2,4-Diaminothieno[3,2 d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm

Frederick Partridge, Ruth Forman, Nicky J. Willis, Carole J. R. Bataille, Emma Murphy, Anwen E. Brown, Narinder Heyer-Chauhan, Bruno Marinič, Daniel J. C. Sowood, Graham Wynne, Kathryn Else, Angela J. Russell, David B. Sattelle

Research output: Contribution to journalArticlepeer-review


The human whipworm Trichuris trichiura is a parasite that infects around 500 million people globally, with consequences including damage to physical growth and educational performance. Current drugs such as mebendazole have a notable lack of efficacy against whipworm, compared to other soil-transmitted helminths. Mass drug administration programs are therefore unlikely to achieve eradication and new treatments for trichuriasis are desperately needed. All current drug control strategies focus on post-infection eradication, targeting the parasite in vivo. Here we propose developing novel anthelmintics which target the egg stage of the parasite in the soil as an adjunct environmental strategy. As evidence in support of such an approach we describe the actions of a new class of anthelmintic compounds, the 2,4-diaminothieno[3,2 d]pyrimidines (DATPs). This compound class has found broad utility in medicinal chemistry, but has not previously been described as having anthelmintic activity. Importantly, these compounds show efficacy against not only the adult parasite, but also both the embryonated and unembryonated egg stages and thereby may enable a break in the parasite lifecycle.
Original languageEnglish
Article numbere0006487
JournalPLOS Neglected Tropical Diseases
Issue number7
Early online date11 Jul 2018
Publication statusPublished - 11 Jul 2018


  • Animals
  • Anthelmintics/administration & dosage
  • Female
  • Humans
  • Male
  • Mice
  • Ovum/drug effects
  • Parasite Egg Count
  • Pyrimidines/administration & dosage
  • Trichuriasis/drug therapy
  • Trichuris/drug effects


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