5-123I-A-85380 binding to the α4β2-nicotinic receptor in mild cognitive impairment

Emma Terrière, Mary F. Dempsey, Lucie L. Herrmann, Kevin M. Tierney, Jane A. Lonie, Ronan E. O'Carroll, Sally Pimlott, David J. Wyper, Karl Herholz, Klaus P. Ebmeier

    Research output: Contribution to journalArticlepeer-review


    Treatments currently licensed for Alzheimer's dementia target cholinergic brain systems. In vivo nicotinic receptor binding may provide an early marker of illness and treatment suitability. In this pilot, we examined nine patients with amnestic mild cognitive impairment (MCI) and 10 age and education matched healthy volunteers with high resolution SPECT and the nicotinic receptor ligand 5-123I-A-85380. Uptake data were analysed using voxel-based techniques for group comparisons and regression analyses with cognitive impairment as covariates. MCI patients had discrete reductions in uptake in medial temporal cortex. Correlations with cognitive impairment were found in left temporo-parietal areas (Addenbrooke's Cognitive Examination) and bilateral temporo-limbic areas (Rey Auditory Verbal Learning Test), and right parahippocampal gyrus (Rey Complex Figure Test) within the patient group. In vivo nicotinic receptor binding appears to be sensitive to brain changes in MCI. Larger scale explorations of patients undergoing treatment will be necessary to evaluate its use in predicting or monitoring treatment response. © 2008 Elsevier Inc.
    Original languageEnglish
    Pages (from-to)1885-1893
    Number of pages8
    JournalNeurobiology of Aging
    Issue number11
    Publication statusPublished - Nov 2010


    • Alzheimer's disease
    • Amnestic
    • Dementia
    • Mild cognitive impairment
    • Nicotinic acetylcholine receptors
    • Single photon emission tomography


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