3D bioprinting of photocrosslinkable hydrogel constructs

Ruben Pereira, Paulo Jorge Da Silva Bartolo

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Three-dimensional (3D) bioprinting comprises a group of biofabrication technologies for the additive manufacturing of
    3D constructs by precisely printing biocompatible materials, cells and biochemicals in predesigned spatial positions. These technolo- gies have been successfully applied to fabricate biodegradable 3D constructs with intricate architectures and heterogeneous composi- tion, assuming a pivotal role in the field of tissue engineering. However, the full implementation of bioprinting strongly depends on the development of novel biomaterials exhibiting fast crosslinking schemes and appropriate printability, cell-compatibility and biome- chanical properties. Photocrosslinkable hydrogels are attractive materials for bioprinting as they provide fast polymerization under cell-compatible conditions and exceptional spatiotemporal control over the gelation process. Photopolymerization can also be per- formed during the bioprinting to promote the instantaneous formation of hydrogel with high well-defined architecture and structural stability. In this review paper, we summarize the most recent developments on bioprinting of photocrosslinkable biodegradable hydro- gels for tissue engineering, focusing on the chemical modification strategies and the combination of photocrosslinking reactions with other gelation modalities.
    Original languageEnglish
    Pages (from-to)1-15
    Number of pages15
    JournalJournal of Applied Polymer Science
    Volume132
    Issue number48
    DOIs
    Publication statusPublished - 2015

    Keywords

    • biodegradable;
    • biomaterials;
    • manufacturing;
    • photopolymerization

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