2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG

Alison Mcgonagle (Inventor), Allan Jordan, (Inventor), Bohdan Waszkowycz, (Inventor), Colin Hutton, (Inventor), Ian Waddell, (Inventor), James Hitchin (Inventor), Kate Smith (Inventor), Niall Hamilton (Inventor)

Research output: Patent

Abstract

The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.

Original languageEnglish
Patent numberWO2016092326
IPCC07D 413/ 14 A I
Priority date12/12/14
Publication statusPublished - 16 Jun 2016

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre

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