8;20 Chromosomal translocation in a case of acute leukemia: Cytogenetic, immunophenotypic, ultrastructural, and molecular characteristics

K. F. Jorgenson; G. R. Antoun; C. C. Childs; E. A. Felix; A. Cork; G. Yee; J. M. Trujillo; D. P. Pinkel; T. F. Zipf

8;20 Chromosomal translocation in a case of acute leukemia: Cytogenetic, immunophenotypic, ultrastructural, and molecular characteristics

K. F. Jorgenson, G. R. Antoun, C. C. Childs, E. A. Felix, A. Cork, G. Yee, J. M. Trujillo, D. P. Pinkel, T. F. Zipf

Research output: Contribution to journal › Article › peer-review

Abstract

An 8;20 chromosomal translocation was observed in the leukemia cells of a 3-year-old girl. To our knowledge, this is the first report of this translocation in de novo acute leukemia. This chromosomal defect was present in the leukemia cells at diagnosis and also at relapse, but remission bone marrow cells had the 46,XX karyotype. By morphologic and cytochemical criteria the leukemia was myeloid but these features were more lymphoid when the leukemia recurred. However, the immunophenotype was consistent with myeloid leukemia and did not change at relapse. No evidence for either immunoglobulin or TCR gene rearrangement was observed.

Original language	English
Pages (from-to)	1-9
Number of pages	8
Journal	Cancer Genetics and Cytogenetics
Volume	52
Issue number	1
Publication status	Published - 1991

Keywords

Child, Preschool
Chromosomes, Human, Pair 20
Chromosomes, Human, Pair 8
Female
Genetic Markers
Humans
Immunophenotyping
Karyotyping
genetics: Leukemia, Myeloid, Acute
genetics: Translocation, Genetic
Tumor Markers, Biological

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "8;20 Chromosomal translocation in a case of acute leukemia: Cytogenetic, immunophenotypic, ultrastructural, and molecular characteristics",

abstract = "An 8;20 chromosomal translocation was observed in the leukemia cells of a 3-year-old girl. To our knowledge, this is the first report of this translocation in de novo acute leukemia. This chromosomal defect was present in the leukemia cells at diagnosis and also at relapse, but remission bone marrow cells had the 46,XX karyotype. By morphologic and cytochemical criteria the leukemia was myeloid but these features were more lymphoid when the leukemia recurred. However, the immunophenotype was consistent with myeloid leukemia and did not change at relapse. No evidence for either immunoglobulin or TCR gene rearrangement was observed.",

keywords = "Child, Preschool, Chromosomes, Human, Pair 20, Chromosomes, Human, Pair 8, Female, Genetic Markers, Humans, Immunophenotyping, Karyotyping, genetics: Leukemia, Myeloid, Acute, genetics: Translocation, Genetic, Tumor Markers, Biological",

author = "Jorgenson, {K. F.} and Antoun, {G. R.} and Childs, {C. C.} and Felix, {E. A.} and A. Cork and G. Yee and Trujillo, {J. M.} and Pinkel, {D. P.} and Zipf, {T. F.}",

year = "1991",

language = "English",

volume = "52",

pages = "1--9",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

publisher = "Elsevier BV",

number = "1",

}

TY - JOUR

T1 - 8;20 Chromosomal translocation in a case of acute leukemia: Cytogenetic, immunophenotypic, ultrastructural, and molecular characteristics

AU - Jorgenson, K. F.

AU - Antoun, G. R.

AU - Childs, C. C.

AU - Felix, E. A.

AU - Cork, A.

AU - Yee, G.

AU - Trujillo, J. M.

AU - Pinkel, D. P.

AU - Zipf, T. F.

PY - 1991

Y1 - 1991

N2 - An 8;20 chromosomal translocation was observed in the leukemia cells of a 3-year-old girl. To our knowledge, this is the first report of this translocation in de novo acute leukemia. This chromosomal defect was present in the leukemia cells at diagnosis and also at relapse, but remission bone marrow cells had the 46,XX karyotype. By morphologic and cytochemical criteria the leukemia was myeloid but these features were more lymphoid when the leukemia recurred. However, the immunophenotype was consistent with myeloid leukemia and did not change at relapse. No evidence for either immunoglobulin or TCR gene rearrangement was observed.

AB - An 8;20 chromosomal translocation was observed in the leukemia cells of a 3-year-old girl. To our knowledge, this is the first report of this translocation in de novo acute leukemia. This chromosomal defect was present in the leukemia cells at diagnosis and also at relapse, but remission bone marrow cells had the 46,XX karyotype. By morphologic and cytochemical criteria the leukemia was myeloid but these features were more lymphoid when the leukemia recurred. However, the immunophenotype was consistent with myeloid leukemia and did not change at relapse. No evidence for either immunoglobulin or TCR gene rearrangement was observed.

KW - Child, Preschool

KW - Chromosomes, Human, Pair 20

KW - Chromosomes, Human, Pair 8

KW - Female

KW - Genetic Markers

KW - Humans

KW - Immunophenotyping

KW - Karyotyping

KW - genetics: Leukemia, Myeloid, Acute

KW - genetics: Translocation, Genetic

KW - Tumor Markers, Biological

M3 - Article

SN - 0165-4608

VL - 52

SP - 1

EP - 9

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 1

ER -

8;20 Chromosomal translocation in a case of acute leukemia: Cytogenetic, immunophenotypic, ultrastructural, and molecular characteristics

Abstract

Keywords

UN SDGs

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