HFSP _A bottom-up approach to understand how enzyme structural fluctuations accelerate multistep reactions

Status	Finished
Effective start/end date	1/09/22 → 31/08/25

Engineered enzymes for enantioselective nucleophilic aromatic substitutions
Lister, T. M., Roberts, G. W., Hossack, E. J., Zhao, F., Burke, A. J., Johannissen, L. O., Hardy, F. J., Millman, A. A. V., Leys, D., Larrosa, I. & Green, A. P., 13 Mar 2025, In: Nature. 639, p. 375–381
Research output: Contribution to journal › Article › peer-review

Open Access
Photosensitizer Repositioning Affords an Enantiocomplementary Enzyme for [2+2]‐Cycloadditions
Chuanjie, S., Kohn, A. R., Smithson, R., Hardy, F. J., Trimble, J. S., Cao, Y., Johannissen, L. O., Hay, S., Crawshaw, R. & Green, A. P., 27 Jun 2025, (E-pub ahead of print) In: Angewandte Chemie International Edition.
Research output: Contribution to journal › Article › peer-review
A non-canonical nucleophile unlocks a new mechanistic pathway in a designed enzyme
Hutton, A. E., Foster, J., Crawshaw, R., Hardy, F., Johannissen, L., Lister, T., Gerard, E., Birch - Price, Z., Obexer, R., Hay, S. & Green, A., 4 Mar 2024, In: Nature Communications. 15, 1956.
Research output: Contribution to journal › Article › peer-review

Open Access

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