Targeting the Hippo Pathway to Control Adverse Cardiac Remodelling

Heart diseases such as long-term high blood pressure and heart attack can lead to changes in heart structure (heart remodelling). These changes may include enlargement of heart cells, formation of scar tissues and the death of heart muscle cells. This process may lead to worsening heart function and eventually the failure of the heart to pump blood adequately to the whole body (heart failure). We have identified molecules in the heart (Pontin, microRNA-411 and serotonin receptors) that may inhibit the remodelling process and prevent heart failure. These molecules work by regulating a network of proteins called the Hippo pathway. In this study, which is funded by BHF Programme Grant, we will investigate in detail how these molecules affect heart remodelling and will examine whether they can be used as therapeutic targets.