Research output per year
Research output per year
- 20 results
Search results
-
2022
How a 10-epi-cubebol Synthase Avoids Premature Reaction Quenching to Form a Tricyclic Product at High Purity
Whitehead, J. N., Leferink, N. G. H., Komati Reddy, G., Levy, C. W., Hay, S., Takano, E. & Scrutton, N. S., 7 Oct 2022, In: ACS Catalysis. 12, 19, p. 12123–12131Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Taming the reactivity of monoterpene synthases to guide regioselective product hydroxylation
Leferink, N., Ranaghan, K. E., Battye, J., Johannissen, L., Hay, S., Kamp, M. W. V. D., Mulholland, A. J. & Scrutton, N., 2020, In: CHEMBIOCHEM. 20, p. 1-7 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Techno-economic assessment of microbial limonene production
Sun, C., Theodoropoulos, C. & Scrutton, N. S., 1 Mar 2020, In: Bioresource Technology. 300, p. 122666Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in Escherichia coli
Jervis, A. J., Carbonell, P., Vinaixa, M., Dunstan, M. S., Hollywood, K. A., Robinson, C. J., Rattray, N. J. W., Yan, C., Swainston, N., Currin, A., Sung, R., Toogood, H., Taylor, S., Faulon, J-L., Breitling, R., Takano, E. & Scrutton, N. S., 18 Jan 2019, In: ACS Synthetic Biology. 8, 1, p. 127-136 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2018
A Toolbox for Diverse Oxyfunctionalisation of Monoterpenes
Hernandez Ortega, A., Vinaixa, M., Zebec, Z., Takano, E. & Scrutton, N., 2018, In: Scientific Reports. 8, 14396.Research output: Contribution to journal › Article › peer-review
Open Access -
Biomolecular simulations: From dynamics and mechanisms to computational assays of biological activity
Huggins, D. J., Biggin, P. C., Dämgen, M. A., Essex, J. W., Harris, S. A., Henchman, R. H., Khalid, S., Kuzmanic, A., Laughton, C. A., Michel, J., Mulholland, A. J., Rosta, E., Sansom, M. S. P. & Van Der Kamp, M. W., 2018, In: Wiley Interdisciplinary Reviews: Computational Molecular Science.Research output: Contribution to journal › Article › peer-review
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Defining informative priors for ensemble modeling in systems biology
Tsigkinopoulou, A., Hawari, A., Uttley, M. & Breitling, R., 1 Nov 2018, In: Nature protocols. 13, 11, p. 2643-2663 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile35 Downloads (Pure) -
Experiment and Simulation Reveal How Mutations in Functional Plasticity Regions Guide Plant Monoterpene Synthase Product Outcome
Leferink, N., Ranaghan, K. E., Karuppiah, V., Currin, A., van der Camp, M. W., Mulholland, A. J. & Scrutton, N., 4 May 2018, In: ACS Catalysis. 8, 5, p. 3780-3791Research output: Contribution to journal › Article › peer-review
Open AccessFile122 Downloads (Pure) -
From bugs to bioplastics: Total (+)-dihydrocarvide biosynthesis by engineered Escherichia coli
Ascue Avalos, G., Toogood, H., Tait, S., Messiha, H. & Scrutton, N., 2018, In: ChemBioChem: a European journal of chemical biology .Research output: Contribution to journal › Article › peer-review
Open Access -
Genome Editing for the Production of Natural Products in Escherichia coli
Zebec, Z. & Scrutton, N. S., 1 Nov 2018, In: Advanced Biosystems. 2, 11, p. 1800056Research output: Contribution to journal › Review article › peer-review
Open AccessFile154 Downloads (Pure) -
2017
Ab Initio QM/MM Modeling of the Rate-Limiting Proton Transfer Step in the Deamination of Tryptamine by Aromatic Amine Dehydrogenase
Ranaghan, K. E., Morris, W. G., Masgrau, L., Senthilkumar, K., Johannissen, L. O., Scrutton, N. S., Harvey, J. N., Manby, F. R. & Mulholland, A. J., 2017, In: Journal of Physical Chemistry B. 121, 42, p. 9785-9798 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile110 Downloads (Pure) -
Structural basis of catalysis in the bacterial monoterpene synthases linalool synthase and 1,8-cineole synthase
Karuppiah, V., Ranaghan, K. E., Leferink, N., Johannissen, L., Shanmugam, M., Ni Cheallaigh, A., Bennett, N. J., Takano, E., Gardiner, J., van der Kamp, M. W., Hay, S., Mulholland, A. J., Leys, D. & Scrutton, N., 2017, In: ACS Catalysis.Research output: Contribution to journal › Article › peer-review
Open Access -
2016
A 'Plug and Play' Platform for the Production of Diverse Monoterpene Hydrocarbon Scaffolds in Escherichia coli
Leferink, N., Jervis, A., Zebec, Z., Toogood, H., Hay, S., Takano, E. & Scrutton, N., Jun 2016, In: ChemistrySelect . 1, 9, p. 1893-1896 4 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Bioinformatics for the synthetic biology of natural products: Integrating across the Design–Build–Test cycle
Carbonell, P., Currin, A., Jervis, A., Rattray, N., Swainston, N., Yan, C., Takano, E. & Breitling, R., 2016, In: Natural Product Reports. 33, p. 925-932Research output: Contribution to journal › Article › peer-review
Open Access -
Natural Product Biosynthesis in Escherichia coli: Mentha Monoterpenoids
Toogood, H., Tait, S., Jervis, A., Ni Cheallaigh, A., Humphreys, L., Takano, E., Gardiner, J. & Scrutton, N., 2016, Synthetic biology and metabolic engineering in plants and microbes Part A: metabolism in microbes. O'Connor, S. E. (ed.). Elsevier BV, p. 247-270 24 p. (Methods in enzymology; vol. 575).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Pinpointing a mechanistic switch between ketoreduction and ‘ene’-reduction in short chain dehydrogenases/reductases
Lygidakis, A., Karuppiah, V., Hoeven, R., Ni Cheallaigh, A., Leys, D., Gardiner, J., Toogood, H. & Scrutton, N., 8 Aug 2016, In: Angewandte Chemie. 55, 33, p. 9596-9600 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
SYNBIOCHEM - A SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals.
Carbonell, P., Currin, A., Dunstan, M., Fellows, D., Jervis, A., Rattray, N. J. W., Robinson, C. J., Swainston, N., Vinaixa, M., Williams, A., Yan, C., Barran, P., Breitling, R., Chen, G. G-Q., Faulon, J-L., Goble, C., Goodacre, R., Kell, D. B., Feuvre, R. L., Micklefield, J., & 4 others, 15 Jun 2016, In: Biochemical Society Transactions. 44, 3, p. 675-7Research output: Contribution to journal › Article › peer-review
Open Access -
Towards Synthesis of Monoterpenes and Derivatives Using Synthetic Biology
Zebec, Z., Wilkes, J., Jervis, A., Scrutton, N., Takano, E. & Breitling, R., 2016, In: Current Opinion in Chemical Biology. 34Research output: Contribution to journal › Article › peer-review
Open Access -
2015
Enzymatic Menthol Production: One-pot Approach Using Engineered Escherichia coli.
Toogood, H., Ni Cheallaigh, A., Tait, S., Mansell, D. J., Jervis, A., Lygidakis, A., Humphreys, L. D., Takano, E., Gardiner, J. & Scrutton, N. S., 27 May 2015, In: A C S Synthetic Biology.Research output: Contribution to journal › Article › peer-review
Open Access -
Judging synthetic biology risks
Breitling, R., Takano, E. & Gardner, TS., 9 Jan 2015, In: Science. 347, 6218, p. 107Research output: Contribution to journal › Article › peer-review