8-37h-CGRP antagonizes actions of amylin on carbohydrate metabolism in vitro and in vivo

Ming Wei Wang; Andrew A. Young; T. J. Rink; Garth Cooper

doi:10.1016/0014-5793(91)81282-D

8-37h-CGRP antagonizes actions of amylin on carbohydrate metabolism in vitro and in vivo

Ming Wei Wang, Andrew A. Young, T. J. Rink, Garth Cooper

Division of Cardiovascular Sciences (L5)

Amylin Pharmaceuticals

Research output: Contribution to journal › Article › peer-review

Abstract

8-37hCGRP is a potent antagonist at calcitonin gene-related peptide (CGRP) liver membrane receptors; it also blocks vasodilator actions of CGRP and the related peptide, amylin, in intact rats. We now report that 8-37hCGRP antagonizes amylin inhibition of insulin-stimulated labelled glucose uptake into isolated rat soleus muscle, and inhibits amylin-evoked elevation of plasma lactate and glucose in fasted anaesthetized rats. The different relative potencies of the 3 ligands (amylin, CGRP, 8-37hCGRP) on the liver receptor and on the soleus muscle point to distinct CGRP receptors in liver membranes and amylin receptors on muscle cells. © 1991.

Original language	English
Pages (from-to)	195-198
Number of pages	3
Journal	FEBS Letters
Volume	291
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(91)81282-D
Publication status	Published - 21 Oct 1991

Keywords

Amylin
Calcitonin gene-related peptide
Glucose
Lactate
Plasma calcium
Rat soleus muscle

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10.1016/0014-5793(91)81282-D

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title = "8-37h-CGRP antagonizes actions of amylin on carbohydrate metabolism in vitro and in vivo",

abstract = "8-37hCGRP is a potent antagonist at calcitonin gene-related peptide (CGRP) liver membrane receptors; it also blocks vasodilator actions of CGRP and the related peptide, amylin, in intact rats. We now report that 8-37hCGRP antagonizes amylin inhibition of insulin-stimulated labelled glucose uptake into isolated rat soleus muscle, and inhibits amylin-evoked elevation of plasma lactate and glucose in fasted anaesthetized rats. The different relative potencies of the 3 ligands (amylin, CGRP, 8-37hCGRP) on the liver receptor and on the soleus muscle point to distinct CGRP receptors in liver membranes and amylin receptors on muscle cells. {\textcopyright} 1991.",

keywords = "Amylin, Calcitonin gene-related peptide, Glucose, Lactate, Plasma calcium, Rat soleus muscle",

author = "Wang, {Ming Wei} and Young, {Andrew A.} and Rink, {T. J.} and Garth Cooper",

year = "1991",

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doi = "10.1016/0014-5793(91)81282-D",

language = "English",

volume = "291",

pages = "195--198",

journal = "FEBS Letters",

publisher = "John Wiley & Sons Ltd",

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TY - JOUR

T1 - 8-37h-CGRP antagonizes actions of amylin on carbohydrate metabolism in vitro and in vivo

AU - Wang, Ming Wei

AU - Young, Andrew A.

AU - Rink, T. J.

AU - Cooper, Garth

PY - 1991/10/21

Y1 - 1991/10/21

N2 - 8-37hCGRP is a potent antagonist at calcitonin gene-related peptide (CGRP) liver membrane receptors; it also blocks vasodilator actions of CGRP and the related peptide, amylin, in intact rats. We now report that 8-37hCGRP antagonizes amylin inhibition of insulin-stimulated labelled glucose uptake into isolated rat soleus muscle, and inhibits amylin-evoked elevation of plasma lactate and glucose in fasted anaesthetized rats. The different relative potencies of the 3 ligands (amylin, CGRP, 8-37hCGRP) on the liver receptor and on the soleus muscle point to distinct CGRP receptors in liver membranes and amylin receptors on muscle cells. © 1991.

AB - 8-37hCGRP is a potent antagonist at calcitonin gene-related peptide (CGRP) liver membrane receptors; it also blocks vasodilator actions of CGRP and the related peptide, amylin, in intact rats. We now report that 8-37hCGRP antagonizes amylin inhibition of insulin-stimulated labelled glucose uptake into isolated rat soleus muscle, and inhibits amylin-evoked elevation of plasma lactate and glucose in fasted anaesthetized rats. The different relative potencies of the 3 ligands (amylin, CGRP, 8-37hCGRP) on the liver receptor and on the soleus muscle point to distinct CGRP receptors in liver membranes and amylin receptors on muscle cells. © 1991.

KW - Amylin

KW - Calcitonin gene-related peptide

KW - Glucose

KW - Lactate

KW - Plasma calcium

KW - Rat soleus muscle

U2 - 10.1016/0014-5793(91)81282-D

DO - 10.1016/0014-5793(91)81282-D

M3 - Article

C2 - 1936264

VL - 291

SP - 195

EP - 198

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

8-37h-CGRP antagonizes actions of amylin on carbohydrate metabolism in vitro and in vivo

Abstract

Keywords

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