β-Carotene with vitamins E and C offers synergistic cell protection against NO(x)

F. Böhm, R. Edge, D. J. McGarvey, T. G. Truscott

Research output: Contribution to journalArticlepeer-review

Abstract

The peroxynitrite anion and the nitrogen dioxide (radical) are important toxic species which can arise in vivo from nitric oxide. Both in vivo and in vitro cell protection is demonstrated for β-carotene in the presence of vitamin E and vitamin C. A synergistic protection is observed compared to the individual anti-oxidants and this is explained in terms of an electron transfer reaction in which the β-carotene radical is repaired by vitamin C. Copyright (C) 1998 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)387-389
Number of pages3
JournalFEBS Letters
Volume436
Issue number3
DOIs
Publication statusPublished - 9 Oct 1998

Keywords

  • β-Carotene
  • Lymphocyte
  • Nitrogen dioxide
  • Peroxynitrite
  • Vitamin C
  • Vitamin E

Research Beacons, Institutes and Platforms

  • Dalton Nuclear Institute

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