α7-Acetylcholine receptor antibodies in two patients with Rasmussen encephalitis

R. Watson; J. E C Jepson; I. Bermudez; S. Alexander; Y. Hart; K. McKnight; A. Roubertie; F. Fecto; J. Valmier; D. B. Sattelle; D. Beeson; A. Vincent; B. Lang

doi:10.1212/01.wnl.0000191566.86977.04

α7-Acetylcholine receptor antibodies in two patients with Rasmussen encephalitis

R. Watson, J. E C Jepson, I. Bermudez, S. Alexander, Y. Hart, K. McKnight, A. Roubertie, F. Fecto, J. Valmier, D. B. Sattelle, D. Beeson, A. Vincent, B. Lang

Research output: Contribution to journal › Article › peer-review

Abstract

Rasmussen encephalitis (RE) sera were screened for antibodies to human α7 nicotinic acetylcholine receptors (nAChRs) using electrophysiology, calcium imaging, and ligand binding assays. Sera from two of nine patients with RE blocked ACh-induced currents through α7 nAChRs and the ACh-induced rise in intracellular free calcium ([Ca2+]i) and inhibited 125I-α-bungarotoxin binding in cells expressing α7 nAChRs. Thus, the α7 nAChR is a potential target for pathogenic antibodies in patients with RE. Copyright © 2005 by AAN Enterprises, Inc.

Original language	English
Pages (from-to)	1802-1804
Number of pages	2
Journal	Neurology
Volume	65
Issue number	11
DOIs	https://doi.org/10.1212/01.wnl.0000191566.86977.04
Publication status	Published - Dec 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1212/01.wnl.0000191566.86977.04

Cite this

@article{d9b3f0fa6ad34fc4b3afde5830f8fc84,

title = "α7-Acetylcholine receptor antibodies in two patients with Rasmussen encephalitis",

abstract = "Rasmussen encephalitis (RE) sera were screened for antibodies to human α7 nicotinic acetylcholine receptors (nAChRs) using electrophysiology, calcium imaging, and ligand binding assays. Sera from two of nine patients with RE blocked ACh-induced currents through α7 nAChRs and the ACh-induced rise in intracellular free calcium ([Ca2+]i) and inhibited 125I-α-bungarotoxin binding in cells expressing α7 nAChRs. Thus, the α7 nAChR is a potential target for pathogenic antibodies in patients with RE. Copyright {\textcopyright} 2005 by AAN Enterprises, Inc.",

author = "R. Watson and Jepson, {J. E C} and I. Bermudez and S. Alexander and Y. Hart and K. McKnight and A. Roubertie and F. Fecto and J. Valmier and Sattelle, {D. B.} and D. Beeson and A. Vincent and B. Lang",

note = ", Wellcome Trust, United Kingdom",

year = "2005",

month = dec,

doi = "10.1212/01.wnl.0000191566.86977.04",

language = "English",

volume = "65",

pages = "1802--1804",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams & Wilkins",

number = "11",

}

TY - JOUR

T1 - α7-Acetylcholine receptor antibodies in two patients with Rasmussen encephalitis

AU - Watson, R.

AU - Jepson, J. E C

AU - Bermudez, I.

AU - Alexander, S.

AU - Hart, Y.

AU - McKnight, K.

AU - Roubertie, A.

AU - Fecto, F.

AU - Valmier, J.

AU - Sattelle, D. B.

AU - Beeson, D.

AU - Vincent, A.

AU - Lang, B.

N1 - , Wellcome Trust, United Kingdom

PY - 2005/12

Y1 - 2005/12

N2 - Rasmussen encephalitis (RE) sera were screened for antibodies to human α7 nicotinic acetylcholine receptors (nAChRs) using electrophysiology, calcium imaging, and ligand binding assays. Sera from two of nine patients with RE blocked ACh-induced currents through α7 nAChRs and the ACh-induced rise in intracellular free calcium ([Ca2+]i) and inhibited 125I-α-bungarotoxin binding in cells expressing α7 nAChRs. Thus, the α7 nAChR is a potential target for pathogenic antibodies in patients with RE. Copyright © 2005 by AAN Enterprises, Inc.

AB - Rasmussen encephalitis (RE) sera were screened for antibodies to human α7 nicotinic acetylcholine receptors (nAChRs) using electrophysiology, calcium imaging, and ligand binding assays. Sera from two of nine patients with RE blocked ACh-induced currents through α7 nAChRs and the ACh-induced rise in intracellular free calcium ([Ca2+]i) and inhibited 125I-α-bungarotoxin binding in cells expressing α7 nAChRs. Thus, the α7 nAChR is a potential target for pathogenic antibodies in patients with RE. Copyright © 2005 by AAN Enterprises, Inc.

U2 - 10.1212/01.wnl.0000191566.86977.04

DO - 10.1212/01.wnl.0000191566.86977.04

M3 - Article

C2 - 16344526

SN - 0028-3878

VL - 65

SP - 1802

EP - 1804

JO - Neurology

JF - Neurology

IS - 11

ER -

α7-Acetylcholine receptor antibodies in two patients with Rasmussen encephalitis

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this