β Integrins Mediate FAK Y397 Autophosphorylation of Resistance Arteries during Eutrophic Inward Remodeling in Hypertension

E Heerkens; L Quinn; S Withers; A Heagerty

doi:10.1159/000365479

β Integrins Mediate FAK Y397 Autophosphorylation of Resistance Arteries during Eutrophic Inward Remodeling in Hypertension

E Heerkens, L Quinn, S Withers, A Heagerty

Research output: Contribution to journal › Article › peer-review

196 Downloads (Pure)

Abstract

Human essential hypertension is characterized by eutrophic inward remodeling of resistance arteries with little evidence of hypertrophy. Upregulation of ÃŽÂ±VÃŽÂ²3 integrin is crucial during this process. In order to investigate the role of focal adhesion kinase activation in this process, the level of FAK Y397 autophosphorylation was studied in small blood vessels from young TGR(mRen2)27 animals as blood pressure rose and eutrophic inward remodeling took place. Between weeks 4 and 5 this process was completed and accompanied by a significant increase in FAK phosphorylation compared with normotensive control animals. Phosphorylated-FAK Y397 was immuno-co-precipitated with both Ã¯Â�Â¢1 and Ã¯Â�Â¢3 integrin specific antibodies. In contrast, only a fraction (

Original language	English
Pages (from-to)	305-314
Journal	Journal of Vascular Research
Volume	51
Issue number	4
DOIs	https://doi.org/10.1159/000365479
Publication status	Published - 2014

Keywords

integrins, resistance arteries, eutrophic remodeling, hypertension

Access to Document

10.1159/000365479

POST-PEER-REVIEW-NON-PUBLISHERS.PDFAccepted author manuscript, 273 KBLicence: CC BY
SUPPLEMENTARY-1

Cite this

@article{2bcbe063b089485cb5c5047633d04f1b,

title = "β Integrins Mediate FAK Y397 Autophosphorylation of Resistance Arteries during Eutrophic Inward Remodeling in Hypertension",

abstract = "Human essential hypertension is characterized by eutrophic inward remodeling of resistance arteries with little evidence of hypertrophy. Upregulation of {\~A}{\v Z}{\^A}±V{\~A}{\v Z}{\^A}²3 integrin is crucial during this process. In order to investigate the role of focal adhesion kinase activation in this process, the level of FAK Y397 autophosphorylation was studied in small blood vessels from young TGR(mRen2)27 animals as blood pressure rose and eutrophic inward remodeling took place. Between weeks 4 and 5 this process was completed and accompanied by a significant increase in FAK phosphorylation compared with normotensive control animals. Phosphorylated-FAK Y397 was immuno-co-precipitated with both {\~A}¯{\^A}�{\^A}¢1 and {\~A}¯{\^A}�{\^A}¢3 integrin specific antibodies. In contrast, only a fraction (",

keywords = "integrins, resistance arteries, eutrophic remodeling, hypertension",

author = "E Heerkens and L Quinn and S Withers and A Heagerty",

year = "2014",

doi = "10.1159/000365479",

language = "English",

volume = "51",

pages = "305--314",

journal = "Journal of Vascular Research",

issn = "1018-1172",

publisher = "S. Karger AG",

number = "4",

}

TY - JOUR

T1 - β Integrins Mediate FAK Y397 Autophosphorylation of Resistance Arteries during Eutrophic Inward Remodeling in Hypertension

AU - Heerkens, E

AU - Quinn, L

AU - Withers, S

AU - Heagerty, A

PY - 2014

Y1 - 2014

N2 - Human essential hypertension is characterized by eutrophic inward remodeling of resistance arteries with little evidence of hypertrophy. Upregulation of ÃŽÂ±VÃŽÂ²3 integrin is crucial during this process. In order to investigate the role of focal adhesion kinase activation in this process, the level of FAK Y397 autophosphorylation was studied in small blood vessels from young TGR(mRen2)27 animals as blood pressure rose and eutrophic inward remodeling took place. Between weeks 4 and 5 this process was completed and accompanied by a significant increase in FAK phosphorylation compared with normotensive control animals. Phosphorylated-FAK Y397 was immuno-co-precipitated with both Ã¯Â�Â¢1 and Ã¯Â�Â¢3 integrin specific antibodies. In contrast, only a fraction (

AB - Human essential hypertension is characterized by eutrophic inward remodeling of resistance arteries with little evidence of hypertrophy. Upregulation of ÃŽÂ±VÃŽÂ²3 integrin is crucial during this process. In order to investigate the role of focal adhesion kinase activation in this process, the level of FAK Y397 autophosphorylation was studied in small blood vessels from young TGR(mRen2)27 animals as blood pressure rose and eutrophic inward remodeling took place. Between weeks 4 and 5 this process was completed and accompanied by a significant increase in FAK phosphorylation compared with normotensive control animals. Phosphorylated-FAK Y397 was immuno-co-precipitated with both Ã¯Â�Â¢1 and Ã¯Â�Â¢3 integrin specific antibodies. In contrast, only a fraction (

KW - integrins, resistance arteries, eutrophic remodeling, hypertension

U2 - 10.1159/000365479

DO - 10.1159/000365479

M3 - Article

SN - 1018-1172

VL - 51

SP - 305

EP - 314

JO - Journal of Vascular Research

JF - Journal of Vascular Research

IS - 4

ER -

β Integrins Mediate FAK Y397 Autophosphorylation of Resistance Arteries during Eutrophic Inward Remodeling in Hypertension

Abstract

Keywords

Access to Document

Fingerprint

Cite this