TY - GEN
T1 - 3D reconstruction of both shape and bone mineral density distribution of the femur from DXA images
AU - Humbert, Ludovic
AU - Whitmarsh, Tristan
AU - De Craene, Mathieu
AU - Del Río Barquero, Luis Miguel
AU - Fritscher, Karl
AU - Schubert, Rainer
AU - Eckstein, Felix
AU - Link, Thomas
AU - Frangi, Alejandro F.
PY - 2010
Y1 - 2010
N2 - The diagnosis of osteoporosis and the prevention of femur fractures is a major challenge for our society. However, the diagnosis performed in clinical routine from Dual Energy X-ray Absorptiometry (DXA) images is limited. This paper proposes a 3D reconstruction method of both the shape and the Bone Mineral Density (BMD) distribution of the proximal femur from routinely used DXA images. The reconstruction accuracy that can be obtained from single-view and multi-view DXA devices was assessed. This evaluation, from 20 bone specimens and simulated DXA images, highlighted a mean shape accuracy of 1.3mm and a BMD accuracy of 4.4% from a single-view DXA image. A multi-view configuration with 2 views (frontal-sagittal) appeared as a good compromise (mean shape accuracy of 0.9mm and BMD accuracy of 3.2%). We are currently using this method for in vivo clinical studies in order to improve the diagnosis of osteoporosis and the prevention of femur fractures.
AB - The diagnosis of osteoporosis and the prevention of femur fractures is a major challenge for our society. However, the diagnosis performed in clinical routine from Dual Energy X-ray Absorptiometry (DXA) images is limited. This paper proposes a 3D reconstruction method of both the shape and the Bone Mineral Density (BMD) distribution of the proximal femur from routinely used DXA images. The reconstruction accuracy that can be obtained from single-view and multi-view DXA devices was assessed. This evaluation, from 20 bone specimens and simulated DXA images, highlighted a mean shape accuracy of 1.3mm and a BMD accuracy of 4.4% from a single-view DXA image. A multi-view configuration with 2 views (frontal-sagittal) appeared as a good compromise (mean shape accuracy of 0.9mm and BMD accuracy of 3.2%). We are currently using this method for in vivo clinical studies in order to improve the diagnosis of osteoporosis and the prevention of femur fractures.
KW - 3D reconstruction
KW - Bone mineral density
KW - Dual Energy X-Rays Absorptiometry
KW - Osteoporosis
KW - Statistical atlas
UR - http://www.scopus.com/inward/record.url?scp=77955190437&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2010.5490310
DO - 10.1109/ISBI.2010.5490310
M3 - Conference contribution
AN - SCOPUS:77955190437
SN - 9781424441266
T3 - 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings
SP - 456
EP - 459
BT - 2010 7th IEEE International Symposium on Biomedical Imaging
T2 - 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010
Y2 - 14 April 2010 through 17 April 2010
ER -