[18F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging

Tanuj Puri; Michelle L. Frost; Gary J. Cook; Glen M. Blake

doi:10.3390/tomography7040071

[18F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging

Tanuj Puri, Michelle L. Frost, Gary J. Cook, Glen M. Blake

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([18F]NaF) to understand bone physiology. Dynamic [18F]NaF PET scans may be useful as an imaging biomarker in early phase clinical trials of novel drugs in development by permitting early detection of treatment-response signals that may help avoid late-stage attrition.

Original language	English
Pages (from-to)	843-854
Number of pages	12
Journal	Tomography
Volume	7
Issue number	4
DOIs	https://doi.org/10.3390/tomography7040071
Publication status	Published - 1 Dec 2021

Keywords

PET
Computed tomography
CT
[18F] sodium fluoride
[18F]NaF
Hawkins model
kinetic modeling
bone metabolism
[ F] sodium fluoride
Clinical significance
Dynamic positron emission tomography
[ F]NaF

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

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10.3390/tomography7040071Licence: CC BY

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title = "[18F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging",

abstract = "This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([18F]NaF) to understand bone physiology. Dynamic [18F]NaF PET scans may be useful as an imaging biomarker in early phase clinical trials of novel drugs in development by permitting early detection of treatment-response signals that may help avoid late-stage attrition.",

keywords = "PET, Computed tomography, CT, [18F] sodium fluoride, [18F]NaF, Hawkins model, kinetic modeling, bone metabolism, [ F] sodium fluoride, Clinical significance, Dynamic positron emission tomography, [ F]NaF",

author = "Tanuj Puri and Frost, {Michelle L.} and Cook, {Gary J.} and Blake, {Glen M.}",

year = "2021",

month = dec,

day = "1",

doi = "10.3390/tomography7040071",

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volume = "7",

pages = "843--854",

journal = "Tomography",

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T1 - [18F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging

AU - Puri, Tanuj

AU - Frost, Michelle L.

AU - Cook, Gary J.

AU - Blake, Glen M.

PY - 2021/12/1

Y1 - 2021/12/1

N2 - This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([18F]NaF) to understand bone physiology. Dynamic [18F]NaF PET scans may be useful as an imaging biomarker in early phase clinical trials of novel drugs in development by permitting early detection of treatment-response signals that may help avoid late-stage attrition.

AB - This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([18F]NaF) to understand bone physiology. Dynamic [18F]NaF PET scans may be useful as an imaging biomarker in early phase clinical trials of novel drugs in development by permitting early detection of treatment-response signals that may help avoid late-stage attrition.

KW - PET

KW - Computed tomography

KW - CT

KW - [18F] sodium fluoride

KW - [18F]NaF

KW - Hawkins model

KW - kinetic modeling

KW - bone metabolism

KW - [ F] sodium fluoride

KW - Clinical significance

KW - Dynamic positron emission tomography

KW - [ F]NaF

U2 - 10.3390/tomography7040071

DO - 10.3390/tomography7040071

M3 - Article

C2 - 34941643

VL - 7

SP - 843

EP - 854

JO - Tomography

JF - Tomography

IS - 4

ER -

[18F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging

Abstract

Keywords

Research Beacons, Institutes and Platforms

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