutagenesis. 37, 1, p. 3-12 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Micronucleus 100%
  • Particle Type 100%
  • Collating 100%
  • In Vitro 12%
  • DNA Damage 12%
• 2021

  A Monte Carlo study of different LET definitions and calculation parameters for proton beam therapy

  Smith, E. A. K., Winterhalter, C., Underwood, T. S. A., Aitkenhead, A. H., Richardson, J. C., Merchant, M. J., Kirkby, N. F. & Mackay, R. I., 17 Dec 2021, In: Biomedical Physics & Engineering Express . 8, 1, 015024.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proton Therapy 100%
  • Linear Energy Transfer 100%
  • Neoplasm 100%
  • Heavy Ion 100%
  • Relative Biologic Effectiveness 17%

• Determining the parameter space for effective oxygen depletion for FLASH radiation therapy

  Rothwell, B., Kirkby, N., Merchant, M., Chadwick, A., Lowe, M., Mackay, R., Hendry, J. & Kirkby, K., 25 Feb 2021, In: Physics in Medicine & Biology. 66, 5, 055020.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dose Rate 100%
  • Radiotherapy 100%
  • Parameter Space 100%
  • Radiation Therapy 100%
  • Drug Megadose 100%

• FLASH radiotherapy: Considerations for multibeam and hypofractionation dose delivery,

  Mackay, R., Burnet, N., Matthew, L., Rothwell, B., Kirkby, N., Kirkby, K. & Hendry, J., 14 Oct 2021, In: Radiotherapy & Oncology. 164, p. 122-127 6 p.

  Research output: Contribution to journal › Article › peer-review

• Mechanistic Modelling of Slow and Fast NHEJ DNA Repair Pathways Following Radiation for G0/G1 Normal Tissue Cells

  Qi, Y., Warmenhoven, J., Henthorn, N., Ingram, S., XG, X., Kirkby, K. & Merchant, M., 3 May 2021, In: Cancers. 13, 9, 2202.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Non-Homologous End Joining 100%
  • Surgery 100%
  • Cell Cycle 33%
  • In Silico 33%
  • Nuclease 33%

• Oxygen depletion in proton spot scanning: a tool for exploring the conditions needed for FLASH

  Rothwell, B., Lowe, M., Kirkby, N., Merchant, M., Chadwick, A., Mackay, R., Hendry, J. & Kirkby, K., 22 Nov 2021, In: Radiation. 1, 4, p. 290-304 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Facilitated Diffusion 100%
  • Computer Model 100%
  • Drug Megadose 100%
  • Radiation Therapy 100%
  • Tumor 100%

• Towards harmonizing clinical linear energy transfer (LET) reporting in proton radiotherapy: A European multi-centric study

  Hahn, C., Dasu, A., Vestergaard, A., Fulsang Jensen, M., Sokol, O., Pardi, C., Bourhaleb, F., Leite, A., de Marzi, L., Smith, E., Aitkenhead, A., Rose, C., Merchant, M., Kirkby, K., Grzanka, L., Pawelke, J. & Luhr, A., 22 Oct 2021, In: Acta Oncologica . p. 1-9 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Europeans 100%
  • Neoplasm 100%
  • Secondary Particle 50%
  48 Downloads (Pure)
• 2020

  An open source heterogeneous 3D printed mouse phantom utilising a novel bone representative thermoplastic

  Price, G. J., Biglin, E. R., Collins, S., Aitkenhead, A. H., Subiel, A., Chadwick, A. L., Cullen, D. M., Kirkby, K. J., Schettino, G., Tipping, J. & Robinson, A., 2020, In: Physics in Medicine and Biology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation Therapy 100%
  • Dosimetry 100%
  • Reproductive Medicine 100%
  • Skeleton 100%
  • Body Surface 100%
  316 Downloads (Pure)

• Characterization of a pixelated silicon microdosimeter in micro-beams of light ions

  Pola, A., Bortot, D., Mazzucconi, D., Fazzi, A., Galer, S., Kirkby, K. J., Merchant, M. J., Palmans, H. & Agosteo, S., Apr 2020, In: Radiation Measurements. 133, 106296.

  Research output: Contribution to journal › Article › peer-review

  • Light Ion 100%
  • Proportional Counter 100%
  • Microbeam 100%
  • Collection Efficiency 100%
  • Ion Beams 50%

• Characterizing local dose perturbations due to gas cavities in Magnetic Resonance guided Radiotherapy

  Shortall, J., Vasquez Osorio, E., Chuter, R., Green, A., Mcwilliam, A., Kirkby, K., Mackay, R. & Van Herk, M., 6 Mar 2020, (E-pub ahead of print) In: Medical Physics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation Therapy 100%
  • Nuclear Magnetic Resonance 100%
  • Dose Response 44%
  • Dose Calculation 22%
  • Magnetic Resonance Imaging 11%
  50 Downloads (Pure)

• Evaluation of GATE‐RTion (GATE/Geant4) Monte Carlo simulation settings for proton pencil beam scanning quality assurance

  Winterhalter, C., Taylor, M., Boersma, D., Elia, A., Guatelli, S., Mackay, R., Kirkby, K., Maigne, L., Ivanchenko, V., Resch, A. F., Sarrut, D., Sitch, P., Vidal, M., Grevillot, L. & Aitkenhead, A., 23 Sept 2020, (E-pub ahead of print) In: Medical Physics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Computer Assisted Tomography 100%
  • Monte Carlo Method 100%
  • Proton Therapy 20%
  • Dose Calculation 20%

• Experimental verification the Electron Return Effect around spherical air cavities for the MR Linac using Monte Carlo calculation

  Shortall, J., Vasquez Osorio, E., Mackay, R., Aitkenhead, A., Kirkby, K., Budgell, G., Agnew, J., Mcwilliam, A., Chuter, R. & Van Herk, M., 7 Mar 2020, (E-pub ahead of print) In: Medical Physics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Linear Accelerator 100%
  • Phantom 100%
  • Poly(methyl Methacrylate) 100%
  • Treatment Planning 100%
  • Monte Carlo 100%
  68 Downloads (Pure)

• Hi-C implementation of genome structure for in silico models of radiation-induced DNA damage

  Ingram, S. P., Henthorn, N. T., Warmenhoven, J. W., Kirkby, N. F., Mackay, R. I., Kirkby, K. J. & Merchant, M. J., 16 Dec 2020, In: PLoS computational biology. 16, 12, e1008476.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genomic Structure 100%
  • Computer Model 100%
  • DNA Damage 100%
  • Conformation 50%
  • Genome Organization 50%
  124 Downloads (Pure)

• Insights into the Non-Homologous End Joining Pathway and Double Strand Break End Mobility Provided by Mechanistic In Silico Modelling

  Warmenhoven, J., Henthorn, N., Ingram, S., Chadwick, A., Sotiropoulos, M., Korabel, M., Fedotov, S., Mackay, R., Kirkby, K. & Merchant, M., Jan 2020, In: DNA Repair.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Computer Model 100%
  • Non-Homologous End Joining 100%
  • Behavior (Neuroscience) 100%
  • Double Stranded DNA 100%
  • Radiation Exposure 100%

• Inter- and intra-fractional stability of rectal gas in pelvic cancer patients during MRIgRT

  Shortall, J., Vasquez Osorio, E., Mackay, R., Song, Y. P., Kirkby, K., Cree, A., Dubec, M., Chuter, R., Mcwilliam, A., Price, G. & Van Herk, M., 9 Nov 2020, (E-pub ahead of print) In: Medical Physics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation Therapy 100%
  • Magnetic Resonance Imaging 100%
  • Pelvis Cancer 100%
  • Pelvis 100%
  • Rectum 57%
  148 Downloads (Pure)

• Mapping the Future of Particle Radiobiology in Europe: The INSPIRE Project

  Henthorn, N., Kirkby, K., Merchant, M. & Warmenhoven, J., 6 Oct 2020, In: Frontiers in Physics. 8, 565055.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sample Preparation 100%
  • Particle Type 100%
  • Malignant Neoplasm 100%

• Proton Beam Therapy – perspectives on the National Health Service England clinical service and research programme

  Burnet, N., Mackay, R., Smith, E. R., Chadwick, A., Whitfield, G., Thomson, D., Lowe, M., Kirkby, N., Crellin, A. M. & Kirkby, K., 1 Mar 2020, In: British Journal of Radiology. 93, 1107, p. 20190873 1 p., 20190873.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chemotherapy 100%
  • Cellular Processes 100%
  • Proton Irradiation 100%
  • Neoplasm 100%
  • Weakness 100%
  66 Downloads (Pure)

• Μulti-institutional dosimetric delivery assessment of intracranial stereotactic radiosurgery on different treatment platforms

  Dimitriadis, A., Tsang, Y. M., Thomas, R., Palmer, A., Eaton, D., Lee, J., Patel, R., Silvestre Patallo, I., Gouldstone, C., Snaith, J., Kirkby, K., Nisbet, A. & Clark, C., 20 May 2020, In: Radiotherapy & Oncology. 147, p. 153-161

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Brainstem 100%
  • Alanine 100%
  • Cyberknife 66%
  195 Downloads (Pure)
• 2019

  A New Method to Reconstruct in 3D the Emission Position of the Prompt Gamma Rays following Proton Beam Irradiation

  Panaino, C., Mackay, R., Kirkby, K. & Taylor, M., 2019, In: Scientific Reports. 9, 18820.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proton Beam Therapy 100%
  • Beam Irradiation 100%
  • Gamma Ray 100%
  • Gamma Radiation 100%
  • Proton Beams 100%

• A new Standard DNA Damage (SDD) data format

  Warmenhoven, J., Henthorn, N., Kirkby, K., Merchant, M., Ingram, S. & et al., 2019, In: Radiation Research. 191, 1, p. 76-93

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Observables 100%
  • Data Format 100%
  • Endpoint 50%
  • Research Group 50%
  • Chemical Specie 50%

• Assessing localised dosimetric effects due to unplanned gas cavities during pelvic MR‐guided Radiotherapy using Monte Carlo simulations

  Shortall, J., Vasquez Osorio, E., Chuter, R., Mcwilliam, A., Choudhury, A., Kirkby, K., Mackay, R. & Van Herk, M., 2019, In: Medical Physics.

  Research output: Contribution to journal › Article › peer-review

  • Radiation Therapy 100%
  • Pelvis 100%
  • Monte Carlo Method 100%
  • Dose-Volume Histogram 25%
  • Treatment Planning 25%

• Clinically relevant nanodosimetric simulation of DNA damage complexity from photons and protons

  Henthorn, N., Warmenhoven, J., Sotiropoulos, M., Aitkenhead, A., Smith, E., Ingram, S., Kirkby, N., Chadwick, A., Burnet, N., Mackay, R., Kirkby, K. & Merchant, M., 2019, In: RSC Advances.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Applicability 100%
  • Endpoint 100%
  • Model Prediction 100%
  • Phenomenological Model 100%
  • Model Structure 100%

• Full 3D Position Reconstruction of a Radioactive Source Based on a Novel Hyperbolic Geometrical Algorithm

  Panaino, C., Mackay, R., Sotiropoulos, M., Kirkby, K. & Taylor, M., 26 Dec 2019, In: Computer Physics Communications. 252, 107131.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ray Source 100%
  • Proton Beam Therapy 100%
  • Detector Array 100%
  • Scintillation Detector 100%
  • Energy Detector 100%

• In Silico Models of DNA Damage and Repair in Proton Treatment Planning: A Proof of Concept

  Smith, E., Henthorn, N., Warmenhoven, J., Ingram, S., Aitkenhead, A., Richardson, J., Chadwick, A., Underwood, T., Merchant, M., Burnet, N., Kirkby, N., Kirkby, K. & Mackay, R., 27 Dec 2019, In: Scientific Reports.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Damage 100%
  • DNA Repair 100%
  • Linear Energy Transfer 100%
  • Computer Model 100%
  • Relative Biologic Effectiveness 100%

• Mechanistic modelling supports entwined rather than exclusively competitive DNA double-strand break repair pathway

  Ingram, S., Warmenhoven, J., Henthorn, N., Smith, E., Burnet, N., Mackay, R., Kirkby, N., Kirkby, K. & Merchant, M., 23 Apr 2019, In: Scientific Reports. 9, 1, p. 6359 6359.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Homologous Recombination 100%
  • Non-Homologous End Joining 100%
  • Experimental Data 100%
  • Concludes 50%
  • Rad50 25%

• Preclinical dosimetry: exploring the use of small animal phantoms

  Biglin, E. R., Price, G. J., Chadwick, A. L., Aitkenhead, A. H., Williams, K. J. & Kirkby, K. J., 2019, In: Radiation Oncology. 14, 1

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Radiation Therapy 100%
  • Dosimetry 100%
  • In Vitro 33%
  • Neoplasm 33%
• 2018

  An In Silico Model of DNA Repair for Investigation of Mechanisms in Non-Homologous End Joining

  Warmenhoven, J., Henthorn, N., Sotiropoulos, M., Korabel, N., Fedotov, S., Mackay, R., Kirkby, K. & Merchant, M., May 2018

  Research output: Other contribution › peer-review

• Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit

  Mcnamara, A. L., Ramos-méndez, J., Perl, J., Held, K., Dominguez, N., Moreno, E., Henthorn, N. T., Kirkby, K. J., Meylan, S., Villagrasa, C., Incerti, S., Faddegon, B., Paganetti, H. & Schuemann, J., 6 Sept 2018, In: Physics in Medicine and Biology. 63, 17, 175018.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Spatial Distribution 100%
  • Nanometre 100%
  • Powerful Tool 100%
  • Radiobiology 100%
  329 Downloads (Pure)

• In Silico Non-Homologous End Joining Following Ion Induced DNA Double Strand Breaks Predicts That Repair Fidelity Depends on Break Density

  Henthorn, N. (Lead), Warmenhoven, J. (Lead), Sotiropoulos, M., Mackay, R., Kirkby, N., Kirkby, K. & Merchant, M., 8 Feb 2018, In: Scientific Reports. 8, 1, p. 2654 2654.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • In Silico 100%
  • Non-Homologous End Joining 100%
  • Double Stranded DNA 100%
  • Ion Therapy 100%
  • Linear Energy Transfer 100%

• Mathematical Modelling for Patient Selection in Proton Therapy

  Mee, T., Kirkby, N. & Kirkby, K., 14 Feb 2018, In: Clinical Oncology. 30, 5, p. 299-306 8 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Proton Therapy 100%
  • Patient Selection 100%
  • Malignant Neoplasm 100%
  • Base 100%
  • Markov Chain 100%
  415 Downloads (Pure)

• Proton Beam Therapy - the Challenges of Delivering High-quality Evidence of Clinical Benefit

  National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) Proton Beam Clinical Trial Strategy Group & Kirkby, K., May 2018, In: Clinical oncology (Royal College of Radiologists (Great Britain)). 30, 5, p. 280-284 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Proton Therapy 100%
  • Radiation Therapy 75%
  • Health Care Cost 25%
  • Cancer Research 25%
• 2017

  Automated microbeam observation environment for biological analysis—Custom portable environmental control applied to a vertical microbeam system

  England, M. J., Bigelow, A. W., Merchant, M. J., Velliou, E., Welch, D., Brenner, D. J. & Kirkby, K. J., 1 Feb 2017, In: Sensors and Actuators, B: Chemical. 239, p. 1134-1143 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Incubator 100%
  • Environmental Control 100%
  • Relative Humidity 66%
  • Tasks 33%
  • Environmental Control System 33%

• Coupling Monte Carlo simulations with thermal analysis for correcting microdosimetric spectra from a novel micro-calorimeter

  Fathi, K., Galer, S., Kirkby, K., Palmans, H. & Nisbet, A., 2017, In: Radiation Physics and Chemistry.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Calorimeter 100%
  • Monte Carlo Simulation 100%
  • Specific Heat 100%
  • Thermal Analysis 100%
  • SQUID (Device) 100%
  1042 Downloads (Pure)

• Modelling direct DNA damage for gold nanoparticle enhanced proton therapy

  Sotiropoulos, M., Henthorn, N., Warmenhoven, J., Mackay, R., Kirkby, K. & Merchant, M., 2017, In: Nanoscale.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Damage 100%
  • Gold Nanoparticles 100%
  • Locale 100%
  • Nanoparticle 100%
  • Radiosensitization 83%

• Monte Carlo simulation of a TEPC for microdosimetry of carbon ions

  Galer, S., Shipley, D. R., Palmans, H., Kirkby, K. J. & Nisbet, A., 1 Nov 2017, In: Radiation Physics and Chemistry. 140, p. 412-418 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Proportional Counter 100%
  • Microdosimetry 100%
  • Ion Beams 100%
  • Monte Carlo Simulation 100%
  • Ion Beam 100%

• Nanodosimetric simulation of direct ion induced DNA damage using different chromatin geometry models

  Henthorn, N., Warmenhoven, J., Sotiropoulos, M., Mackay, R. I., Kirkby, K. & Merchant, M., Dec 2017, In: Radiation Research. 188, 6, p. 690-703 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Statistically Significant Difference 100%
  • Alpha Particle 100%
  • Cell Model 100%
  • Do Model 100%
  • Model Geometry 100%
• 2015

  Current status of cranial stereotactic raDiosurgery in the UK

  Dimitriadis, A., Kirkby, K. J., Nisbet, A. & Clark, C. H., 2015, In: British Journal of Radiology. 89, 1058, 20150452.

  Research output: Contribution to journal › Article › peer-review

  • Stereotactic Radiosurgery 100%
  • Radiation Therapy 22%
  • Vestibular Schwannoma 11%
  • Ionization Chamber 11%
  • Brain Metastasis 11%