11q13 is a susceptibility locus for hormone receptor positive breast cancer

D Lambrechts; T Truong; C Justenhoven; M K Humphreys; J Wang; J L Hopper; G S Dite; C Apicella; M K Schmidt; A Broeks; S Cornelissen; R van Hien; E Sawyer; I Tomlinson; M Kerin; N Miller; R L Milne; M P Zamora; J I Perez; J Benitez; U Hamann; Y D Ko; T Bruning; J Chang-Claude; U Eilber; R Hein; S Nickels; D Flesch-Janys; S Wang-Gohrke; E M John; A Miron; R Winqvist; K Pylkas; A Jukkola-Vuorinen; M Grip; G Chenevix-Trench; J Beesley; X Chen; F Menegaux; E Cordina-Duverger; C Y Shen; J C Yu; P E Wu; M F Hou; I L Andrulis; T Selander; G Glendon; A M Mulligan; H Anton-Culver; A Ziogas; K R Muir; A Lophatananon; S Rattanamongkongul; P Puttawibul; M Jones; N Orr; A Ashworth; A Swerdlow; G Severi; L Baglietto; G Giles; M Southey; F Marme; A Schneeweiss; C Sohn; B Burwinkel; B T Yesilyurt; P Neven; R Paridaens; H Wildiers; H Brenner; H Muller; V Arndt; C Stegmaier; A Meindl; S Schott; C R Bartram; R K Schmutzler; A Cox; I W Brock; G Elliott; S S Cross; P A Fasching; R Schulz-Wendtland; A B Ekici; M W Beckmann; O Fletcher; N Johnson; S Silva Idos; J Peto; H Nevanlinna; T A Muranen; K Aittomaki; C Blomqvist; T Dork; P Schurmann; M Bremer; P Hillemanns; N V Bogdanova; N N Antonenkova; Y I Rogov; J H Karstens; E Khusnutdinova; M Bermisheva; D Prokofieva; S Gancev; A Jakubowska; J Lubinski; K Jaworska; K Durda; B G Nordestgaard; S E Bojesen; C Lanng; A Mannermaa; V Kataja; V M Kosma; J M Hartikainen; P Radice; P Peterlongo; S Manoukian; L Bernard; F J Couch; J E Olson; X Wang; Z Fredericksen; G G Alnaes; V Kristensen; A L Borresen-Dale; P Devilee; R A Tollenaar; C M Seynaeve; M J Hooning; M Garcia-Closas; S J Chanock; J Lissowska; M E Sherman; P Hall; J Liu; K Czene; D Kang; K Y Yoo; D Y Noh; A Lindblom; S Margolin; A M Dunning; P D Pharoah; D F Easton; P Guenel; H Brauch

doi:10.1002/humu.22089

11q13 is a susceptibility locus for hormone receptor positive breast cancer

D Lambrechts, T Truong, C Justenhoven, M K Humphreys, J Wang, J L Hopper, G S Dite, C Apicella, M K Schmidt, A Broeks, S Cornelissen, R van Hien, E Sawyer, I Tomlinson, M Kerin, N Miller, R L Milne, M P Zamora, J I Perez, J BenitezU Hamann, Y D Ko, T Bruning, J Chang-Claude, U Eilber, R Hein, S Nickels, D Flesch-Janys, S Wang-Gohrke, E M John, A Miron, R Winqvist, K Pylkas, A Jukkola-Vuorinen, M Grip, G Chenevix-Trench, J Beesley, X Chen, F Menegaux, E Cordina-Duverger, C Y Shen, J C Yu, P E Wu, M F Hou, I L Andrulis, T Selander, G Glendon, A M Mulligan, H Anton-Culver, A Ziogas, K R Muir, A Lophatananon, S Rattanamongkongul, P Puttawibul, M Jones, N Orr, A Ashworth, A Swerdlow, G Severi, L Baglietto, G Giles, M Southey, F Marme, A Schneeweiss, C Sohn, B Burwinkel, B T Yesilyurt, P Neven, R Paridaens, H Wildiers, H Brenner, H Muller, V Arndt, C Stegmaier, A Meindl, S Schott, C R Bartram, R K Schmutzler, A Cox, I W Brock, G Elliott, S S Cross, P A Fasching, R Schulz-Wendtland, A B Ekici, M W Beckmann, O Fletcher, N Johnson, S Silva Idos, J Peto, H Nevanlinna, T A Muranen, K Aittomaki, C Blomqvist, T Dork, P Schurmann, M Bremer, P Hillemanns, N V Bogdanova, N N Antonenkova, Y I Rogov, J H Karstens, E Khusnutdinova, M Bermisheva, D Prokofieva, S Gancev, A Jakubowska, J Lubinski, K Jaworska, K Durda, B G Nordestgaard, S E Bojesen, C Lanng, A Mannermaa, V Kataja, V M Kosma, J M Hartikainen, P Radice, P Peterlongo, S Manoukian, L Bernard, F J Couch, J E Olson, X Wang, Z Fredericksen, G G Alnaes, V Kristensen, A L Borresen-Dale, P Devilee, R A Tollenaar, C M Seynaeve, M J Hooning, M Garcia-Closas, S J Chanock, J Lissowska, M E Sherman, P Hall, J Liu, K Czene, D Kang, K Y Yoo, D Y Noh, A Lindblom, S Margolin, A M Dunning, P D Pharoah, D F Easton, P Guenel, H Brauch

Research output: Contribution to journal › Article › peer-review

Abstract

A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P

Original language	English
Pages (from-to)	1123-32
Number of pages	1090
Journal	Hum Mutat
Volume	33
Issue number	7
DOIs	https://doi.org/10.1002/humu.22089
Publication status	Published - 2012

Keywords

Breast Neoplasms/ genetics
Chromosomes, Human, Pair 11/ genetics
European Continental Ancestry Group
Female
Genetic Predisposition to Disease/genetics
Genome-Wide Association Study
Genotype
Humans
Polymorphism, Single Nucleotide/genetics
Receptors, Estrogen/ genetics
Receptors, Progesterone/ genetics
Risk Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/humu.22089

Cite this

Lambrechts, D., Truong, T., Justenhoven, C., Humphreys, M. K., Wang, J., Hopper, J. L., Dite, G. S., Apicella, C., Schmidt, M. K., Broeks, A., Cornelissen, S., van Hien, R., Sawyer, E., Tomlinson, I., Kerin, M., Miller, N., Milne, R. L., Zamora, M. P., Perez, J. I., ... Brauch, H. (2012). 11q13 is a susceptibility locus for hormone receptor positive breast cancer. Hum Mutat, 33(7), 1123-32. https://doi.org/10.1002/humu.22089

@article{200d76c2f6d249efaa2751b0599d7700,

title = "11q13 is a susceptibility locus for hormone receptor positive breast cancer",

abstract = "A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P",

keywords = "Breast Neoplasms/ genetics, Chromosomes, Human, Pair 11/ genetics, European Continental Ancestry Group, Female, Genetic Predisposition to Disease/genetics, Genome-Wide Association Study, Genotype, Humans, Polymorphism, Single Nucleotide/genetics, Receptors, Estrogen/ genetics, Receptors, Progesterone/ genetics, Risk Factors",

author = "D Lambrechts and T Truong and C Justenhoven and Humphreys, {M K} and J Wang and Hopper, {J L} and Dite, {G S} and C Apicella and Schmidt, {M K} and A Broeks and S Cornelissen and {van Hien}, R and E Sawyer and I Tomlinson and M Kerin and N Miller and Milne, {R L} and Zamora, {M P} and Perez, {J I} and J Benitez and U Hamann and Ko, {Y D} and T Bruning and J Chang-Claude and U Eilber and R Hein and S Nickels and D Flesch-Janys and S Wang-Gohrke and John, {E M} and A Miron and R Winqvist and K Pylkas and A Jukkola-Vuorinen and M Grip and G Chenevix-Trench and J Beesley and X Chen and F Menegaux and E Cordina-Duverger and Shen, {C Y} and Yu, {J C} and Wu, {P E} and Hou, {M F} and Andrulis, {I L} and T Selander and G Glendon and Mulligan, {A M} and H Anton-Culver and A Ziogas and Muir, {K R} and A Lophatananon and S Rattanamongkongul and P Puttawibul and M Jones and N Orr and A Ashworth and A Swerdlow and G Severi and L Baglietto and G Giles and M Southey and F Marme and A Schneeweiss and C Sohn and B Burwinkel and Yesilyurt, {B T} and P Neven and R Paridaens and H Wildiers and H Brenner and H Muller and V Arndt and C Stegmaier and A Meindl and S Schott and Bartram, {C R} and Schmutzler, {R K} and A Cox and Brock, {I W} and G Elliott and Cross, {S S} and Fasching, {P A} and R Schulz-Wendtland and Ekici, {A B} and Beckmann, {M W} and O Fletcher and N Johnson and {Silva Idos}, S and J Peto and H Nevanlinna and Muranen, {T A} and K Aittomaki and C Blomqvist and T Dork and P Schurmann and M Bremer and P Hillemanns and Bogdanova, {N V} and Antonenkova, {N N} and Rogov, {Y I} and Karstens, {J H} and E Khusnutdinova and M Bermisheva and D Prokofieva and S Gancev and A Jakubowska and J Lubinski and K Jaworska and K Durda and Nordestgaard, {B G} and Bojesen, {S E} and C Lanng and A Mannermaa and V Kataja and Kosma, {V M} and Hartikainen, {J M} and P Radice and P Peterlongo and S Manoukian and L Bernard and Couch, {F J} and Olson, {J E} and X Wang and Z Fredericksen and Alnaes, {G G} and V Kristensen and Borresen-Dale, {A L} and P Devilee and Tollenaar, {R A} and Seynaeve, {C M} and Hooning, {M J} and M Garcia-Closas and Chanock, {S J} and J Lissowska and Sherman, {M E} and P Hall and J Liu and K Czene and D Kang and Yoo, {K Y} and Noh, {D Y} and A Lindblom and S Margolin and Dunning, {A M} and Pharoah, {P D} and Easton, {D F} and P Guenel and H Brauch",

note = "Lambrechts, Diether Truong, Therese Justenhoven, Christina Humphreys, Manjeet K Wang, Jean Hopper, John L Dite, Gillian S Apicella, Carmel Southey, Melissa C Schmidt, Marjanka K Broeks, Annegien Cornelissen, Sten van Hien, Richard Sawyer, Elinor Tomlinson, Ian Kerin, Michael Miller, Nicola Milne, Roger L Zamora, M Pilar Perez, Jose Ignacio Arias Benitez, Javier Hamann, Ute Ko, Yon-Dschun Bruning, Thomas GENICA Network Chang-Claude, Jenny Eilber, Ursel Hein, Rebecca Nickels, Stefan Flesch-Janys, Dieter Wang-Gohrke, Shan John, Esther M Miron, Alexander Winqvist, Robert Pylkas, Katri Jukkola-Vuorinen, Arja Grip, Mervi Chenevix-Trench, Georgia Beesley, Jonathan Chen, Xiaoqing Investigators kConFab Australian Ovarian Cancer Study Group Menegaux, Florence Cordina-Duverger, Emilie Shen, Chen-Yang Yu, Jyh-Cherng Wu, Pei-Ei Hou, Ming-Feng Andrulis, Irene L Selander, Teresa Glendon, Gord Mulligan, Anna Marie Anton-Culver, Hoda Ziogas, Argyrios Muir, Kenneth R Lophatananon, Artitaya Rattanamongkongul, Suthee Puttawibul, Puttisak Jones, Michael Orr, Nicholas Ashworth, Alan Swerdlow, Anthony Severi, Gianluca Baglietto, Laura Giles, Graham Southey, Melissa Marme, Federik Schneeweiss, Andreas Sohn, Christof Burwinkel, Barbara Yesilyurt, Betul T Neven, Patrick Paridaens, Robert Wildiers, Hans Brenner, Hermann Muller, Heiko Arndt, Volker Stegmaier, Christa Meindl, Alfons Schott, Sarah Bartram, Claus R Schmutzler, Rita K Cox, Angela Brock, Ian W Elliott, Graeme Cross, Simon S Fasching, Peter A Schulz-Wendtland, Ruediger Ekici, Arif B Beckmann, Matthias W Fletcher, Olivia Johnson, Nichola Silva, Isabel Dos Santos Peto, Julian Nevanlinna, Heli Muranen, Taru A Aittomaki, Kristiina Blomqvist, Carl Dork, Thilo Schurmann, Peter Bremer, Michael Hillemanns, Peter Bogdanova, Natalia V Antonenkova, Natalia N Rogov, Yuri I Karstens, Johann H Khusnutdinova, Elza Bermisheva, Marina Prokofieva, Darya Gancev, Shamil Jakubowska, Anna Lubinski, Jan Jaworska, Katarzyna Durda, Katarzyna Nordestgaard, Borge G Bojesen, Stig E Lanng, Charlotte Mannermaa, Arto Kataja, Vesa Kosma, Veli-Matti Hartikainen, Jaana M Radice, Paolo Peterlongo, Paolo Manoukian, Siranoush Bernard, Loris Couch, Fergus J Olson, Janet E Wang, Xianshu Fredericksen, Zachary Alnaes, Grethe Grenaker Kristensen, Vessela Borresen-Dale, Anne-Lise Devilee, Peter Tollenaar, Robert A E M Seynaeve, Caroline M Hooning, Maartje J Garcia-Closas, Montserrat Chanock, Stephen J Lissowska, Jolanta Sherman, Mark E Hall, Per Liu, Jianjun Czene, Kamila Kang, Daehee Yoo, Keun-Young Noh, Dong-Young Lindblom, Annika Margolin, Sara Dunning, Alison M Pharoah, Paul D P Easton, Douglas F Guenel, Pascal Brauch, Hiltrud C1287/A10118/Cancer Research UK/United Kingdom C1287/A12014/Cancer Research UK/United Kingdom CA116201/CA/NCI NIH HHS/United States CA122340/CA/NCI NIH HHS/United States CA128978/CA/NCI NIH HHS/United States CA58860/CA/NCI NIH HHS/United States CA92044/CA/NCI NIH HHS/United States R01 CA122340-01A1/CA/NCI NIH HHS/United States R01 CA122340-02/CA/NCI NIH HHS/United States R01 CA122340-03/CA/NCI NIH HHS/United States R01 CA122340-03S1/CA/NCI NIH HHS/United States R01 CA122340-04/CA/NCI NIH HHS/United States R01 CA122340-05/CA/NCI NIH HHS/United States R01 CA128978-01A2/CA/NCI NIH HHS/United States R01 CA128978-02/CA/NCI NIH HHS/United States R01 CA128978-03/CA/NCI NIH HHS/United States R01 CA128978-04/CA/NCI NIH HHS/United States R01 CA128978-05/CA/NCI NIH HHS/United States U01 CA 69638/CA/NCI NIH HHS/United States U01 CA069417-10/CA/NCI NIH HHS/United States U01 CA069417-11/CA/NCI NIH HHS/United States U01 CA069417-11S1/CA/NCI NIH HHS/United States U01 CA069417-12/CA/NCI NIH HHS/United States U01 CA069417-13/CA/NCI NIH HHS/United States U01 CA069417-14/CA/NCI NIH HHS/United States U01 CA069417-15/CA/NCI NIH HHS/United States U01 CA069417-15S1/CA/NCI NIH HHS/United States U01 CA069417-16/CA/NCI NIH HHS/United States U01 CA69417/CA/NCI NIH HHS/United States U01 CA69467/CA/NCI NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. United States Human mutation Nihms364885 Hum Mutat. 2012 Jul;33(7):1123-32. doi: 10.1002/humu.22089. Epub 2012 Apr 30.",

year = "2012",

doi = "10.1002/humu.22089",

language = "English",

volume = "33",

pages = "1123--32",

journal = "Hum Mutat",

issn = "1098-1004",

publisher = "John Wiley & Sons Ltd",

number = "7",

}

Lambrechts, D, Truong, T, Justenhoven, C, Humphreys, MK, Wang, J, Hopper, JL, Dite, GS, Apicella, C, Schmidt, MK, Broeks, A, Cornelissen, S, van Hien, R, Sawyer, E, Tomlinson, I, Kerin, M, Miller, N, Milne, RL, Zamora, MP, Perez, JI, Benitez, J, Hamann, U, Ko, YD, Bruning, T, Chang-Claude, J, Eilber, U, Hein, R, Nickels, S, Flesch-Janys, D, Wang-Gohrke, S, John, EM, Miron, A, Winqvist, R, Pylkas, K, Jukkola-Vuorinen, A, Grip, M, Chenevix-Trench, G, Beesley, J, Chen, X, Menegaux, F, Cordina-Duverger, E, Shen, CY, Yu, JC, Wu, PE, Hou, MF, Andrulis, IL, Selander, T, Glendon, G, Mulligan, AM, Anton-Culver, H, Ziogas, A, Muir, KR, Lophatananon, A, Rattanamongkongul, S, Puttawibul, P, Jones, M, Orr, N, Ashworth, A, Swerdlow, A, Severi, G, Baglietto, L, Giles, G, Southey, M, Marme, F, Schneeweiss, A, Sohn, C, Burwinkel, B, Yesilyurt, BT, Neven, P, Paridaens, R, Wildiers, H, Brenner, H, Muller, H, Arndt, V, Stegmaier, C, Meindl, A, Schott, S, Bartram, CR, Schmutzler, RK, Cox, A, Brock, IW, Elliott, G, Cross, SS, Fasching, PA, Schulz-Wendtland, R, Ekici, AB, Beckmann, MW, Fletcher, O, Johnson, N, Silva Idos, S, Peto, J, Nevanlinna, H, Muranen, TA, Aittomaki, K, Blomqvist, C, Dork, T, Schurmann, P, Bremer, M, Hillemanns, P, Bogdanova, NV, Antonenkova, NN, Rogov, YI, Karstens, JH, Khusnutdinova, E, Bermisheva, M, Prokofieva, D, Gancev, S, Jakubowska, A, Lubinski, J, Jaworska, K, Durda, K, Nordestgaard, BG, Bojesen, SE, Lanng, C, Mannermaa, A, Kataja, V, Kosma, VM, Hartikainen, JM, Radice, P, Peterlongo, P, Manoukian, S, Bernard, L, Couch, FJ, Olson, JE, Wang, X, Fredericksen, Z, Alnaes, GG, Kristensen, V, Borresen-Dale, AL, Devilee, P, Tollenaar, RA, Seynaeve, CM, Hooning, MJ, Garcia-Closas, M, Chanock, SJ, Lissowska, J, Sherman, ME, Hall, P, Liu, J, Czene, K, Kang, D, Yoo, KY, Noh, DY, Lindblom, A, Margolin, S, Dunning, AM, Pharoah, PD, Easton, DF, Guenel, P & Brauch, H 2012, '11q13 is a susceptibility locus for hormone receptor positive breast cancer', Hum Mutat, vol. 33, no. 7, pp. 1123-32. https://doi.org/10.1002/humu.22089

TY - JOUR

T1 - 11q13 is a susceptibility locus for hormone receptor positive breast cancer

AU - Lambrechts, D

AU - Truong, T

AU - Justenhoven, C

AU - Humphreys, M K

AU - Wang, J

AU - Hopper, J L

AU - Dite, G S

AU - Apicella, C

AU - Schmidt, M K

AU - Broeks, A

AU - Cornelissen, S

AU - van Hien, R

AU - Sawyer, E

AU - Tomlinson, I

AU - Kerin, M

AU - Miller, N

AU - Milne, R L

AU - Zamora, M P

AU - Perez, J I

AU - Benitez, J

AU - Hamann, U

AU - Ko, Y D

AU - Bruning, T

AU - Chang-Claude, J

AU - Eilber, U

AU - Hein, R

AU - Nickels, S

AU - Flesch-Janys, D

AU - Wang-Gohrke, S

AU - John, E M

AU - Miron, A

AU - Winqvist, R

AU - Pylkas, K

AU - Jukkola-Vuorinen, A

AU - Grip, M

AU - Chenevix-Trench, G

AU - Beesley, J

AU - Chen, X

AU - Menegaux, F

AU - Cordina-Duverger, E

AU - Shen, C Y

AU - Yu, J C

AU - Wu, P E

AU - Hou, M F

AU - Andrulis, I L

AU - Selander, T

AU - Glendon, G

AU - Mulligan, A M

AU - Anton-Culver, H

AU - Ziogas, A

AU - Muir, K R

AU - Lophatananon, A

AU - Rattanamongkongul, S

AU - Puttawibul, P

AU - Jones, M

AU - Orr, N

AU - Ashworth, A

AU - Swerdlow, A

AU - Severi, G

AU - Baglietto, L

AU - Giles, G

AU - Southey, M

AU - Marme, F

AU - Schneeweiss, A

AU - Sohn, C

AU - Burwinkel, B

AU - Yesilyurt, B T

AU - Neven, P

AU - Paridaens, R

AU - Wildiers, H

AU - Brenner, H

AU - Muller, H

AU - Arndt, V

AU - Stegmaier, C

AU - Meindl, A

AU - Schott, S

AU - Bartram, C R

AU - Schmutzler, R K

AU - Cox, A

AU - Brock, I W

AU - Elliott, G

AU - Cross, S S

AU - Fasching, P A

AU - Schulz-Wendtland, R

AU - Ekici, A B

AU - Beckmann, M W

AU - Fletcher, O

AU - Johnson, N

AU - Silva Idos, S

AU - Peto, J

AU - Nevanlinna, H

AU - Muranen, T A

AU - Aittomaki, K

AU - Blomqvist, C

AU - Dork, T

AU - Schurmann, P

AU - Bremer, M

AU - Hillemanns, P

AU - Bogdanova, N V

AU - Antonenkova, N N

AU - Rogov, Y I

AU - Karstens, J H

AU - Khusnutdinova, E

AU - Bermisheva, M

AU - Prokofieva, D

AU - Gancev, S

AU - Jakubowska, A

AU - Lubinski, J

AU - Jaworska, K

AU - Durda, K

AU - Nordestgaard, B G

AU - Bojesen, S E

AU - Lanng, C

AU - Mannermaa, A

AU - Kataja, V

AU - Kosma, V M

AU - Hartikainen, J M

AU - Radice, P

AU - Peterlongo, P

AU - Manoukian, S

AU - Bernard, L

AU - Couch, F J

AU - Olson, J E

AU - Wang, X

AU - Fredericksen, Z

AU - Alnaes, G G

AU - Kristensen, V

AU - Borresen-Dale, A L

AU - Devilee, P

AU - Tollenaar, R A

AU - Seynaeve, C M

AU - Hooning, M J

AU - Garcia-Closas, M

AU - Chanock, S J

AU - Lissowska, J

AU - Sherman, M E

AU - Hall, P

AU - Liu, J

AU - Czene, K

AU - Kang, D

AU - Yoo, K Y

AU - Noh, D Y

AU - Lindblom, A

AU - Margolin, S

AU - Dunning, A M

AU - Pharoah, P D

AU - Easton, D F

AU - Guenel, P

AU - Brauch, H

N1 - Lambrechts, Diether Truong, Therese Justenhoven, Christina Humphreys, Manjeet K Wang, Jean Hopper, John L Dite, Gillian S Apicella, Carmel Southey, Melissa C Schmidt, Marjanka K Broeks, Annegien Cornelissen, Sten van Hien, Richard Sawyer, Elinor Tomlinson, Ian Kerin, Michael Miller, Nicola Milne, Roger L Zamora, M Pilar Perez, Jose Ignacio Arias Benitez, Javier Hamann, Ute Ko, Yon-Dschun Bruning, Thomas GENICA Network Chang-Claude, Jenny Eilber, Ursel Hein, Rebecca Nickels, Stefan Flesch-Janys, Dieter Wang-Gohrke, Shan John, Esther M Miron, Alexander Winqvist, Robert Pylkas, Katri Jukkola-Vuorinen, Arja Grip, Mervi Chenevix-Trench, Georgia Beesley, Jonathan Chen, Xiaoqing Investigators kConFab Australian Ovarian Cancer Study Group Menegaux, Florence Cordina-Duverger, Emilie Shen, Chen-Yang Yu, Jyh-Cherng Wu, Pei-Ei Hou, Ming-Feng Andrulis, Irene L Selander, Teresa Glendon, Gord Mulligan, Anna Marie Anton-Culver, Hoda Ziogas, Argyrios Muir, Kenneth R Lophatananon, Artitaya Rattanamongkongul, Suthee Puttawibul, Puttisak Jones, Michael Orr, Nicholas Ashworth, Alan Swerdlow, Anthony Severi, Gianluca Baglietto, Laura Giles, Graham Southey, Melissa Marme, Federik Schneeweiss, Andreas Sohn, Christof Burwinkel, Barbara Yesilyurt, Betul T Neven, Patrick Paridaens, Robert Wildiers, Hans Brenner, Hermann Muller, Heiko Arndt, Volker Stegmaier, Christa Meindl, Alfons Schott, Sarah Bartram, Claus R Schmutzler, Rita K Cox, Angela Brock, Ian W Elliott, Graeme Cross, Simon S Fasching, Peter A Schulz-Wendtland, Ruediger Ekici, Arif B Beckmann, Matthias W Fletcher, Olivia Johnson, Nichola Silva, Isabel Dos Santos Peto, Julian Nevanlinna, Heli Muranen, Taru A Aittomaki, Kristiina Blomqvist, Carl Dork, Thilo Schurmann, Peter Bremer, Michael Hillemanns, Peter Bogdanova, Natalia V Antonenkova, Natalia N Rogov, Yuri I Karstens, Johann H Khusnutdinova, Elza Bermisheva, Marina Prokofieva, Darya Gancev, Shamil Jakubowska, Anna Lubinski, Jan Jaworska, Katarzyna Durda, Katarzyna Nordestgaard, Borge G Bojesen, Stig E Lanng, Charlotte Mannermaa, Arto Kataja, Vesa Kosma, Veli-Matti Hartikainen, Jaana M Radice, Paolo Peterlongo, Paolo Manoukian, Siranoush Bernard, Loris Couch, Fergus J Olson, Janet E Wang, Xianshu Fredericksen, Zachary Alnaes, Grethe Grenaker Kristensen, Vessela Borresen-Dale, Anne-Lise Devilee, Peter Tollenaar, Robert A E M Seynaeve, Caroline M Hooning, Maartje J Garcia-Closas, Montserrat Chanock, Stephen J Lissowska, Jolanta Sherman, Mark E Hall, Per Liu, Jianjun Czene, Kamila Kang, Daehee Yoo, Keun-Young Noh, Dong-Young Lindblom, Annika Margolin, Sara Dunning, Alison M Pharoah, Paul D P Easton, Douglas F Guenel, Pascal Brauch, Hiltrud C1287/A10118/Cancer Research UK/United Kingdom C1287/A12014/Cancer Research UK/United Kingdom CA116201/CA/NCI NIH HHS/United States CA122340/CA/NCI NIH HHS/United States CA128978/CA/NCI NIH HHS/United States CA58860/CA/NCI NIH HHS/United States CA92044/CA/NCI NIH HHS/United States R01 CA122340-01A1/CA/NCI NIH HHS/United States R01 CA122340-02/CA/NCI NIH HHS/United States R01 CA122340-03/CA/NCI NIH HHS/United States R01 CA122340-03S1/CA/NCI NIH HHS/United States R01 CA122340-04/CA/NCI NIH HHS/United States R01 CA122340-05/CA/NCI NIH HHS/United States R01 CA128978-01A2/CA/NCI NIH HHS/United States R01 CA128978-02/CA/NCI NIH HHS/United States R01 CA128978-03/CA/NCI NIH HHS/United States R01 CA128978-04/CA/NCI NIH HHS/United States R01 CA128978-05/CA/NCI NIH HHS/United States U01 CA 69638/CA/NCI NIH HHS/United States U01 CA069417-10/CA/NCI NIH HHS/United States U01 CA069417-11/CA/NCI NIH HHS/United States U01 CA069417-11S1/CA/NCI NIH HHS/United States U01 CA069417-12/CA/NCI NIH HHS/United States U01 CA069417-13/CA/NCI NIH HHS/United States U01 CA069417-14/CA/NCI NIH HHS/United States U01 CA069417-15/CA/NCI NIH HHS/United States U01 CA069417-15S1/CA/NCI NIH HHS/United States U01 CA069417-16/CA/NCI NIH HHS/United States U01 CA69417/CA/NCI NIH HHS/United States U01 CA69467/CA/NCI NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. United States Human mutation Nihms364885 Hum Mutat. 2012 Jul;33(7):1123-32. doi: 10.1002/humu.22089. Epub 2012 Apr 30.

PY - 2012

Y1 - 2012

N2 - A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P

AB - A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P

KW - Breast Neoplasms/ genetics

KW - Chromosomes, Human, Pair 11/ genetics

KW - European Continental Ancestry Group

KW - Female

KW - Genetic Predisposition to Disease/genetics

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Polymorphism, Single Nucleotide/genetics

KW - Receptors, Estrogen/ genetics

KW - Receptors, Progesterone/ genetics

KW - Risk Factors

U2 - 10.1002/humu.22089

DO - 10.1002/humu.22089

M3 - Article

SN - 1098-1004

VL - 33

SP - 1123

EP - 1132

JO - Hum Mutat

JF - Hum Mutat

IS - 7

ER -

11q13 is a susceptibility locus for hormone receptor positive breast cancer

Abstract

Keywords

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