17 salts of ephedrine: Crystal structures and packing analysis

Edwin A. Collier; Roger J. Davey; Simon N. Black; Ron J. Roberts

doi:10.1107/S0108768106012018

17 salts of ephedrine: Crystal structures and packing analysis

Edwin A. Collier, Roger J. Davey, Simon N. Black, Ron J. Roberts

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Abstract

The structures of two neutral and 17 salt forms of the base (1R, 2S)-(-)-ephedrine are reported. These structures are discussed in the light of the conformers of the ephedrine moiety, the existence of bilayers and the structure determining role of the counterions. Overall, most of the salt structures are essentially derived from the observed packing of the neutral base and are dominated by the amphiphilic nature of the ephedrine molecular structure. In a few cases the size and hydrophobicity of the counterion disrupts this behaviour. © 2006 International Union of Crystallography. Printed in Great Britain - all rights reserved.

Original language	English
Pages (from-to)	498-505
Number of pages	7
Journal	Acta Crystallographica Section B: Structural Science
Volume	62
Issue number	3
DOIs	https://doi.org/10.1107/S0108768106012018
Publication status	Published - Jun 2006

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title = "17 salts of ephedrine: Crystal structures and packing analysis",

abstract = "The structures of two neutral and 17 salt forms of the base (1R, 2S)-(-)-ephedrine are reported. These structures are discussed in the light of the conformers of the ephedrine moiety, the existence of bilayers and the structure determining role of the counterions. Overall, most of the salt structures are essentially derived from the observed packing of the neutral base and are dominated by the amphiphilic nature of the ephedrine molecular structure. In a few cases the size and hydrophobicity of the counterion disrupts this behaviour. {\textcopyright} 2006 International Union of Crystallography. Printed in Great Britain - all rights reserved.",

author = "Collier, {Edwin A.} and Davey, {Roger J.} and Black, {Simon N.} and Roberts, {Ron J.}",

year = "2006",

month = jun,

doi = "10.1107/S0108768106012018",

language = "English",

volume = "62",

pages = "498--505",

journal = "Acta Crystallographica Section B: Structural Science",

issn = "0108-7681",

publisher = "International Union of Crystallography",

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T1 - 17 salts of ephedrine: Crystal structures and packing analysis

AU - Collier, Edwin A.

AU - Davey, Roger J.

AU - Black, Simon N.

AU - Roberts, Ron J.

PY - 2006/6

Y1 - 2006/6

N2 - The structures of two neutral and 17 salt forms of the base (1R, 2S)-(-)-ephedrine are reported. These structures are discussed in the light of the conformers of the ephedrine moiety, the existence of bilayers and the structure determining role of the counterions. Overall, most of the salt structures are essentially derived from the observed packing of the neutral base and are dominated by the amphiphilic nature of the ephedrine molecular structure. In a few cases the size and hydrophobicity of the counterion disrupts this behaviour. © 2006 International Union of Crystallography. Printed in Great Britain - all rights reserved.

AB - The structures of two neutral and 17 salt forms of the base (1R, 2S)-(-)-ephedrine are reported. These structures are discussed in the light of the conformers of the ephedrine moiety, the existence of bilayers and the structure determining role of the counterions. Overall, most of the salt structures are essentially derived from the observed packing of the neutral base and are dominated by the amphiphilic nature of the ephedrine molecular structure. In a few cases the size and hydrophobicity of the counterion disrupts this behaviour. © 2006 International Union of Crystallography. Printed in Great Britain - all rights reserved.

U2 - 10.1107/S0108768106012018

DO - 10.1107/S0108768106012018

M3 - Article

SN - 0108-7681

VL - 62

SP - 498

EP - 505

JO - Acta Crystallographica Section B: Structural Science

JF - Acta Crystallographica Section B: Structural Science

IS - 3

ER -

17 salts of ephedrine: Crystal structures and packing analysis

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