[2]Rotaxane Formation by Transition State Stabilization

Guillaume De Bo, Guillaume Dolphijn, Charlie Mcternan, David Leigh

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    We report on the synthesis of [2]rotaxanes driven by stabilization of the axle-forming transition state. A bifunctional macrocycle, with hydrogen bond donors at one end and acceptors at the other, is used to stabilize the charges that develop during the addition of a primary amine to a cyclic sulfate.
    Original languageEnglish
    JournalJournal of the American Chemical Society
    Early online date16 Jun 2017
    Publication statusPublished - 2017


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